| Goblet cell hyperplasia requires high bicarbonate transport to support mucin release G Gorrieri, P Scudieri, E Caci, M Schiavon, V Tomati, F Sirci, F Napolitano, ... Scientific reports 6 (1), 36016, 2016 | 97 | 2016 |
| Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis D Carrella, F Napolitano, R Rispoli, M Miglietta, A Carissimo, L Cutillo, ... Bioinformatics 30 (12), 1787-1788, 2014 | 89 | 2014 |
| Virtual Fragment Screening: Discovery of Histamine H3 Receptor Ligands Using Ligand-Based and Protein-Based Molecular Fingerprints F Sirci, EP Istyastono, HF Vischer, AJ Kooistra, S Nijmeijer, M Kuijer, ... Journal of chemical information and modeling 52 (12), 3308-3324, 2012 | 89 | 2012 |
| Drug-set enrichment analysis: a novel tool to investigate drug mode of action F Napolitano, F Sirci, D Carrella, D di Bernardo Bioinformatics 32 (2), 235-241, 2016 | 83 | 2016 |
| gene2drug: a computational tool for pathway-based rational drug repositioning F Napolitano, D Carrella, B Mandriani, S Pisonero-Vaquero, F Sirci, ... Bioinformatics 34 (9), 1498-1505, 2018 | 78 | 2018 |
| Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists M Wijtmans, D Maussang, F Sirci, DJ Scholten, M Canals, A Mujić-Delić, ... European journal of medicinal chemistry 51, 184-192, 2012 | 73 | 2012 |
| Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists F Sirci, L Goracci, D Rodríguez, J van Muijlwijk-Koezen, ... Journal of computer-aided molecular design 26, 1247-1266, 2012 | 61 | 2012 |
| Detailed analysis of biased histamine H4 receptor signalling by JNJ 7777120 analogues S Nijmeijer, HF Vischer, F Sirci, S Schultes, H Engelhardt, C De Graaf, ... British journal of pharmacology 170 (1), 78-88, 2013 | 51 | 2013 |
| Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds D Carrella, I Manni, B Tumaini, R Dattilo, F Papaccio, M Mutarelli, F Sirci, ... Oncotarget 7 (37), 58743, 2016 | 39 | 2016 |
| Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses F Sirci, F Napolitano, S Pisonero-Vaquero, D Carrella, DL Medina, ... NPJ systems biology and applications 3 (1), 23, 2017 | 26 | 2017 |
| Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel E Pesce, G Gorrieri, F Sirci, F Napolitano, D Carrella, E Caci, V Tomati, ... Journal of Cystic Fibrosis 15 (4), 425-435, 2016 | 20 | 2016 |
| Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B M Concilli, R Petruzzelli, S Parisi, F Catalano, F Sirci, F Napolitano, ... Proceedings of the National Academy of Sciences 117 (51), 32453-32463, 2020 | 15 | 2020 |
| Computational Drug Networks: a computational approach to elucidate drug mode of action and to facilitate drug repositioning for neurodegenerative diseases F Sirci, F Napolitano, D di Bernardo Drug Discovery Today: Disease Models 19, 11-17, 2016 | 9 | 2016 |
| Translating precision medicine for autism spectrum disorder: A pressing need L Pérez-Cano, SA Chenlo, R Sabido-Vera, F Sirci, L Durham, E Guney Drug discovery today 28 (3), 103486, 2023 | 8 | 2023 |
| Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects P Ioan, A Ciogli, F Sirci, R Budriesi, B Cosimelli, M Pierini, E Severi, ... Organic & Biomolecular Chemistry 10 (45), 8994-9003, 2012 | 8 | 2012 |
| Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDAapproved compounds. Oncotarget. 2016. http s D Carrella, I Manni, B Tumaini, R Dattilo, F Papaccio, M Mutarelli, F Sirci, ... doi. org/10.18632/oncot arget 11318, 0 | 5 | |
| Characterization of a clinically and biologically defined subgroup of patients with autism spectrum disorder and identification of a tailored combination treatment L Pérez-Cano, L Boccuto, F Sirci, JM Hidalgo, S Valentini, M Bosio, ... Biomedicines 12 (5), 991, 2024 | 2 | 2024 |
| DEPI v3: A systems biology and artificial intelligence based patient stratification and drug positioning platform for neurodevelopmental disorders L PÉREZ CANO, F Sirci, I Ariz-Extreme, D Boloc, S Azidane Chenlo, ... RExPO22, 2022 | 1 | 2022 |
| Optimizing virtual fragment screening for GPCRs: identification of novel ligands for the histamine H3 receptor using ligand-based and structure-based molecular fingerprints F Sirci, EP Istyastono, HF Vischer, AJ Kooistra, S Nijmeijer, M Kuijer, ... J Med Chem, 2012 | 1 | 2012 |
| DrugRepoChatter: a drug repurposing expert chatbot curated by the REPO4EU consortium FM Delgado-Chaves, L Spindler, F Firoozbakht, A Maier, M Hartung, ... Drug Repurposing 1 (2), 20240014, 2024 | | 2024 |
