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Alexander J. Whitworth
Alexander J. Whitworth
在 mrc-mbu.cam.ac.uk 的电子邮件经过验证 - 首页
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
13570*2021
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
JC Greene, AJ Whitworth, I Kuo, LA Andrews, MB Feany, LJ Pallanck
Proceedings of the National Academy of Sciences 100 (7), 4078-4083, 2003
14022003
The PINK1/Parkin pathway regulates mitochondrial morphology
AC Poole, RE Thomas, LA Andrews, HM McBride, AJ Whitworth, ...
Proceedings of the National Academy of Sciences 105 (5), 1638-1643, 2008
10162008
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
E Ziviani, RN Tao, AJ Whitworth
Proceedings of the National Academy of Sciences 107 (11), 5018-5023, 2010
8192010
PINK1 cleavage at position A103 by the mitochondrial protease PARL
E Deas, H Plun-Favreau, S Gandhi, H Desmond, S Kjaer, SHY Loh, ...
Human molecular genetics 20 (5), 867-879, 2011
5322011
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
AJ Whitworth, DA Theodore, JC Greene, H Beneš, PD Wes, LJ Pallanck
Proceedings of the National Academy of Sciences 102 (22), 8024-8029, 2005
4702005
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
CP Webster, EF Smith, CS Bauer, A Moller, GM Hautbergue, L Ferraiuolo, ...
The EMBO journal 35 (15), 1656-1676, 2016
4382016
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson’s disease
M Meulener, AJ Whitworth, CE Armstrong-Gold, P Rizzu, P Heutink, ...
Current Biology 15 (17), 1572-1577, 2005
4112005
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
VS Burchell, DE Nelson, A Sanchez-Martinez, M Delgado-Camprubi, ...
Nature neuroscience 16 (9), 1257-1265, 2013
3592013
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
LS Tain, H Mortiboys, RN Tao, E Ziviani, O Bandmann, AJ Whitworth
Nature neuroscience 12 (9), 1129-1135, 2009
3542009
The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson’s disease
DC Schöndorf, D Ivanyuk, P Baden, A Sanchez-Martinez, S De Cicco, ...
Cell reports 23 (10), 2976-2988, 2018
3042018
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
VK Godena, N Brookes-Hocking, A Moller, G Shaw, M Oswald, ...
Nature communications 5 (1), 5245, 2014
2932014
Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
JJ Lee, A Sanchez-Martinez, AM Zarate, C Benincá, U Mayor, MJ Clague, ...
Journal of Cell Biology 217 (5), 1613-1622, 2018
2842018
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
JC Greene, AJ Whitworth, LA Andrews, TJ Parker, LJ Pallanck
Human molecular genetics 14 (6), 799-811, 2005
2312005
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin
AJ Whitworth, JR Lee, VMW Ho, R Flick, R Chowdhury, GA McQuibban
Disease models & mechanisms 1 (2-3), 168-174, 2008
2182008
PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo?
AJ Whitworth, LJ Pallanck
Current opinion in genetics & development 44, 47-53, 2017
1642017
Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
A Sanchez-Martinez, M Beavan, ME Gegg, KY Chau, AJ Whitworth, ...
Scientific reports 6 (1), 31380, 2016
1632016
The PINK1/Parkin pathway: a mitochondrial quality control system?
AJ Whitworth, LJ Pallanck
Journal of bioenergetics and biomembranes 41, 499-503, 2009
1522009
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease
AJ Whitworth, PD Wes, LJ Pallanck
Drug discovery today 11 (3-4), 119-126, 2006
1482006
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 16063, 2017
1402017
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