| Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates. JS Sun, JC François, T Montenay-Garestier, T Saison-Behmoaras, V Roig, ... Proceedings of the National Academy of Sciences 86 (23), 9198-9202, 1989 | 283 | 1989 |
| Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate. JC François, T Saison-Behmoaras, C Barbier, M Chassignol, NT Thuong, ... Proceedings of the National Academy of Sciences 86 (24), 9702-9706, 1989 | 262 | 1989 |
| Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides JC Francois, T Saison-Behmoaras, NT Thuong, C Helene Biochemistry 28 (25), 9617-9619, 1989 | 170 | 1989 |
| Temporal Variations in the Dynamics of Potentially Microcystin-Producing Strains in a Bloom-Forming Planktothrix agardhii (Cyanobacterium) Population E Briand, M Gugger, JC François, C Bernard, JF Humbert, C Quiblier Applied and environmental microbiology 74 (12), 3839-3848, 2008 | 167 | 2008 |
| Sequence-specific recognition of the major groove of DNA by oligodeoxynucleotides via triple helix formation. Footprinting studies JC François, T Saison-Behmoaras, C Hélène Nucleic acids research 16 (24), 11431-11440, 1988 | 166 | 1988 |
| Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates. JS Sun, C Giovannangeli, JC Francois, R Kurfurst, T Montenay-Garestier, ... Proceedings of the National Academy of Sciences 88 (14), 6023-6027, 1991 | 137 | 1991 |
| Periodic cleavage of poly (dA) by oligothymidylates covalently linked to the 1, 10-phenanthroline-copper complex JC Francois, T Saison-Behmoaras, M Chassignol, NT Thuong, JS Sun, ... Biochemistry 27 (7), 2272-2276, 1988 | 132 | 1988 |
| Sequence-targeted cleavage of single-and double-stranded DNA by oligothymidylates covalently linked to 1, 10-phenanthroline JC François, T Saison-Behmoaras, M Chassignol, NT Thuong, C Helene Journal of Biological Chemistry 264 (10), 5891-5898, 1989 | 124 | 1989 |
| DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes AA Fokina, DA Stetsenko, JC François Expert opinion on biological therapy 15 (5), 689-711, 2015 | 116 | 2015 |
| Effect of competing self-structure on triplex formation with purine-rich oligodeoxynucleotides containing GA repeats SB Noonberg, JC François, T Garestier, C Héiène Nucleic acids research 23 (11), 1956-1963, 1995 | 100 | 1995 |
| Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR: I. Balneation study K Mezhoud, D Praseuth, S Puiseux-Dao, JC François, C Bernard, ... Aquatic Toxicology 86 (2), 166-175, 2008 | 96 | 2008 |
| Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway N Milosch, G Tanriöver, A Kundu, A Rami, JC Francois, F Baumkötter, ... Cell death & disease 5 (8), e1391-e1391, 2014 | 95 | 2014 |
| Proteomic and phosphoproteomic analysis of cellular responses in medaka fish (Oryzias latipes) following oral gavage with microcystin-LR K Mezhoud, AL Bauchet, S Château-Joubert, D Praseuth, A Marie, ... Toxicon 51 (8), 1431-1439, 2008 | 78 | 2008 |
| Unusual DNA conformations: implications for telomeres M Mills, L Lacroix, PB Arimondo, JL Leroy, JC François, H Klump, ... Current Medicinal Chemistry-Anti-Cancer Agents 2 (5), 627-644, 2002 | 73 | 2002 |
| Sequence-targeted cleavage of nucleic acids by oligo-[. alpha.] thymidylate-phenanthroline conjugates: parallel and antiparallel double helices are formed with DNA and RNA … JS Sun, JC Francois, R Lavery, T Saison-Behmoaras, ... Biochemistry 27 (16), 6039-6045, 1988 | 68 | 1988 |
| The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons C George, G Gontier, P Lacube, JC François, M Holzenberger, S Aïd Brain 140 (7), 2012-2027, 2017 | 67 | 2017 |
| The spherulites™: a promising carrier for oligonucleotide delivery N Mignet, A Brun, C Degert, B Delord, D Roux, C Hélène, R Laversanne, ... Nucleic Acids Research 28 (16), 3134-3142, 2000 | 60 | 2000 |
| Targeting insulin-like growth factor I with 10–23 DNAzymes: 2′-O-methyl modifications in the catalytic core enhance mRNA cleavage AA Fokina, MI Meschaninova, T Durfort, AG Venyaminova, JC François Biochemistry 51 (11), 2181-2191, 2012 | 54 | 2012 |
| A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain Z Hassani, JC Francois, G Alfama, GM Dubois, M Paris, C Giovannangeli, ... Nucleic acids research 35 (9), e65, 2007 | 54 | 2007 |
| Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model T Durfort, M Tkach, MI Meschaninova, MA Rivas, PV Elizalde, ... PLoS One 7 (1), e29213, 2012 | 52 | 2012 |
