Comprehensive genomic profiles of small cell lung cancer J George, JS Lim, SJ Jang, Y Cun, L Ozretić, G Kong, F Leenders, X Lu, ... Nature 524 (7563), 47-53, 2015 | 2086 | 2015 |
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer K Weiskopf, NS Jahchan, PJ Schnorr, S Cristea, AM Ring, RL Maute, ... The Journal of clinical investigation 126 (7), 2610-2620, 2016 | 414 | 2016 |
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer JS Lim, A Ibaseta, MM Fischer, B Cancilla, G O’Young, S Cristea, VC Luca, ... Nature 545 (7654), 360-364, 2017 | 405 | 2017 |
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors NS Jahchan, JT Dudley, PK Mazur, N Flores, D Yang, A Palmerton, ... Cancer discovery 3 (12), 1364-1377, 2013 | 385 | 2013 |
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility SK Denny*, D Yang*, CH Chuang, JJ Brady, JS Lim, BM Grüner, ... Cell, 2016 | 350 | 2016 |
Molecular recording of mammalian embryogenesis MM Chan, ZD Smith, S Grosswendt, H Kretzmer, TM Norman, B Adamson, ... Nature 570 (7759), 77-82, 2019 | 316 | 2019 |
Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing SH Chiou, IP Winters, J Wang, S Naranjo, C Dudgeon, FB Tamburini, ... Genes & development 29 (14), 1576-1585, 2015 | 275 | 2015 |
Mapping transcriptomic vector fields of single cells X Qiu, Y Zhang, JD Martin-Rufino, C Weng, S Hosseinzadeh, D Yang, ... Cell 185 (4), 690-711. e45, 2022 | 233 | 2022 |
Efficient C• G-to-G• C base editors developed using CRISPRi screens, target-library analysis, and machine learning LW Koblan, M Arbab, MW Shen, JA Hussmann, AV Anzalone, JL Doman, ... Nature biotechnology 39 (11), 1414-1425, 2021 | 170 | 2021 |
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution D Yang, MG Jones, S Naranjo, WM Rideout III, KHJ Min, R Ho, W Wu, ... Cell 185 (11), 1905-1923. e25, 2022 | 159 | 2022 |
Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis CH Chuang, PG Greenside, ZN Rogers, JJ Brady, D Yang, RK Ma, ... Nature medicine 23 (3), 291-300, 2017 | 157 | 2017 |
Intertumoral heterogeneity in SCLC is influenced by the cell type of origin D Yang, SK Denny, PG Greenside, AC Chaikovsky, JJ Brady, Y Ouadah, ... Cancer discovery 8 (10), 1316-1331, 2018 | 133 | 2018 |
Mapping the genetic landscape of DNA double-strand break repair JA Hussmann, J Ling, P Ravisankar, J Yan, A Cirincione, A Xu, ... Cell 184 (22), 5653-5669. e25, 2021 | 122 | 2021 |
Identification and targeting of long-term tumor-propagating cells in small cell lung cancer N Jahchan, J Lim, B Bola, D Yang, J George, M Peifer, F Blackhall, C Dive, ... Cancer discovery 11 (2), S12, 2016 | 91 | 2016 |
An in vivo multiplexed small-molecule screening platform BM Grüner*, CJ Schulze*, D Yang, D Ogasawara, MM Dix, ZN Rogers, ... Nature Methods, 2016 | 68 | 2016 |
BLIMP1 induces transient metastatic heterogeneity in pancreatic cancer SH Chiou, VI Risca, GX Wang, D Yang, BM Grüner, AS Kathiria, RK Ma, ... Cancer discovery 7 (10), 1184-1199, 2017 | 62 | 2017 |
Obligate progression precedes lung adenocarcinoma dissemination DR Caswell*, CH Chuang*, D Yang, SH Chiou, S Cheemalavagu, ... Cancer discovery 4 (7), 781-789, 2014 | 56 | 2014 |
Axon-like protrusions promote small cell lung cancer migration and metastasis D Yang, F Qu, H Cai, CH Chuang, JS Lim, N Jahchan, BM Grüner, ... Elife 8, e50616, 2019 | 48 | 2019 |
Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells CH Chuang, D Yang, G Bai, A Freeland, SC Pruitt, JC Schimenti Nucleic acids research 40 (11), 4914-4924, 2012 | 48 | 2012 |
Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability CH Chuang, M Dorsch, P Dujardin, S Silas, K Ueffing, JM Hölken, D Yang, ... Cancer research 81 (3), 567-579, 2021 | 35 | 2021 |