Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq I Tirosh, B Izar, SM Prakadan, MH Wadsworth, D Treacy, JJ Trombetta, ... Science 352 (6282), 189-196, 2016 | 4013 | 2016 |
Scaling by shrinking: empowering single-cell'omics' with microfluidic devices SM Prakadan, AK Shalek, DA Weitz Nature Reviews Genetics 18 (6), 345-361, 2017 | 334 | 2017 |
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction AS Genshaft, S Li, CJ Gallant, S Darmanis, SM Prakadan, CGK Ziegler, ... Genome biology 17, 1-15, 2016 | 167 | 2016 |
IFNγ-dependent tissue-immune homeostasis is co-opted in the tumor microenvironment CJ Nirschl, M Suárez-Fariñas, B Izar, S Prakadan, R Dannenfelser, ... Cell 170 (1), 127-141. e15, 2017 | 152 | 2017 |
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer B Hamza, SR Ng, SM Prakadan, FF Delgado, CR Chin, EM King, LF Yang, ... Proceedings of the National Academy of Sciences 116 (6), 2232-2236, 2019 | 60 | 2019 |
Linking single-cell measurements of mass, growth rate, and gene expression RJ Kimmerling, SM Prakadan, AJ Gupta, NL Calistri, MM Stevens, ... Genome biology 19, 1-13, 2018 | 50 | 2018 |
Mechanisms of lymphoma clearance induced by high-dose alkylating agents C Lossos, Y Liu, KE Kolb, AL Christie, A Van Scoyk, SM Prakadan, ... Cancer discovery 9 (7), 944-961, 2019 | 39 | 2019 |
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases SM Prakadan, CA Alvarez-Breckenridge, SC Markson, AE Kim, RH Klein, ... Nature communications 12 (1), 5955, 2021 | 35 | 2021 |
PI3Kβ controls immune evasion in PTEN-deficient breast tumours JS Bergholz, Q Wang, Q Wang, M Ramseier, S Prakadan, W Wang, ... Nature 617 (7959), 139-146, 2023 | 28 | 2023 |
Phase II study of pembrolizumab in leptomeningeal carcinomatosis. PK Brastianos, S Prakadan, C Alvarez-Breckenridge, EQ Lee, ... Journal of Clinical Oncology 36 (15_suppl), 2007-2007, 2018 | 19 | 2018 |
MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection S Khuzwayo, M Mthembu, EW Meermeier, SM Prakadan, SW Kazer, ... Frontiers in immunology 12, 631410, 2021 | 17 | 2021 |
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival CN Tzouanas, MS Sherman, JES Shay, AJ Rubin, BE Mead, TT Dao, ... Biorxiv, 2023 | 2 | 2023 |
Single-cell methods for profiling tumor & microenvironment responses to therapeutic challenges SM Prakadan Massachusetts Institute of Technology, 2020 | | 2020 |
Linking Biophysical and Transcriptional Profiles of In Vivo-Treated Human Leukemias on a Single-Cell Level Uniquely Resolves Subpopulations of Response MA Murakami, MM Stevens, RJ Kimmerling, AJ Gupta, H Liu, ... Blood 130, 3987, 2017 | | 2017 |