| Dihydroorotate dehydrogenase inhibitors in anti-infective drug research D Boschi, AC Pippione, S Sainas, ML Lolli European journal of medicinal chemistry 183, 111681, 2019 | 77 | 2019 |
| Use of human dihydroorotate dehydrogenase (hDHODH) inhibitors in autoimmune diseases and new perspectives in cancer therapy ML Lolli, S Sainas, AC Pippione, M Giorgis, D Boschi, F Dosio Recent Patents on Anti-Cancer Drug Discovery 13 (1), 86-105, 2018 | 76 | 2018 |
| NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties D Boschi, GC Tron, L Lazzarato, K Chegaev, C Cena, A Di Stilo, M Giorgis, ... Journal of medicinal chemistry 49 (10), 2886-2897, 2006 | 71 | 2006 |
| Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors S Sainas, AC Pippione, E Lupino, M Giorgis, P Circosta, V Gaidano, ... Journal of medicinal chemistry 61 (14), 6034-6055, 2018 | 66 | 2018 |
| Mechanisms of liposomes/water partitioning of (p-methylbenzyl) alkylamines R Fruttero, G Caron, E Fornatto, D Boschi, G Ermondi, A Gasco, ... Pharmaceutical research 15, 1407-1413, 1998 | 64 | 1998 |
| Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds S Sainas, AC Pippione, M Giorgis, E Lupino, P Goyal, C Ramondetti, ... European Journal of Medicinal Chemistry 129, 287-302, 2017 | 63 | 2017 |
| Substituted 4-hydroxy-1, 2, 3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches AC Pippione, F Dosio, A Ducime, A Federico, K Martina, S Sainas, ... MedChemComm 6 (7), 1285-1292, 2015 | 55 | 2015 |
| Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid AC Pippione, IM Carnovale, D Bonanni, M Sini, P Goyal, E Marini, K Pors, ... European Journal of Medicinal Chemistry 150, 930-945, 2018 | 53 | 2018 |
| The Furoxan System as a Useful Tool for Balancing" Hybrids" with Mixed. alpha. 1-Antagonist and NO-like Vasodilator Activities R Fruttero, D Boschi, A Di Stilo, A Gasco Journal of medicinal chemistry 38 (25), 4944-4949, 1995 | 51 | 1995 |
| Synthesis and voltage-clamp studies of methyl 1, 4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl) pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl … S Visentin, P Amiel, R Fruttero, D Boschi, C Roussel, L Giusta, E Carbone, ... Journal of medicinal chemistry 42 (8), 1422-1427, 1999 | 48 | 1999 |
| Studies on agents with mixed NO-dependent vasodilating and β-blocking activities D Boschi, A Di Stilo, C Cena, M Lolli, R Fruttero, A Gasco Pharmaceutical research 14, 1750-1758, 1997 | 42 | 1997 |
| Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach AC Pippione, A Giraudo, D Bonanni, IM Carnovale, E Marini, C Cena, ... European Journal of Medicinal Chemistry 139, 936-946, 2017 | 40 | 2017 |
| Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents K Chegaev, L Lazzarato, Y Tamboli, D Boschi, M Blangetti, A Scozzafava, ... Bioorganic & Medicinal Chemistry 22 (15), 3913-3921, 2014 | 39 | 2014 |
| The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX‐2 Endowed with Anti‐Aggregatory and Vasodilating Activities E Del Grosso, D Boschi, L Lazzarato, C Cena, A Di Stilo, R Fruttero, ... Chemistry & biodiversity 2 (7), 886-900, 2005 | 39 | 2005 |
| Bioisosteres of indomethacin as inhibitors of aldo-keto reductase 1C3 ML Lolli, IM Carnovale, AC Pippione, WY Wahlgren, D Bonanni, E Marini, ... ACS medicinal chemistry letters 10 (4), 437-443, 2019 | 37 | 2019 |
| Use of the furoxan (1, 2, 5-oxadiazole 2-oxide) system in the design of new NO-donor antioxidant hybrids C Cena, M Bertinaria, D Boschi, M Giorgis, A Gasco Arkivoc 7, 301-309, 2006 | 37 | 2006 |
| 4-Hydroxy-1, 2, 3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site A Giraudo, J Krall, B Nielsen, TE Sørensen, KT Kongstad, B Rolando, ... European Journal of Medicinal Chemistry 158, 311-321, 2018 | 35 | 2018 |
| Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants C Cena, D Boschi, GC Tron, K Chegaev, L Lazzarato, A Di Stilo, ... Bioorganic & medicinal chemistry letters 14 (24), 5971-5974, 2004 | 35 | 2004 |
| N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK AC Pippione, S Sainas, A Federico, E Lupino, M Piccinini, M Kubbutat, ... MedChemComm 9 (6), 963-968, 2018 | 33 | 2018 |
| Multitarget drugs: Focus on the NO-donor hybrid drugs A Gasco, D Boschi, K Chegaev, C Cena, A Di Stilo, R Fruttero, ... Pure and applied chemistry 80 (8), 1693-1701, 2008 | 33 | 2008 |
