Patented therapeutic approaches targeting LRP/LR for cancer treatment L Vania, G Morris, TC Otgaar, MJ Bignoux, M Bernert, J Burns, ... Expert opinion on therapeutic patents 29 (12), 987-1009, 2019 | 21 | 2019 |
LRP:: FLAG rescues cells from amyloid-β-mediated cytotoxicity through increased TERT levels and telomerase activity MJ Bignoux, K Cuttler, TC Otgaar, E Ferreira, BT Letsolo, SFT Weiss Journal of Alzheimer's Disease 69 (3), 729-741, 2019 | 12 | 2019 |
LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice E Ferreira, MJ Bignoux, TC Otgaar, N Tagliatti, K Jovanovic, BT Letsolo, ... Oncotarget 9 (43), 27059, 2018 | 11 | 2018 |
LRP:: FLAG reduces phosphorylated tau levels in Alzheimer’s disease cell culture models K Cuttler, MJ Bignoux, TC Otgaar, S Chigumba, E Ferreira, SFT Weiss Journal of Alzheimer's Disease 76 (2), 753-768, 2020 | 5 | 2020 |
LRP:: FLAG reduces phosphorylated tau levels in Alzheimer’s Disease K Cuttler, MJ Bignoux, TC Otgaar, S Chigumba, E Ferreira, SFT Weiss bioRxiv, 2020.01. 14.905661, 2020 | 2 | 2020 |
Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells MJ Bignoux, TC Otgaar, M Bernert, SFT Weiss, E Ferreira FEBS Open bio 13 (2), 323-340, 2023 | 1 | 2023 |
Compounds for use in the treatment of parkinson's disease SFT Weiss, E VAN DER MERWE, K Cuttler, M Bignoux, J Burns US Patent App. 17/298,415, 2022 | 1 | 2022 |
A method of decreasing concentration of tau (t) protein and/or phosphorylated tau (t) protein SFT Weiss, K Cuttler, TC Otgaar, E VAN DER MERWE, MJ Bignoux US Patent App. 17/609,731, 2023 | | 2023 |
Targeting LRP/LR for the prevention of tumour formation and metastasis in lung cancer models M Bignoux Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa, 2022 | | 2022 |
Analysis on the effect of overexpressing LRP on amyloid beta and TERT expression MJ Bignoux, TC Otgaar, BT Letsolo, EFSFT Weiss, MJ Bignoux, ... stress 121 (7), 1046-1053, 2018 | | 2018 |
In vivo and in vitro analysis on the effect of LRP/LR on alzheimer's disease related proteins, TERT expression and telomerase activity in alzheimer's disease models M Bignoux | | 2018 |