| Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration C Lagier-Tourenne, M Baughn, F Rigo, S Sun, P Liu, HR Li, J Jiang, ... Proceedings of the National Academy of Sciences 110 (47), E4530-E4539, 2013 | 669 | 2013 |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ... Nature neuroscience 18 (9), 1226-1229, 2015 | 629 | 2015 |
| Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ... Neuron 90 (3), 535-550, 2016 | 571 | 2016 |
| HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism SM Weyn-Vanhentenryck, A Mele, Q Yan, S Sun, N Farny, Z Zhang, ... Cell reports 6 (6), 1139-1152, 2014 | 364 | 2014 |
| Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2 C Zhang, Z Zhang, J Castle, S Sun, J Johnson, AR Krainer, MQ Zhang Genes & development 22 (18), 2550-2563, 2008 | 339 | 2008 |
| SRSF1-regulated alternative splicing in breast cancer O Anczuków, M Akerman, A Cléry, J Wu, C Shen, NH Shirole, A Raimer, ... Molecular cell 60 (1), 105-117, 2015 | 331 | 2015 |
| ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP S Sun, SC Ling, J Qiu, CP Albuquerque, Y Zhou, S Tokunaga, H Li, H Qiu, ... Nature communications 6 (1), 6171, 2015 | 241 | 2015 |
| A splicing-independent function of SF2/ASF in microRNA processing H Wu, S Sun, K Tu, Y Gao, B Xie, AR Krainer, J Zhu Molecular cell 38 (1), 67-77, 2010 | 236 | 2010 |
| SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control S Sun, Z Zhang, R Sinha, R Karni, AR Krainer Nature structural & molecular biology 17 (3), 306-312, 2010 | 231 | 2010 |
| C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation W Cheng, S Wang, AA Mestre, C Fu, A Makarem, F Xian, LR Hayes, ... Nature communications 9 (1), 51, 2018 | 193 | 2018 |
| Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS S Sun, Y Sun, SC Ling, L Ferraiuolo, M McAlonis-Downes, Y Zou, ... Proceedings of the National Academy of Sciences 112 (50), E6993-E7002, 2015 | 185 | 2015 |
| Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1 A Israelson, D Ditsworth, S Sun, SW Song, J Liang, M Hruska-Plochan, ... Neuron 86 (1), 218-232, 2015 | 125 | 2015 |
| CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ... Neuron 104 (5), 885-898. e8, 2019 | 118 | 2019 |
| SpliceTrap: a method to quantify alternative splicing under single cellular conditions J Wu, M Akerman, S Sun, WR McCombie, AR Krainer, MQ Zhang Bioinformatics 27 (21), 3010-3016, 2011 | 118 | 2011 |
| Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2 S Sun, ZUO Zhang, O Fregoso, AR Krainer Rna 18 (2), 274-283, 2012 | 108 | 2012 |
| PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel J Yang, J Chen, M del Carmen Vitery, J Osei-Owusu, J Chu, H Yu, S Sun, ... Science 364 (6438), 395-399, 2019 | 104 | 2019 |
| Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis SC Ling, SG Dastidar, S Tokunaga, WY Ho, K Lim, H Ilieva, PA Parone, ... elife 8, e40811, 2019 | 74 | 2019 |
| Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis D Ditsworth, M Maldonado, M McAlonis-Downes, S Sun, A Seelman, ... Acta neuropathologica 133, 907-922, 2017 | 69 | 2017 |
| Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD S Wang, MJ Latallo, Z Zhang, B Huang, DG Bobrovnikov, D Dong, ... Nature communications 12 (1), 4908, 2021 | 55 | 2021 |
| UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction BL Zaepfel, Z Zhang, K Maulding, AN Coyne, W Cheng, LR Hayes, ... Cell reports 34 (13), 2021 | 21 | 2021 |
