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Patient-specific and genome-edited induced pluripotent stem cell–derived cardiomyocytes elucidate single-cell phenotype of Brugada syndrome P Liang, K Sallam, H Wu, Y Li, I Itzhaki, P Garg, Y Zhang, V Termglichan, ... Journal of the American College of Cardiology 68 (19), 2086-2096, 2016 | 221 | 2016 |
In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1 and its target slug RK Hopper, JRAJ Moonen, I Diebold, A Cao, CJ Rhodes, NF Tojais, ... Circulation 133 (18), 1783-1794, 2016 | 220 | 2016 |
Patient-specific iPSC-derived endothelial cells uncover pathways that protect against pulmonary hypertension in BMPR2 mutation carriers M Gu, NY Shao, S Sa, D Li, V Termglinchan, M Ameen, I Karakikes, ... Cell stem cell 20 (4), 490-504. e5, 2017 | 202 | 2017 |
Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-adrenergic signaling in an iPSC model of dilated cardiomyopathy H Wu, J Lee, LG Vincent, Q Wang, M Gu, F Lan, JM Churko, KI Sallam, ... Cell stem cell 17 (1), 89-100, 2015 | 194 | 2015 |
Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing Y Wang, P Liang, F Lan, H Wu, L Lisowski, M Gu, S Hu, MA Kay, ... Journal of the American College of Cardiology 64 (5), 451-459, 2014 | 179 | 2014 |
Elafin reverses pulmonary hypertension via caveolin-1–dependent bone morphogenetic protein signaling NP Nickel, E Spiekerkoetter, M Gu, CG Li, H Li, M Kaschwich, I Diebold, ... American journal of respiratory and critical care medicine 191 (11), 1273-1286, 2015 | 144 | 2015 |
Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell–derived endothelial cells improve myocardial function by paracrine activation M Gu, PK Nguyen, AS Lee, D Xu, S Hu, JR Plews, L Han, BC Huber, ... Circulation research 111 (7), 882-893, 2012 | 128 | 2012 |
Generation of quiescent cardiac fibroblasts from human induced pluripotent stem cells for in vitro modeling of cardiac fibrosis H Zhang, L Tian, M Shen, C Tu, H Wu, M Gu, DT Paik, JC Wu Circulation research 125 (5), 552-566, 2019 | 127 | 2019 |
Intrinsic endocardial defects contribute to hypoplastic left heart syndrome Y Miao, L Tian, M Martin, SL Paige, FX Galdos, J Li, A Klein, H Zhang, ... Cell stem cell 27 (4), 574-589. e8, 2020 | 120 | 2020 |
Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells X Sun, Y Fu, M Gu, L Zhang, D Li, H Li, S Chien, JYJ Shyy, Y Zhu Proceedings of the National Academy of Sciences 113 (3), 769-774, 2016 | 109 | 2016 |
Induced pluripotent stem cell model of pulmonary arterial hypertension reveals novel gene expression and patient specificity S Sa, M Gu, J Chappell, NY Shao, M Ameen, KAT Elliott, D Li, F Grubert, ... American journal of respiratory and critical care medicine 195 (7), 930-941, 2017 | 88 | 2017 |
RNA sequencing analysis detection of a novel pathway of endothelial dysfunction in pulmonary arterial hypertension CJ Rhodes, H Im, A Cao, JK Hennigs, L Wang, S Sa, PI Chen, NP Nickel, ... American journal of respiratory and critical care medicine 192 (3), 356-366, 2015 | 88 | 2015 |
Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension A Reyes-Palomares, M Gu, F Grubert, I Berest, S Sa, M Kasowski, ... Nature communications 11 (1), 1673, 2020 | 64 | 2020 |
BMP10 signaling promotes the development of endocardial cells from human pluripotent stem cell-derived cardiovascular progenitors AA Mikryukov, A Mazine, B Wei, D Yang, Y Miao, M Gu, GM Keller Cell Stem Cell 28 (1), 96-111. e7, 2021 | 62 | 2021 |
A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain Y Fu, Y Hou, C Fu, M Gu, C Li, W Kong, X Wang, JYJ Shyy, Y Zhu Circulation research 108 (4), 410-417, 2011 | 58 | 2011 |
Upregulation of human endogenous retrovirus-K is linked to immunity and inflammation in pulmonary arterial hypertension T Saito, K Miyagawa, SY Chen, R Tamosiuniene, L Wang, O Sharpe, ... Circulation 136 (20), 1920-1935, 2017 | 57 | 2017 |
Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism M Gu, NM Mordwinkin, NG Kooreman, J Lee, H Wu, S Hu, JM Churko, ... European heart journal 36 (13), 806-816, 2015 | 51 | 2015 |
Efficient differentiation of human pluripotent stem cells to endothelial cells M Gu Current protocols in human genetics 98 (1), e64, 2018 | 50 | 2018 |
Micro RNA‐483 amelioration of experimental pulmonary hypertension J Zhang, Y He, X Yan, S Chen, M He, Y Lei, J Zhang, B Gongol, M Gu, ... EMBO Molecular Medicine 12 (5), e11303, 2020 | 48 | 2020 |