| Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ... Nature 481 (7381), 380-384, 2012 | 1932 | 2012 |
| The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α L Zhong, A D'Urso, D Toiber, C Sebastian, RE Henry, DD Vadysirisack, ... Cell 140 (2), 280-293, 2010 | 1128 | 2010 |
| Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. O Iliopoulos, AP Levy, C Jiang, WG Kaelin Jr, MA Goldberg Proceedings of the National Academy of Sciences 93 (20), 10595-10599, 1996 | 1073 | 1996 |
| Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase T Kamura, DM Koepp, MN Conrad, D Skowyra, RJ Moreland, O Iliopoulos, ... Science 284 (5414), 657-661, 1999 | 967 | 1999 |
| Tumour suppression by the human von Hippel-Lindau gene product O Iliopoulos, A Kibel, S Gray, WG Kaelin Jr Nature medicine 1 (8), 822-826, 1995 | 880 | 1995 |
| Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C A Kibel, O Iliopoulos, JA DeCaprio, WG Kaelin Jr Science 269 (5229), 1444-1446, 1995 | 854 | 1995 |
| The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix M Ohh, RL Yauch, KM Lonergan, JM Whaley, AO Stemmer-Rachamimov, ... Molecular cell 1 (7), 959-968, 1998 | 606 | 1998 |
| Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2 KM Lonergan, O Iliopoulos, M Ohh, T Kamura, RC Conaway, ... Molecular and cellular biology 18 (2), 732-741, 1998 | 525 | 1998 |
| Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells Y Mizukami, WS Jo, EM Duerr, M Gala, J Li, X Zhang, MA Zimmer, ... Nature medicine 11 (9), 992-997, 2005 | 520 | 2005 |
| Belzutifan for renal cell carcinoma in von Hippel–Lindau disease E Jonasch, F Donskov, O Iliopoulos, WK Rathmell, VK Narayan, ... New England Journal of Medicine 385 (22), 2036-2046, 2021 | 403 | 2021 |
| Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL−/− tumors M Zimmer, D Doucette, N Siddiqui, O Iliopoulos Molecular Cancer Research 2 (2), 89-95, 2004 | 351 | 2004 |
| In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation PA Gameiro, J Yang, AM Metelo, R Pérez-Carro, R Baker, Z Wang, ... Cell metabolism 17 (3), 372-385, 2013 | 348 | 2013 |
| pVHL19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation O Iliopoulos, M Ohh, WG Kaelin Jr Proceedings of the National Academy of Sciences 95 (20), 11661-11666, 1998 | 338 | 1998 |
| Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer Y Mizukami, J Li, X Zhang, MA Zimmer, O Iliopoulos, DC Chung Cancer research 64 (5), 1765-1772, 2004 | 253 | 2004 |
| Small-molecule inhibitors of HIF-2a translation link its 5′ UTR iron-responsive element to oxygen sensing M Zimmer, BL Ebert, C Neil, K Brenner, I Papaioannou, A Melas, ... Molecular cell 32 (6), 838-848, 2008 | 229 | 2008 |
| Assessment of overall survival, quality of life, and safety benefits associated with new cancer medicines S Salas-Vega, O Iliopoulos, E Mossialos JAMA oncology 3 (3), 382-390, 2017 | 150 | 2017 |
| Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues CL Corless, AS Kibel, O Iliopoulos, WG Kaelin Jr Human pathology 28 (4), 459-464, 1997 | 150 | 1997 |
| Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential JM Heddleston, Q Wu, M Rivera, S Minhas, JD Lathia, AE Sloan, ... Cell Death & Differentiation 19 (3), 428-439, 2012 | 147 | 2012 |
| Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle*♦ PA Gameiro, LA Laviolette, JK Kelleher, O Iliopoulos, G Stephanopoulos Journal of Biological Chemistry 288 (18), 12967-12977, 2013 | 131 | 2013 |
| von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids B Lieubeau-Teillet, J Rak, S Jothy, O Iliopoulos, W Kaelin, RS Kerbel Cancer research 58 (21), 4957-4962, 1998 | 127 | 1998 |
