| Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase C Vickers, P Hales, V Kaushik, L Dick, J Gavin, J Tang, K Godbout, ... Journal of Biological Chemistry 277 (17), 14838-14843, 2002 | 1879 | 2002 |
| Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in … H Park, VK Kaushik, S Constant, M Prentki, E Przybytkowski, ... Journal of Biological Chemistry 277 (36), 32571-32577, 2002 | 500 | 2002 |
| JNK1 phosphorylates SIRT1 and promotes its enzymatic activity N Nasrin, VK Kaushik, E Fortier, D Wall, KJ Pearson, R De Cabo, ... PloS one 4 (12), e8414, 2009 | 309 | 2009 |
| AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise NB Ruderman, H Park, VK Kaushik, D Dean, S Constant, M Prentki, ... Acta physiologica Scandinavica 178 (4), 435-442, 2003 | 289 | 2003 |
| Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside AK Saha, AJ Schwarsin, R Roduit, F Masse, V Kaushik, K Tornheim, ... Journal of Biological Chemistry 275 (32), 24279-24283, 2000 | 256 | 2000 |
| Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors NA Dales, AE Gould, JA Brown, EF Calderwood, B Guan, CA Minor, ... Journal of the American Chemical Society 124 (40), 11852-11853, 2002 | 219 | 2002 |
| Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease D Klarin, QM Zhu, CA Emdin, M Chaffin, S Horner, BJ McMillan, A Leed, ... Nature genetics 49 (9), 1392-1397, 2017 | 215 | 2017 |
| Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy M Chaffin, I Papangeli, B Simonson, AD Akkad, MC Hill, A Arduini, ... Nature 608 (7921), 174-180, 2022 | 156 | 2022 |
| Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity B Hubbard, H Doege, S Punreddy, H Wu, X Huang, VK Kaushik, ... Gastroenterology 130 (4), 1259-1269, 2006 | 152 | 2006 |
| Small-molecule WNK inhibition regulates cardiovascular and renal function K Yamada, HM Park, DF Rigel, K DiPetrillo, EJ Whalen, A Anisowicz, ... Nature chemical biology 12 (11), 896-898, 2016 | 144 | 2016 |
| A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase S Wellington, PP Nag, K Michalska, SE Johnston, RP Jedrzejczak, ... Nature chemical biology 13 (9), 943-950, 2017 | 125 | 2017 |
| Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR VK Kaushik, ME Young, DJ Dean, TG Kurowski, AK Saha, NB Ruderman American Journal of Physiology-Endocrinology And Metabolism 281 (2), E335-E340, 2001 | 106 | 2001 |
| Mass spectrometric techniques for label-free high-throughput screening in drug discovery TP Roddy, CR Horvath, SJ Stout, KL Kenney, PI Ho, JH Zhang, C Vickers, ... Analytical chemistry 79 (21), 8207-8213, 2007 | 102 | 2007 |
| Identification and characterization of 4-aryl-3, 4-dihydropyrimidin-2 (1H)-ones as inhibitors of the fatty acid transporter FATP4 C Blackburn, B Guan, J Brown, C Cullis, SM Condon, TJ Jenkins, ... Bioorganic & medicinal chemistry letters 16 (13), 3504-3509, 2006 | 97 | 2006 |
| New hypotheses about the structure–function of proprotein convertase subtilisin/kexin type 9: Analysis of the epidermal growth factor‐like repeat A docking site using WaterMap RA Pearlstein, QY Hu, J Zhou, D Yowe, J Levell, B Dale, VK Kaushik, ... Proteins: Structure, Function, and Bioinformatics 78 (12), 2571-2586, 2010 | 90 | 2010 |
| Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease ES Leshchiner, JS Rush, MA Durney, Z Cao, V Dančík, B Chittick, H Wu, ... Proceedings of the National Academy of Sciences 114 (43), 11392-11397, 2017 | 50 | 2017 |
| Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism KJ Kamer, W Jiang, VK Kaushik, VK Mootha, Z Grabarek Proceedings of the National Academy of Sciences 116 (9), 3546-3555, 2019 | 45 | 2019 |
| Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction DC McKinney, BJ McMillan, MJ Ranaghan, JA Moroco, M Brousseau, ... Journal of Medicinal Chemistry 64 (15), 11148-11168, 2021 | 31 | 2021 |
| Coronary disease association with ADAMTS7 is due to protease activity T Mizoguchi, BT MacDonald, B Bhandary, NR Popp, D Laprise, A Arduini, ... Circulation Research 129 (4), 458-470, 2021 | 25 | 2021 |
| Single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (MCL1) C Fang, B D’Souza, CF Thompson, MC Clifton, JW Fairman, B Fulroth, ... ACS medicinal chemistry letters 5 (12), 1308-1312, 2014 | 25 | 2014 |
