Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer’s disease N Guzior, A Wieckowska, D Panek, B Malawska Current medicinal chemistry 22 (3), 373-404, 2015 | 359 | 2015 |
Structure-based search for new inhibitors of cholinesterases M Bajda, A Więckowska, M Hebda, N Guzior, CA Sotriffer, B Malawska International journal of molecular sciences 14 (3), 5608-5632, 2013 | 276 | 2013 |
Development of an in-vivo active reversible butyrylcholinesterase inhibitor U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ... Scientific reports 6 (1), 39495, 2016 | 142 | 2016 |
Microwave-Assisted Synthesis of Weinreb and MAP Aryl Amides via Pd-Catalyzed Heck Aminocarbonylation Using Mo(CO)6 or W(CO)6 A Wieckowska, R Fransson, LR Odell, M Larhed The Journal of Organic Chemistry 76 (3), 978-981, 2011 | 106 | 2011 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta … D Panek, A Więckowska, T Wichur, M Bajda, J Godyń, J Jończyk, K Mika, ... European journal of medicinal chemistry 125, 676-695, 2017 | 93 | 2017 |
Novel multi-target-directed ligands for Alzheimer's disease: combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation A Więckowska, M Kołaczkowski, A Bucki, J Godyń, M Marcinkowska, ... European Journal of Medicinal Chemistry 124, 63-81, 2016 | 85 | 2016 |
Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate … M Andaloussi, LM Henriksson, A Wieckowska, M Lindh, C Bjorkelid, ... Journal of medicinal chemistry 54 (14), 4964-4976, 2011 | 85 | 2011 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo A Więckowska, K Więckowski, M Bajda, B Brus, K Sałat, P Czerwińska, ... Bioorganic & medicinal chemistry 23 (10), 2445-2457, 2015 | 60 | 2015 |
Novel multitarget-directed ligands aiming at symptoms and causes of Alzheimer’s disease A Wieckowska, T Wichur, J Godyń, A Bucki, M Marcinkowska, A Siwek, ... ACS chemical neuroscience 9 (5), 1195-1214, 2018 | 57 | 2018 |
Design, synthesis, and biological evaluation of 1-benzylamino-2-hydroxyalkyl derivatives as new potential disease-modifying multifunctional anti-Alzheimer’s agents D Panek, A Wieckowska, J Jonczyk, J Godyn, M Bajda, T Wichur, ... ACS Chemical Neuroscience 9 (5), 1074-1094, 2018 | 50 | 2018 |
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease T Wichur, A Więckowska, K Więckowski, J Godyń, J Jończyk, ... European Journal of Medicinal Chemistry 187, 111916, 2020 | 48 | 2020 |
Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional … A Pasieka, D Panek, N Szałaj, A Espargaró, A Więckowska, B Malawska, ... ACS Chemical Neuroscience 12 (11), 2057-2068, 2021 | 45 | 2021 |
DXR inhibition by potent mono-and disubstituted fosmidomycin analogues AM Jansson, A Wieckowska, C Bjorkelid, S Yahiaoui, S Sooriyaarachchi, ... Journal of medicinal chemistry 56 (15), 6190-6199, 2013 | 45 | 2013 |
Synthesis, molecular modelling and biological evaluation of novel heterodimeric, multiple ligands targeting cholinesterases and amyloid beta M Hebda, M Bajda, A Więckowska, N Szałaj, A Pasieka, D Panek, ... Molecules 21 (4), 410, 2016 | 36 | 2016 |
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis M Andaloussi, M Lindh, C Björkelid, S Suresh, A Wieckowska, H Iyer, ... Bioorganic & medicinal chemistry letters 21 (18), 5403-5407, 2011 | 34 | 2011 |
Dual‐Acting Diether Derivatives of Piperidine and Homopiperidine with Histamine H3 Receptor Antagonistic and Anticholinesterase Activity M Bajda, KJ Kuder, D Łażewska, K Kieć‐Kononowicz, A Więckowska, ... Archiv der Pharmazie 345 (8), 591-597, 2012 | 33 | 2012 |
Design, synthesis, and biological evaluation of 2-(benzylamino-2-hydroxyalkyl) isoindoline-1, 3-diones derivatives as potential disease-modifying multifunctional anti-Alzheimer … D Panek, A Więckowska, A Pasieka, J Godyń, J Jończyk, M Bajda, D Knez, ... Molecules 23 (2), 347, 2018 | 31 | 2018 |
Novel alkyl-and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors A Więckowska, M Bajda, N Guzior, B Malawska European journal of medicinal chemistry 45 (12), 5602-5611, 2010 | 31 | 2010 |
Novel aryloxyethyl derivatives of 1-(1-benzoylpiperidin-4-yl) methanamine as the extracellular regulated kinases 1/2 (ERK1/2) phosphorylation-preferring serotonin 5-HT1A … J Sniecikowska, M Gluch-Lutwin, A Bucki, A Wieckowska, A Siwek, ... Journal of Medicinal Chemistry 62 (5), 2750-2771, 2019 | 29 | 2019 |
Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors K Kulig, K Więckowski, A Więckowska, J Gajda, B Pochwat, GC Höfner, ... European journal of medicinal chemistry 46 (1), 183-190, 2011 | 26 | 2011 |