The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections N Abdel Aziz, JK Nono, T Mpotje, F Brombacher PLoS biology 16 (10), e2005850, 2018 | 39 | 2018 |
Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha JK Nono, H Ndlovu, NA Aziz, T Mpotje, L Hlaka, F Brombacher PLoS neglected tropical diseases 11 (8), e0005861, 2017 | 27 | 2017 |
Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models JK Nono, K Fu, T Mpotje, G Varrone, NA Aziz, P Mosala, L Hlaka, ... Scientific reports 10 (1), 10638, 2020 | 25 | 2020 |
Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases R Guler, T Mpotje, M Ozturk, JK Nono, SP Parihar, JE Chia, NA Aziz, ... Mucosal immunology 12 (2), 390-402, 2019 | 22 | 2019 |
Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses F Musaigwa, SD Kamdem, T Mpotje, P Mosala, N Abdel Aziz, ... PLoS Pathogens 18 (2), e1010327, 2022 | 16 | 2022 |
Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection JK Nono, H Ndlovu, N Abdel Aziz, T Mpotje, L Hlaka, F Brombacher PLoS Neglected Tropical Diseases 11 (6), e0005675, 2017 | 14 | 2017 |
Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection JK Nono, T Mpotje, P Mosala, NA Aziz, F Musaigwa, L Hlaka, ... Frontiers in Immunology 12, 748387, 2021 | 7 | 2021 |
IL-4i1 Regulation of Immune Protection During Mycobacterium tuberculosis Infection L Hlaka, M Ozturk, JE Chia, SS Jones, S Pillay, SKL Poswayo, T Mpotje, ... The Journal of Infectious Diseases 224 (12), 2170-2180, 2021 | 5 | 2021 |
IL-4Rα deletion disrupts psychomotor performance and reference memory in mice while sparing behavioural phenotype associated with spatial learning TM Brombacher, DC Ajonijebu, M Scibiorek, I Berkiks, BO Moses, ... Brain, Behavior, and Immunity 92, 157-164, 2021 | 5 | 2021 |
Investigating neutrophil cell death in TB pathogenesis KL Fisher, K Rajkumar-Bhugeloo, D Moodley, T Mpotje, D Ramsuran, ... Gates open research 5, 2021 | 4 | 2021 |
Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood AM Rapulana, T Mpotje, OO Baiyegunhi, H Ndlovu, TK Smit, TD McHugh, ... Frontiers in Molecular Medicine 4, 1345510, 2024 | 1 | 2024 |
The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice TRV Mpotje | 1 | 2021 |
Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model P Mosala, T Mpotje, N Abdel Aziz, H Ndlovu, F Musaigwa, JK Nono, ... Frontiers in Immunology 15, 1279043, 2024 | | 2024 |
Host determinants of TB disease as targets for HDTs development: A study protocol K Rajkumar-Bhugeloo, D Moodley, T Mpotje, MJ Marakalala Wellcome Open Research 8 (116), 116, 2023 | | 2023 |
Gasdermin D associates with cellular regions bordering NETosis enrichment in human TB granulomas K Fisher, K Nargan, D Moodley, T Mpotje, A Steyn, T Ndung'u, ... | | 2023 |
Validation of proteins associated with pathological damage in human tuberculosis granulomas: study protocol T Mpotje, J More, K Rajkumar-Bhugeloo, D Moodley, MJ Marakalala Wellcome Open Research 8, 2023 | | 2023 |
IL-4R alpha is required by Foxp3 (+) regulatory T cells to control tissue inflammation AN Aziz, JK Nono, T Mpotje, P Mosala, F Brombacher EUROPEAN JOURNAL OF IMMUNOLOGY 49, 697-697, 2019 | | 2019 |
The absence of cysLTR1 ameliorates liver granulomatous inflammation during acute schistosomiasis in mice P Mosala, T Mpotje, AN Aziz, H Ndlovu, J Nono, F Brombacher EUROPEAN JOURNAL OF IMMUNOLOGY 49, 1195-1196, 2019 | | 2019 |
The role of BATF2 during of experimental murine Schistosomiasis TRV Mpotje | | 2017 |