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Shauna O'Donovan
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Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator
SD O’Donovan, M Lenz, GH Goossens, CJH van der Kallen, ...
Scientific reports 9 (1), 9388, 2019
342019
A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data
SD O’Donovan, M Lenz, RG Vink, NJT Roumans, TMCM de Kok, ...
PLoS computational biology 15 (10), e1007400, 2019
182019
Transcriptomic signature of fasting in human adipose tissue
M Defour, CCJR Michielsen, SD O’donovan, LA Afman, S Kersten
Physiological genomics 52 (10), 451-467, 2020
172020
Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge
B Erdős, B van Sloun, ME Adriaens, SD O’Donovan, D Langin, A Astrup, ...
PLoS Computational Biology 17 (3), e1008852, 2021
152021
Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes
SD O’Donovan, K Driessens, D Lopatta, F Wimmenauer, A Lukas, ...
Plos one 15 (8), e0236392, 2020
52020
Analysis of high-dimensional metabolomics data with complex temporal dynamics using RM-ASCA+
B Erdős, JA Westerhuis, ME Adriaens, SD O’Donovan, R Xie, ...
PLOS Computational Biology 19 (6), e1011221, 2023
42023
E-DES-PROT: A novel computational model to describe the effects of amino acids and protein on postprandial glucose and insulin dynamics in humans
B van Sloun, GH Goossens, B Erdõs, SD O’Donovan, CM Singh-Povel, ...
Iscience 26 (3), 2023
42023
Quantifying the contribution of triglycerides to metabolic resilience through the mixed meal model
SD O’Donovan, B Erdős, DM Jacobs, AJ Wanders, EL Thomas, JD Bell, ...
Iscience 25 (11), 2022
42022
Deep learning methods to translate gene expression changes induced in vitro in rat hepatocytes to human in vivo
TM de Kok, S O'Donovan, M Lenz, F Wimmenauer, A Lukas, J Neeven, ...
Toxicology Letters 314, S170-S170, 2019
22019
Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study
B Erdős, B van Sloun, GH Goossens, SD O’Donovan, BE de Galan, ...
Plos one 18 (7), e0285820, 2023
12023
Quantifying the effect of nutritional interventions on metabolic resilience using personalized computational models
SD O’Donovan, M Rundle, EL Thomas, JD Bell, G Frost, DM Jacobs, ...
Iscience 27 (4), 2024
2024
Leveraging continuous glucose monitoring for personalized modeling of insulin-regulated glucose metabolism
B Erdős, SD O’Donovan, ME Adriaens, A Gijbels, I Trouwborst, KM Jardon, ...
Scientific Reports 14 (1), 8037, 2024
2024
Physiology-informed regularization enables training of universal differential equation systems for biological applications
M de Rooij, B Erdos, N van Riel, S O'Donovan
bioRxiv, 2024.05. 28.596164, 2024
2024
Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data
SD O’Donovan, R Cavill, F Wimmenauer, A Lukas, T Stumm, E Smirnov, ...
Plos one 18 (11), e0292030, 2023
2023
Accelerating Dynamic Modelling and Parameter Estimation in Biology using the Julia Programming Language
M de Rooij, B Erdős, NAW van Riel, S O'Donovan
2023
From Population to Personalized Physiological Models: Parameter Estimation Approaches in a Physiology-Constrained Simulation Study
R de Vries, S O'Donovan, NAW van Riel
2023
The Mixed Meal Model: quantifying the contribution of 1 triglycerides to metabolic resilience.
SD O’Donovan, B Erdős, DM Jacobs, AJ Wanders, EL Thomas, JD Bell, ...
iScience 25 (11), 2022
2022
Metabolic Reprogramming of the Innate Immune System
S O'Donovan, N Valenbreder, NAW van Riel
8th Dutch Bioinformatics & Systems Biology Conference, 2022
2022
The Mixed Meal Model; towards precision nutrition in overweight and obesity.
S O'Donovan, ICW Arts, L Afman, NAW van Riel
8th Dutch Bioinformatics & Systems Biology Conference, 2022
2022
The M3al Model; towards precision nutrition in overweight an obesity.
S O'Donovan, R de Vries, ICW Arts, NAW van Riel, L Afman
NuGO week 2021, 2021
2021
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