关注
Xiaochun Li
Xiaochun Li
在 utsouthwestern.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Structure and mechanism of an amino acid antiporter
X Gao, F Lu, L Zhou, S Dang, L Sun, X Li, J Wang, Y Shi
Science 324 (5934), 1565-1568, 2009
2502009
Structure of a presenilin family intramembrane aspartate protease
X Li, S Dang, C Yan, X Gong, J Wang, Y Shi
Nature 493 (7430), 56-61, 2013
2312013
Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2
X Li, P Saha, J Li, G Blobel, SR Pfeffer
Proceedings of the National Academy of Sciences 113 (36), 10079-10084, 2016
1812016
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies
SM Condon, Y Mitsuuchi, Y Deng, MG LaPorte, SR Rippin, T Haimowitz, ...
Journal of medicinal chemistry 57 (9), 3666-3677, 2014
1752014
Structure of human Niemann–Pick C1 protein
X Li, J Wang, E Coutavas, H Shi, Q Hao, G Blobel
Proceedings of the National Academy of Sciences 113 (29), 8212-8217, 2016
1742016
Structures of human Patched and its complex with native palmitoylated sonic hedgehog
X Qi, P Schmiege, E Coutavas, J Wang, X Li
Nature 560 (7716), 128-132, 2018
1722018
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
X Qi, H Liu, B Thompson, J McDonald, C Zhang, X Li
Nature 571 (7764), 279-283, 2019
1482019
Human TRPML1 channel structures in open and closed conformations
P Schmiege, M Fine, G Blobel, X Li
Nature 550 (7676), 366-370, 2017
1392017
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex
X Qi, P Schmiege, E Coutavas, X Li
Science 362 (6410), eaas8843, 2018
1232018
Molecular basis of V-ATPase inhibition by bafilomycin A1
R Wang, J Wang, A Hassan, CH Lee, XS Xie, X Li
Nature communications 12 (1), 1782, 2021
1052021
3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport
X Li, F Lu, MN Trinh, P Schmiege, J Seemann, J Wang, G Blobel
Proceedings of the National Academy of Sciences 114 (34), 9116-9121, 2017
1042017
Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage
X Li, B Wang, L Feng, H Kang, Y Qi, J Wang, Y Shi
Proceedings of the National Academy of Sciences 106 (35), 14837-14842, 2009
802009
Structural basis for PtdInsP2-mediated human TRPML1 regulation
M Fine, P Schmiege, X Li
Nature Communications 9 (1), 4192, 2018
732018
Mechanistic insights into the generation and transduction of hedgehog signaling
X Qi, X Li
Trends in biochemical sciences 45 (5), 397-410, 2020
722020
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
X Qi, L Friedberg, R De Bose-Boyd, T Long, X Li
Nature chemical biology 16 (12), 1368-1375, 2020
672020
Structural basis for itraconazole-mediated NPC1 inhibition
T Long, X Qi, A Hassan, Q Liang, JK De Brabander, X Li
Nature communications 11 (1), 152, 2020
672020
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1
MN Trinh, F Lu, X Li, A Das, Q Liang, JK De Brabander, MS Brown, ...
Proceedings of the National Academy of Sciences 114 (1), 89-94, 2017
672017
Structure of nevanimibe-bound tetrameric human ACAT1
T Long, Y Sun, A Hassan, X Qi, X Li
Nature 581 (7808), 339-343, 2020
662020
Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition
T Long, A Hassan, BM Thompson, JG McDonald, J Wang, X Li
Nature communications 10 (1), 2452, 2019
592019
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum
X Li, R Roberti, G Blobel
Nature 517 (7532), 104-107, 2015
592015
系统目前无法执行此操作,请稍后再试。
文章 1–20