Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target D Liu, CC Wong, L Fu, H Chen, L Zhao, C Li, Y Zhou, Y Zhang, W Xu, ... Science translational medicine 10 (437), eaap9840, 2018 | 221 | 2018 |
Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) Y Kong, L Cheng, F Mao, Z Zhang, Y Zhang, E Farah, J Bosler, Y Bai, ... Journal of Biological Chemistry 293 (37), 14328-14341, 2018 | 97 | 2018 |
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis WW Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z Oncogene, 2015 | 92 | 2015 |
p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer J Liu, D He, L Cheng, C Huang, Y Zhang, X Rao, Y Kong, C Li, Z Zhang, ... Oncogene 39 (19), 3939-3951, 2020 | 86 | 2020 |
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes D Lu, Y Wu, Y Wang, F Ren, D Wang, F Su, Y Zhang, X Yang, G Jin, ... Cancer cell 21 (1), 92-104, 2012 | 86 | 2012 |
RNF6 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of TLE3 L Liu, Y Zhang, CC Wong, J Zhang, Y Dong, X Li, W Kang, FKL Chan, ... Cancer research 78 (8), 1958-1971, 2018 | 83 | 2018 |
TRIM67 activates p53 to suppress colorectal cancer initiation and progression S Wang, Y Zhang, J Huang, CC Wong, J Zhai, C Li, G Wei, L Zhao, ... Cancer research 79 (16), 4086-4098, 2019 | 82 | 2019 |
Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells WR Li, L Chen, ZJ Chang, H Xin, T Liu, YQ Zhang, GY Li, F Zhou, ... Asian journal of andrology 13 (6), 881, 2011 | 80 | 2011 |
Forkhead Box F2 suppresses gastric cancer through a novel FOXF2–IRF2BPL–β-catenin signaling axis A Higashimori, Y Dong, Y Zhang, W Kang, G Nakatsu, SSM Ng, ... Cancer research 78 (7), 1643-1656, 2018 | 70 | 2018 |
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma Y Shang, J He, Y Wang, Q Feng, Y Zhang, J Guo, J Li, S Li, G Yan, F Ren, ... Oncogene 36 (29), 4191-4200, 2017 | 70 | 2017 |
DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer S Wang, Y Dong, Y Zhang, X Wang, L Xu, S Yang, X Li, H Dong, L Su, ... Oncogene 34 (20), 2575-2585, 2015 | 67 | 2015 |
Sodium channel subunit SCNN1B suppresses gastric cancer growth and metastasis via GRP78 degradation Y Qian, CC Wong, J Xu, H Chen, Y Zhang, W Kang, H Wang, L Zhang, ... Cancer research 77 (8), 1968-1982, 2017 | 61 | 2017 |
Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis JY Jinghua Du, Xiang Zhang, Juqiang Han, Kwan Man, Yanquan Zhang, Eagle SH ... Theranostics 7 (17), 4192-42-3, 2017 | 61 | 2017 |
GABARAPL1 negatively regulates Wnt/β-catenin signaling by mediating Dvl2 degradation through the autophagy pathway Y Zhang, F Wang, L Han, Y Wu, S Li, X Yang, Y Wang, F Ren, Y Zhai, ... Cellular Physiology and Biochemistry 27 (5), 503-512, 2011 | 59 | 2011 |
NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells E Farah, C Li, L Cheng, Y Kong, NA Lanman, P Pascuzzi, GR Lorenz, ... Journal of Biological Chemistry 294 (21), 8543-8554, 2019 | 56 | 2019 |
CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin· TCF4 transcriptional activity in response to Wnt signaling Y Zhang, C Liu, X Duan, F Ren, S Li, Z Jin, Y Wang, Y Feng, Z Liu, ... Journal of Biological Chemistry 289 (33), 22589-22599, 2014 | 53 | 2014 |
p15RS attenuates Wnt/β-catenin signaling by disrupting β-catenin· TCF4 interaction Y Wu, Y Zhang, H Zhang, X Yang, Y Wang, F Ren, H Liu, Y Zhai, B Jia, ... Journal of Biological Chemistry 285 (45), 34621-34631, 2010 | 50 | 2010 |
FGFR3 induces degradation of BMP type I receptor to regulate skeletal development H Qi, M Jin, Y Duan, X Du, Y Zhang, F Ren, Y Wang, Q Tian, X Wang, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (7), 1237-1247, 2014 | 49 | 2014 |
CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation Y Zhang, S Wang, W Kang, C Liu, Y Dong, F Ren, Y Wang, J Zhang, ... Oncogene 37 (26), 3485-3500, 2018 | 48 | 2018 |
Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A L Cao, S Wang, Y Zhang, KC Wong, G Nakatsu, X Wang, S Wong, J Ji, ... Oncogene 37 (26), 3601-3616, 2018 | 47 | 2018 |