An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis B Boisson, C Wang, V Pedergnana, L Wu, S Cypowyj, M Rybojad, ... Immunity 39 (4), 676-686, 2013 | 295 | 2013 |
Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells Z Kang, C Wang, J Zepp, L Wu, K Sun, J Zhao, U Chandrasekharan, ... Nature neuroscience 16 (10), 1401-1408, 2013 | 228 | 2013 |
Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1 HY Li, H Liu, CH Wang, JY Zhang, JH Man, YF Gao, PJ Zhang, WH Li, ... Nature immunology 9 (5), 533-541, 2008 | 171 | 2008 |
T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis BN Martin, C Wang, C Zhang, Z Kang, MF Gulen, JA Zepp, J Zhao, G Bian, ... Nature immunology 17 (5), 583-592, 2016 | 163 | 2016 |
IKKα negatively regulates ASC-dependent inflammasome activation BN Martin, C Wang, J Willette-Brown, T Herjan, MF Gulen, H Zhou, ... Nature communications 5 (1), 4977, 2014 | 123 | 2014 |
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 C Wang, L Wu, K Bulek, BN Martin, JA Zepp, Z Kang, C Liu, T Herjan, ... Nature immunology 14 (1), 72-81, 2013 | 108 | 2013 |
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination Z Kang, L Liu, R Spangler, C Spear, C Wang, MF Gulen, M Veenstra, ... Journal of Neuroscience 32 (24), 8284-8292, 2012 | 97 | 2012 |
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression C Wang, CJ Zhang, BN Martin, K Bulek, Z Kang, J Zhao, G Bian, ... Nature Communications 8 (1), 15508, 2017 | 95 | 2017 |
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, ... The Journal of clinical investigation 128 (12), 5399-5412, 2018 | 90 | 2018 |
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin− c-Kit+ innate cell population Z Kang, S Swaidani, W Yin, C Wang, JL Barlow, MF Gulen, K Bulek, J Do, ... Immunity 36 (5), 821-833, 2012 | 77 | 2012 |
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo C Liu, L Zhu, K Fukuda, S Ouyang, X Chen, C Wang, C Zhang, B Martin, ... Science signaling 10 (467), eaaf8823, 2017 | 75 | 2017 |
A CC′ loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17–and IL-25–induced inflammation C Liu, S Swaidani, W Qian, Z Kang, P Sun, Y Han, C Wang, MF Gulen, ... Science signaling 4 (197), ra72-ra72, 2011 | 59 | 2011 |
Tumor-targeted delivery of biologically active TRAIL protein HY Zhang, JH Man, B Liang, T Zhou, CH Wang, T Li, HY Li, WH Li, BF Jin, ... Cancer gene therapy 17 (5), 334-343, 2010 | 51 | 2010 |
A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants Y Du, R Shi, Y Zhang, X Duan, L Li, J Zhang, F Wang, R Zhang, H Shen, ... Nature communications 12 (1), 5000, 2021 | 45 | 2021 |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 CJ Zhang, C Wang, M Jiang, C Gu, J Xiao, X Chen, BN Martin, F Tang, ... Nature communications 9 (1), 2745, 2018 | 40 | 2018 |
NINJ2–A novel regulator of endothelial inflammation and activation J Wang, J Fa, P Wang, X Jia, H Peng, J Chen, Y Wang, C Wang, Q Chen, ... Cellular signalling 35, 231-241, 2017 | 38 | 2017 |
Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock‐in rat model C Cheng, H Liu, C Tan, D Tong, Y Zhao, X Liu, W Si, L Wang, L Liang, J Li, ... The FASEB Journal 33 (8), 8878-8891, 2019 | 35 | 2019 |
The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling L Wu, C Wang, B Boisson, S Misra, P Rayman, JH Finke, A Puel, ... The Journal of Immunology 193 (4), 1590-1599, 2014 | 30 | 2014 |
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis H Zhang, Z Cui, D Cheng, Y Du, X Guo, R Gao, J Chen, W Sun, R He, ... Autophagy 17 (10), 3030-3047, 2021 | 28 | 2021 |
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response J Chen, R He, W Sun, R Gao, Q Peng, L Zhu, Y Du, X Ma, X Guo, H Zhang, ... Nature Communications 11 (1), 1913, 2020 | 28 | 2020 |