Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens RM Karvas, SA Khan, S Verma, Y Yin, D Kulkarni, C Dong, K Park, ... Cell Stem Cell 29 (5), 810-825. e8, 2022 | 84 | 2022 |
Eph/ephrin interactions modulate muscle satellite cell motility and patterning DA Stark, RM Karvas, AL Siegel, DDW Cornelison Development 138 (24), 5279-5289, 2011 | 75 | 2011 |
Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells D Thotala, RM Karvas, JA Engelbach, JR Garbow, AN Hallahan, ... Oncotarget 6 (33), 35004, 2015 | 64 | 2015 |
Autotaxin inhibition with PF-8380 enhances the radiosensitivity of human and murine glioblastoma cell lines SR Bhave, DYA Dadey, RM Karvas, DJ Ferraro, RP Kotipatruni, JJ Jaboin, ... Frontiers in oncology 3, 236, 2013 | 55 | 2013 |
3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages RM Karvas, JE Zemke, SS Ali, E Upton, E Sane, LA Fischer, C Dong, ... Cell Stem Cell 30 (9), 1148-1165. e7, 2023 | 37 | 2023 |
Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast RM Karvas, S McInturf, J Zhou, T Ezashi, DJ Schust, RM Roberts, ... Molecular human reproduction 26 (6), 425-440, 2020 | 28 | 2020 |
A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells C Dong, S Fu, RM Karvas, B Chew, LA Fischer, X Xing, JK Harrison, ... Nature communications 13 (1), 2548, 2022 | 26 | 2022 |
Accessing the human trophoblast stem cell state from pluripotent and somatic cells RM Karvas, L David, TW Theunissen Cellular and Molecular Life Sciences 79 (12), 604, 2022 | 6 | 2022 |
Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously M Guo, J Wu, C Chen, X Wang, A Gong, W Guan, RM Karvas, K Wang, ... Nature communications 15 (1), 668, 2024 | 3 | 2024 |
Generation of 3D trophoblast organoids from human naïve pluripotent stem cells RM Karvas, TW Theunissen Embryo Models In Vitro: Methods and Protocols, 85-103, 2023 | 3 | 2023 |
The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model … J Zhou, Y Tian, Y Qu, M Williams, Y Yuan, RM Karvas, MA Sheridan, ... Frontiers in endocrinology 14, 1069395, 2023 | 3 | 2023 |
ITGA1 is upregulated in response to oxygen over time in a BMP4 model of trophoblast RM Karvas, Y Yang, T Ezashi, DJ Schust, RM Roberts, LC Schulz Molecular reproduction and development 85 (8-9), 738, 2018 | 3 | 2018 |
The Egr1 transcription factor contributes to radiation-induced apoptosis in the mouse hippocampus and intestinal crypts DY Zhao, KM Jacobs, RM Karvas, JL Joubert, DE Hallahan, D Thotala Cancer Research 74 (19_Supplement), 3941-3941, 2014 | 2 | 2014 |
Modeling preeclampsia: an emerging role for stem cells AJ Stephens, RM Karvas, K Adachi, LC Schulz, DJ Schust NeoReviews 15 (12), e526-e536, 2014 | 1 | 2014 |
Derivation of trophoblast organoids from naive human pluripotent stem cells T Theunissen, R Karvas US Patent App. 18/312,488, 2023 | | 2023 |
Generation of trophoblast models from human pluripotent stem cells: insights into the signaling requirements of human placental stem cells. R Karvas Placenta 140, e18-e19, 2023 | | 2023 |
3D-cultured human blastoids model trophoblast expansion, diversification, and invasion during early post-implantation development R Karvas, J Zemke, S Ali, E Sane, L Fischer, C Dong, K Park, E Upton, ... Placenta 140, e26, 2023 | | 2023 |
Characterizing a model of early human placenta RM Karvas University of Missouri-Columbia, 2020 | | 2020 |
Cover Image, Volume 85, Issue 8–9, August 2018 RM Karvas, Y Yang, T Ezashi, DJ Schust, RM Roberts, LC Schulz Molecular Reproduction and Development 85 (8-9), i-i, 2018 | | 2018 |
The inhibitory T cell co-receptor molecule B7-H4 (VTCN1) regulates major histocompatibility complex class I expression in a stem cell-derived model of primitive human … J Zhou, R Karvas, L Schulz, T Ezashi, RM Roberts, D Schust HUMAN REPRODUCTION 33, 362-362, 2018 | | 2018 |