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Ralph A Nixon
Ralph A Nixon
Professor of Psychiatry and Cell Biology New York University
在 nki.rfmh.org 的电子邮件经过验证
标题
引用次数
引用次数
年份
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ...
Autophagy 8 (4), 445-544, 2012
13300*2012
The role of autophagy in neurodegenerative disease
RA Nixon
Nature medicine 19 (8), 983-997, 2013
21252013
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
C Janus, J Pearson, JA McLaurin, PM Mathews, Y Jiang, SD Schmidt, ...
Nature 408 (6815), 979-982, 2000
20302000
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
RA Nixon, J Wegiel, A Kumar, WH Yu, C Peterhoff, A Cataldo, AM Cuervo
Journal of Neuropathology & Experimental Neurology 64 (2), 113-122, 2005
17432005
Alzheimer disease
DS Knopman, H Amieva, RC Petersen, G Chételat, DM Holtzman, ...
Nature reviews Disease primers 7 (1), 33, 2021
12862021
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
JH Lee, WH Yu, A Kumar, S Lee, PS Mohan, CM Peterhoff, DM Wolfe, ...
Cell 141 (7), 1146-1158, 2010
12592010
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
B Boland, A Kumar, S Lee, FM Platt, J Wegiel, WH Yu, RA Nixon
Journal of Neuroscience 28 (27), 6926-6937, 2008
12352008
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ...
The Journal of cell biology 171 (1), 87-98, 2005
11642005
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
AM Cataldo, CM Peterhoff, JC Troncoso, T Gomez-Isla, BT Hyman, ...
The American journal of pathology 157 (1), 277-286, 2000
9392000
Autophagy, amyloidogenesis and Alzheimer disease
RA Nixon
Journal of cell science 120 (23), 4081-4091, 2007
8842007
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
K Saito, JS Elce, JE Hamos, RA Nixon
Proceedings of the National Academy of Sciences 90 (7), 2628-2632, 1993
7291993
Autophagy failure in Alzheimer's disease—locating the primary defect
RA Nixon, DS Yang
Neurobiology of disease 43 (1), 38-45, 2011
6952011
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
A Salehi, JD Delcroix, PV Belichenko, K Zhan, C Wu, JS Valletta, ...
Neuron 51 (1), 29-42, 2006
6082006
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
DK Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K ...
Neuron 38 (4), 555-65, 2003
583*2003
Autophagy and its possible roles in nervous system diseases, damage and repair
DC Rubinsztein, M DiFiglia, N Heintz, RA Nixon, ZH Qin, B Ravikumar, ...
Autophagy 1 (1), 11-22, 2005
5512005
Neurofilaments and neurofilament proteins in health and disease
A Yuan, MV Rao, RA Nixon
Cold Spring Harbor perspectives in biology 9 (4), a018309, 2017
5482017
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.
AM Cataldo, RA Nixon
Proceedings of the National Academy of Sciences 87 (10), 3861-3865, 1990
5461990
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis
AM Cataldo, JL Barnett, C Pieroni, RA Nixon
Journal of Neuroscience 17 (16), 6142-6151, 1997
5191997
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
S Lee, Y Sato, RA Nixon
Journal of Neuroscience 31 (21), 7817-7830, 2011
5152011
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
DS Yang, P Stavrides, PS Mohan, S Kaushik, A Kumar, M Ohno, ...
Brain 134 (1), 258-277, 2011
4972011
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