On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all? Y Ruan, Z Luo, X Tang, G Li, H Wen, X He, X Lu, J Lu, CI Wu National Science Review 8 (1), nwaa246, 2021 | 35 | 2021 |
On the origin of SARS-CoV-2—the blind watchmaker argument CI Wu, H Wen, J Lu, X Su, AC Hughes, W Zhai, C Chen, H Chen, M Li, ... Science China Life Sciences 64, 1560-1563, 2021 | 28 | 2021 |
The twin-beginnings of COVID-19 in Asia and Europe—one prevails quickly Y Ruan, H Wen, M Hou, Z He, X Lu, Y Xue, X He, YP Zhang, CI Wu National Science Review 9 (4), nwab223, 2022 | 27 | 2022 |
A theoretical exploration of the origin and early evolution of a pandemic Y Ruan, H Wen, X He, CI Wu Science Bulletin 66 (10), 1022-1029, 2021 | 25 | 2021 |
The runaway evolution of SARS-CoV-2 leading to the highly evolved Delta strain Y Ruan, M Hou, X Tang, X He, X Lu, J Lu, CI Wu, H Wen Molecular Biology and Evolution 39 (3), msac046, 2022 | 19 | 2022 |
Mutations beget more mutations—rapid evolution of mutation rate in response to the risk of runaway accumulation Y Ruan, H Wang, B Chen, H Wen, CI Wu Molecular Biology and Evolution 37 (4), 1007-1019, 2020 | 17* | 2020 |
Prevalence and spectrum of DNA mismatch repair gene variation in the general Chinese population L Zhang, Z Qin, T Huang, B Tam, Y Ruan, M Guo, X Wu, J Li, B Zhao, ... Journal of Medical Genetics 59 (7), 652-661, 2022 | 8 | 2022 |
Intra-vs. interhost evolution of SARS-CoV-2 driven by uncorrelated selection—the evolution thwarted M Hou, J Shi, Z Gong, H Wen, Y Lan, X Deng, Q Fan, J Li, M Jiang, ... Molecular Biology and Evolution 40 (9), msad204, 2023 | 5 | 2023 |
Very large hidden genetic diversity in one single tumor: evidence for tumors-in-tumor B Chen, X Wu, Y Ruan, Y Zhang, Q Cai, L Zapata, CI Wu, P Lan, H Wen National science review 9 (12), nwac250, 2022 | 5 | 2022 |
One viral sequence for each host?–The neglected within-host diversity as the main stage of SARS-CoV-2 evolution Y Ruan, M Hou, J Li, Y Song, HYI Wang, X He, H Zeng, J Lu, H Wen, ... bioRxiv, 2021.06. 21.449205, 2021 | 4 | 2021 |
Sex, fitness decline and recombination–Muller’s ratchet vs. Ohta’s ratchet Y Ruan, H Wang, L Zhang, H Wen, CI Wu BioRxiv, 2020.08. 06.240713, 2020 | 4 | 2020 |
On the epicenter of COVID-19 and the origin of the pandemic strain Y Ruan, H Wen, M Hou, W Zhai, S Xu, X Lu National Science Review 10 (4), nwac286, 2023 | 3 | 2023 |
Dynamic global analysis of transcription reveals the role of miRNAs in synergistic stabilization of gene expression F Ma, GA Lu, Q Chen, Y Ruan, X Li, X Lu, C Li Science Bulletin 65 (24), 2130-2140, 2020 | 3 | 2020 |
Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2 DC Lee, JH Tai, HF Lin, TL Chao, Y Ruan, YW Cheng, YC Chou, YY Lin, ... bioRxiv, 2023.02. 10.527437, 2023 | 2 | 2023 |
Resolving Paradoxes in Molecular Evolution: The Integrated WF-Haldane (WFH) Model of Genetic Drift Y Ruan, X Wang, M Hou, W Diao, S Xu, H Wen, CI Wu bioRxiv, 2024.02. 19.581083, 2024 | 1 | 2024 |
Tradeoffs between proliferation and transmission in virus evolution--insights from evolutionary and functional analyses of SARS-CoV-2 JH Tai, DC Lee, HF Lin, TL Chao, Y Ruan, YW Cheng, YC Chou, YY Lin, ... ESS Open Archive eprints 536, 53682369, 2024 | | 2024 |
The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems X Wang, Y Ruan, L Zhang, X Chen, Z Shi, H Wang, B Chen, ME Tracy, ... bioRxiv, 2023.06. 14.545040, 2023 | | 2023 |