The enzymes of β-lactam biosynthesis RB Hamed, JR Gomez-Castellanos, L Henry, C Ducho, MA McDonough, ... Natural product reports 30 (1), 21-107, 2013 | 238 | 2013 |
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans W Ge, A Wolf, T Feng, C Ho, R Sekirnik, A Zayer, N Granatino, ... Nature chemical biology 8 (12), 960-962, 2012 | 187 | 2012 |
Mechanisms and structures of crotonase superfamily enzymes–how nature controls enolate and oxyanion reactivity RB Hamed, ET Batchelar, IJ Clifton, CJ Schofield Cellular and Molecular Life Sciences 65, 2507-2527, 2008 | 134 | 2008 |
Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen E Flashman, LM Hoffart, RB Hamed, JM Bollinger Jr, C Krebs, ... The FEBS journal 277 (19), 4089-4099, 2010 | 112 | 2010 |
Factor‐inhibiting hypoxia‐inducible factor (FIH) catalyses the post‐translational hydroxylation of histidinyl residues within ankyrin repeat domains M Yang, R Chowdhury, W Ge, RB Hamed, MA McDonough, ... FEBS Journal 278 (7), 1086-1097, 2011 | 89 | 2011 |
Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo SV Sharma, X Tong, C Pubill-Ulldemolins, C Cartmell, EJA Bogosyan, ... Nature communications 8 (1), 229, 2017 | 66 | 2017 |
Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. R Hopkinson, R Hamed, N Rose, T Claridge, C Schofield Chembiochem: a European journal of chemical biology 11 (4), 2010 | 65 | 2010 |
Iron‐Mediated Cleavage of C C Bonds in Vicinal Tricarbonyl Compounds in Water J Mecinović, RB Hamed, CJ Schofield Angewandte Chemie International Edition 48 (15), 2796-2800, 2009 | 63 | 2009 |
The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. M Mantri, ND Loik, RB Hamed, TD Claridge, JS McCullagh, CJ Schofield Chembiochem: a European journal of chemical biology 12 (4), 531-534, 2011 | 61 | 2011 |
Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions D Rotili, M Altun, RB Hamed, C Loenarz, A Thalhammer, RJ Hopkinson, ... Chemical Communications 47 (5), 1488-1490, 2011 | 45 | 2011 |
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S, 5S)-trans-carboxymethylproline RB Hamed, ET Batchelar, J Mecinovic, TDW Claridge, CJ Schofield ChemBioChem 10 (2), 246, 2009 | 33 | 2009 |
Crotonase catalysis enables flexible production of functionalized prolines and carbapenams RB Hamed, L Henry, JR Gomez-Castellanos, J Mecinovic, C Ducho, ... Journal of the American Chemical Society 134 (1), 471-479, 2012 | 30 | 2012 |
Thioester Hydrolysis and C C Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily ET Batchelar, RB Hamed, C Ducho, TDW Claridge, MJ Edelmann, ... Angewandte Chemie International Edition 47 (48), 9322-9325, 2008 | 30 | 2008 |
Stereoselective C–C bond formation catalysed by engineered carboxymethylproline synthases RB Hamed, JR Gomez-Castellanos, A Thalhammer, D Harding, C Ducho, ... Nature chemistry 3 (5), 365-371, 2011 | 29 | 2011 |
Synthesis of regio-and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis C Ducho, RB Hamed, ET Batchelar, JL Sorensen, B Odell, CJ Schofield Organic & Biomolecular Chemistry 7 (13), 2770-2779, 2009 | 27 | 2009 |
A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A CS Bailey, JS Zarins-Tutt, M Agbo, H Gao, A Diego-Taboada, M Gan, ... Chemical Science 10 (32), 7549-7553, 2019 | 25 | 2019 |
Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles RB Hamed, J Mecinović, C Ducho, TDW Claridge, CJ Schofield Chemical communications 46 (9), 1413-1415, 2010 | 22 | 2010 |
Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 M Mantri, CJ Webby, ND Loik, RB Hamed, ML Nielsen, MA McDonough, ... MedChemComm 3 (1), 80-85, 2012 | 20 | 2012 |
Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles TJ Smart, RB Hamed, TDW Claridge, CJ Schofield Bioorganic Chemistry 94, 103386, 2020 | 15 | 2020 |
Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase RB Hamed, L Henry, JR Gomez-Castellanos, A Asghar, J Brem, ... Organic & biomolecular chemistry 11 (47), 8191-8196, 2013 | 15 | 2013 |