| Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J Le Quesne, ... Cell death & disease 6 (3), e1672-e1672, 2015 | 358 | 2015 |
| Mutations in a translation initiation factor identify the target of a memory-enhancing compound Y Sekine, A Zyryanova, A Crespillo-Casado, PM Fischer, HP Harding, ... Science 348 (6238), 1027-1030, 2015 | 231 | 2015 |
| Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B AF Zyryanova, F Weis, A Faille, AA Alard, A Crespillo-Casado, Y Sekine, ... Science 359 (6383), 1533-1536, 2018 | 194 | 2018 |
| The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases Y Sekine, K Takeda, H Ichijo Current molecular medicine 6 (1), 87-97, 2006 | 185 | 2006 |
| Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1 K Takeda, Y Komuro, T Hayakawa, H Oguchi, Y Ishida, S Murakami, ... Proceedings of the National Academy of Sciences 106 (30), 12301-12305, 2009 | 159 | 2009 |
| The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses K Mosallanejad, Y Sekine, S Ishikura-Kinoshita, K Kumagai, T Nagano, ... Science signaling 7 (323), ra40-ra40, 2014 | 93 | 2014 |
| The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5 Y Sekine, R Hatanaka, T Watanabe, N Sono, S Iemura, T Natsume, ... Molecular cell 48 (5), 692-704, 2012 | 90 | 2012 |
| Apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis T Watanabe, S Sekine, I Naguro, Y Sekine, H Ichijo Journal of Biological Chemistry 290 (17), 10791-10803, 2015 | 57 | 2015 |
| p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors Y Sekine, S Takagahara, R Hatanaka, T Watanabe, H Oguchi, T Noguchi, ... Journal of cell science 124 (17), 3006-3016, 2011 | 41 | 2011 |
| Sequential CRISPR-based screens identify LITAF and CDIP1 as the Bacillus cereus hemolysin BL toxin host receptors J Liu, Z Zuo, I Sastalla, C Liu, JY Jang, Y Sekine, Y Li, M Pirooznia, ... Cell host & microbe 28 (3), 402-410. e5, 2020 | 30 | 2020 |
| Paradoxical sensitivity to an integrated stress response blocking mutation in vanishing white matter cells Y Sekine, A Zyryanova, A Crespillo-Casado, N Amin-Wetzel, HP Harding, ... PloS one 11 (11), e0166278, 2016 | 30 | 2016 |
| A mitochondrial iron-responsive pathway regulated by DELE1 Y Sekine, R Houston, EM Eckl, E Fessler, DP Narendra, LT Jae, S Sekine Molecular cell 83 (12), 2059-2076. e6, 2023 | 26 | 2023 |
| Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster Y Ishida, Y Sekine, H Oguchi, T Chihara, M Miura, H Ichijo, K Takeda PloS one 7 (2), e30265, 2012 | 24 | 2012 |
| Signaling pathways in invertebrate immune and stress response R Hatanaka, Y Sekine, T Hayakawa, K Takeda, H Ichijo Invertebrate Survival Journal 6 (1), 32-43, 2009 | 24 | 2009 |
| Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses R Houston, S Sekine, MJ Calderon, F Seifuddin, G Wang, H Kawagishi, ... PLoS biology 18 (11), e3000981, 2020 | 23 | 2020 |
| Cellular metabolic stress responses via organelles Y Sekine, R Houston, S Sekine Experimental cell research 400 (1), 112515, 2021 | 16 | 2021 |
| Hyperlipidaemia and IFNgamma/TNFalpha synergism are associated with cholesterol crystal formation in endothelial cells partly through modulation of lysosomal pH and cholesterol … Y Baumer, AK Dey, CA Gutierrez-Huerta, NO Khalil, Y Sekine, GE Sanda, ... EBioMedicine 59, 2020 | 14 | 2020 |
| The coupling of translational control and stress responses R Houston, S Sekine, Y Sekine The journal of biochemistry 168 (2), 93-102, 2020 | 14 | 2020 |
| Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis 6: e1672 M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J Le Quesne, ... | 14 | 2015 |
| Modulation of lysosomal function as a therapeutic approach for coronaviral infections Y Liu, T Lear, M Larsen, B Lin, Q Cao, I Alfaras, J Kennerdell, L Salminen, ... Research Square, 2021 | 12 | 2021 |
