Mitophagy protects β cells from inflammatory damage in diabetes V Sidarala, GL Pearson, VS Parekh, B Thompson, L Christen, ... JCI insight 5 (24), 2020 | 79 | 2020 |
The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: lessons learned from the pancreatic β-cell V Sidarala, A Kowluru Recent patents on endocrine, metabolic & immune drug discovery 10 (2), 76-84, 2016 | 68 | 2016 |
Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: evidence for a requisite role of Ras-related C3 botulinum … V Sidarala, R Veluthakal, K Syeda, C Vlaar, P Newsholme, A Kowluru Biochemical pharmacology 95 (4), 301-310, 2015 | 44 | 2015 |
VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells R Veluthakal, R Tunduguru, DK Arora, V Sidarala, K Syeda, CP Vlaar, ... Diabetologia 58, 2573-2581, 2015 | 41 | 2015 |
Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis V Sidarala, J Zhu, E Levi-D’Ancona, GL Pearson, EC Reck, EM Walker, ... Nature communications 13 (1), 2340, 2022 | 40 | 2022 |
NSC23766, a known inhibitor of Tiam1-Rac1 signaling module, prevents the onset of type 1 diabetes in the NOD mouse model R Veluthakal, V Sidarala, A Kowluru Cellular Physiology and Biochemistry 39 (2), 760-767, 2016 | 39 | 2016 |
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells S Khadija, R Veluthakal, V Sidarala, A Kowluru Apoptosis 19, 1691-1701, 2014 | 26 | 2014 |
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells V Sidarala, A Kowluru Apoptosis 22, 597-607, 2017 | 25 | 2017 |
EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells V Sidarala, R Veluthakal, K Syeda, A Kowluru Cellular signalling 27 (6), 1159-1167, 2015 | 20 | 2015 |
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing GA Rutter, V Sidarala, BA Kaufman, SA Soleimanpour Biochemical Journal 480 (11), 773-789, 2023 | 12 | 2023 |
Clarifying the function of genes at the chromosome 16p13 locus in type 1 diabetes: CLEC16A and DEXI MA Gingerich, V Sidarala, SA Soleimanpour Genes & Immunity 21 (2), 79-82, 2020 | 11 | 2020 |
β-Cell Cre Expression and Reduced Ins1 Gene Dosage Protect Mice From Type 1 Diabetes S Skovsø, P Overby, J Memar-Zadeh, JTC Lee, JCC Yang, I Shanina, ... Endocrinology 163 (11), bqac144, 2022 | 7 | 2022 |
Mitophagy protects beta cells from inflammatory damage in diabetes. JCI Insight. 2020; 5: e141138 V Sidarala, GL Pearson, VS Parekh, B Thompson, L Christen, ... | 7 | |
An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy MA Gingerich, X Liu, B Chai, GL Pearson, MP Vincent, T Stromer, J Zhu, ... Autophagy 19 (2), 525-543, 2023 | 6 | 2023 |
Reciprocal regulatory balance within the CLEC16A–RNF41 mitophagy complex depends on an intrinsically disordered protein region MA Gingerich, J Zhu, B Chai, MP Vincent, N Xie, V Sidarala, NA Kotov, ... Journal of Biological Chemistry 299 (4), 2023 | 4 | 2023 |
Mitofusin 1 and 2 regulation of mtDNA content is a critical determinant of glucose homeostasis V Sidarala, J Zhu, G Pearson, E Reck, B Kaufman, S Soleimanpour | 3* | 2021 |
Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing BE Fashemi, L van Biljon, J Rodriguez, O Graham, M Mullen, D Khabele JoVE (Journal of Visualized Experiments), e65068, 2023 | 2 | 2023 |
Mechanisms of pancreatic beta cell dysfunction in diabetes V Sidarala Wayne State University, 2016 | 2 | 2016 |
Complementary Approaches to Interrogate Mitophagy Flux in Pancreatic β-Cells E Levi-D’Ancona, V Sidarala, SA Soleimanpour Journal of visualized experiments: JoVE, 2023 | 1 | 2023 |
287-OR: Traf6 Directs a Noncanonical Role for Innate Immune Signaling in Pancreatic ß-Cells E LEVI D ANCONA, JIE ZHU, EM WALKER, V SIDARALA, ... Diabetes 73 (Supplement_1), 2024 | | 2024 |