Aging of blood can be tracked by DNA methylation changes at just three CpG sites CI Weidner, Q Lin, CM Koch, L Eisele, F Beier, P Ziegler, DO Bauerschlag, ... Genome biology 15, 1-12, 2014 | 901 | 2014 |
Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation A Reinisch, N Etchart, D Thomas, NA Hofmann, M Fruehwirth, S Sinha, ... Blood, the Journal of the American Society of Hematology 125 (2), 249-260, 2015 | 248 | 2015 |
Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling M Hohwieler, A Illing, PC Hermann, T Mayer, M Stockmann, L Perkhofer, ... Gut 66 (3), 473-486, 2017 | 222 | 2017 |
Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks A Schellenberg, Q Lin, H Schüler, CM Koch, S Joussen, B Denecke, ... Aging (Albany NY) 3 (9), 873, 2011 | 211 | 2011 |
DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy Q Lin, CI Weidner, IG Costa, RE Marioni, MRP Ferreira, IJ Deary, ... Aging (Albany NY) 8 (2), 394, 2016 | 189 | 2016 |
The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation M Kalwa, S Hänzelmann, S Otto, CC Kuo, J Franzen, S Joussen, ... Nucleic acids research 44 (22), 10631-10643, 2016 | 161 | 2016 |
Pluripotent stem cells escape from senescence-associated DNA methylation changes CM Koch, K Reck, K Shao, Q Lin, S Joussen, P Ziegler, G Walenda, ... Genome research 23 (2), 248-259, 2013 | 153 | 2013 |
Specific age-associated DNA methylation changes in human dermal fibroblasts CM Koch, CV Suschek, Q Lin, S Bork, M Goergens, S Joussen, N Pallua, ... PloS one 6 (2), e16679, 2011 | 151 | 2011 |
Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition R Russell, L Perkhofer, S Liebau, Q Lin, A Lechel, FM Feld, E Hessmann, ... Nature communications 6 (1), 7677, 2015 | 149 | 2015 |
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells A Kleger, T Seufferlein, D Malan, M Tischendorf, A Storch, A Wolheim, ... Circulation 122 (18), 1823-1836, 2010 | 142 | 2010 |
Parthenogenetic stem cells for tissue-engineered heart repair M Didié, P Christalla, M Rubart, V Muppala, S Döker, B Unsöld, ... The Journal of clinical investigation 123 (3), 1285-1298, 2013 | 127 | 2013 |
Epigenetic aging signatures are coherently modified in cancer Q Lin, W Wagner PLoS genetics 11 (6), e1005334, 2015 | 125 | 2015 |
Monitoring of cellular senescence by DNA‐methylation at specific CpG sites CM Koch, S Joussen, A Schellenberg, Q Lin, M Zenke, W Wagner Aging cell 11 (2), 366-369, 2012 | 118 | 2012 |
ATM deficiency generating genomic instability sensitizes pancreatic ductal adenocarcinoma cells to therapy-induced DNA damage L Perkhofer, A Schmitt, MC Romero Carrasco, M Ihle, S Hampp, ... Cancer research 77 (20), 5576-5590, 2017 | 104 | 2017 |
Human adult germline stem cells in question K Ko, MJ Araúzo-Bravo, N Tapia, J Kim, Q Lin, C Bernemann, DW Han, ... Nature 465 (7301), E1-E1, 2010 | 99 | 2010 |
TBX3 directs cell-fate decision toward mesendoderm CE Weidgang, R Russell, PR Tata, SJ Kühl, A Illing, M Müller, Q Lin, ... Stem cell reports 1 (3), 248-265, 2013 | 95 | 2013 |
Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells A Schellenberg, S Joussen, K Moser, N Hampe, N Hersch, H Hemeda, ... Biomaterials 35 (24), 6351-6358, 2014 | 78 | 2014 |
Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells L Linta, M Stockmann, KN Kleinhans, A Böckers, A Storch, H Zaehres, ... Stem cells and development 21 (6), 965-976, 2012 | 76 | 2012 |
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia E Jost, Q Lin, CI Weidner, S Wilop, M Hoffmann, T Walenda, ... Leukemia 28 (6), 1227-1234, 2014 | 72 | 2014 |
Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles K Shao, C Koch, MK Gupta, Q Lin, M Lenz, S Laufs, B Denecke, ... Molecular Therapy 21 (1), 240-250, 2013 | 70 | 2013 |