| High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations K Das, JD Bauman, AD Clark Jr, YV Frenkel, PJ Lewi, AJ Shatkin, ... Proceedings of the National Academy of Sciences 105 (5), 1466-1471, 2008 | 404 | 2008 |
| HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism K Das, SE Martinez, JD Bauman, E Arnold Nature structural & molecular biology 19 (2), 253-259, 2012 | 198 | 2012 |
| Structure of HIV-1 reverse transcriptase with the inhibitor β-thujaplicinol bound at the RNase H active site DM Himmel, KA Maegley, TA Pauly, JD Bauman, K Das, C Dharia, ... Structure 17 (12), 1625-1635, 2009 | 162 | 2009 |
| Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase C Fang, JD Bauman, K Das, A Remorino, E Arnold, RM Hochstrasser Proceedings of the National Academy of Sciences 105 (5), 1472-1477, 2008 | 157 | 2008 |
| Structural basis of HIV-1 resistance to AZT by excision X Tu, K Das, Q Han, JD Bauman, AD Clark Jr, X Hou, YV Frenkel, ... Nature structural & molecular biology 17 (10), 1202-1209, 2010 | 144 | 2010 |
| Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase DG Kuroda, JD Bauman, JR Challa, D Patel, T Troxler, K Das, E Arnold, ... Nature chemistry 5 (3), 174-181, 2013 | 109 | 2013 |
| Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design JD Bauman, K Das, WC Ho, M Baweja, DM Himmel, AD Clark, DA Oren, ... Nucleic acids research 36 (15), 5083-5092, 2008 | 106 | 2008 |
| Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery D Patel, JD Bauman, E Arnold Progress in biophysics and molecular biology 116 (2-3), 92-100, 2014 | 100 | 2014 |
| Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors JD Bauman, D Patel, SF Baker, RSK Vijayan, A Xiang, AK Parhi, ... ACS chemical biology 8 (11), 2501-2508, 2013 | 96 | 2013 |
| Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening JD Bauman, D Patel, C Dharia, MW Fromer, S Ahmed, Y Frenkel, ... Journal of medicinal chemistry 56 (7), 2738-2746, 2013 | 92 | 2013 |
| Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H S Chung, DM Himmel, JK Jiang, K Wojtak, JD Bauman, JW Rausch, ... Journal of medicinal chemistry 54 (13), 4462-4473, 2011 | 91 | 2011 |
| Pokeweed antiviral protein binds to the cap structure of eukaryotic mRNA and depurinates the mRNA downstream of the cap KA Hudak, JD Bauman, NE Tumer Rna 8 (9), 1148-1159, 2002 | 84 | 2002 |
| Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic … K Das, JD Bauman, AS Rim, C Dharia, AD Clark Jr, MJ Camarasa, ... Journal of medicinal chemistry 54 (8), 2727-2737, 2011 | 82 | 2011 |
| Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease HY Sagong, JD Bauman, D Patel, K Das, E Arnold, EJ LaVoie Journal of medicinal chemistry 57 (19), 8086-8098, 2014 | 65 | 2014 |
| 3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease HY Sagong, A Parhi, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ... ACS medicinal chemistry letters 4 (6), 547-550, 2013 | 64 | 2013 |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme C Chu, K Das, JR Tyminski, JD Bauman, R Guan, W Qiu, GT Montelione, ... Proceedings of the National Academy of Sciences 108 (25), 10104-10108, 2011 | 53 | 2011 |
| A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants BC Johnson, GT Pauly, G Rai, D Patel, JD Bauman, HL Baker, K Das, ... Retrovirology 9, 1-11, 2012 | 48 | 2012 |
| Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies AK Felts, K LaBarge, JD Bauman, DV Patel, DM Himmel, E Arnold, ... Journal of chemical information and modeling 51 (8), 1986-1998, 2011 | 44 | 2011 |
| Phenyl substituted 3-hydroxypyridin-2 (1H)-ones: inhibitors of influenza A endonuclease AK Parhi, A Xiang, JD Bauman, D Patel, RSK Vijayan, K Das, E Arnold, ... Bioorganic & medicinal chemistry 21 (21), 6435-6446, 2013 | 42 | 2013 |
| Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility M Bollini, KM Frey, JA Cisneros, KA Spasov, K Das, JD Bauman, E Arnold, ... Bioorganic & medicinal chemistry letters 23 (18), 5209-5212, 2013 | 39 | 2013 |
