High interstitial fluid pressure—an obstacle in cancer therapy CH Heldin, K Rubin, K Pietras, A Östman Nature Reviews Cancer 4 (10), 806-813, 2004 | 2412 | 2004 |
Protein detection using proximity-dependent DNA ligation assays S Fredriksson, M Gullberg, J Jarvius, C Olsson, K Pietras, ... Nature biotechnology 20 (5), 473-477, 2002 | 1688 | 2002 |
Hallmarks of cancer: interactions with the tumor stroma K Pietras, A Östman Experimental cell research 316 (8), 1324-1331, 2010 | 1492 | 2010 |
Signal transduction via platelet-derived growth factor receptors CH Heldin, A Östman, L Rönnstrand Biochimica et Biophysica Acta (BBA)-reviews on cancer 1378 (1), F79-F113, 1998 | 1086 | 1998 |
PDGF-C is a new protease-activated ligand for the PDGF α-receptor X Li, A Pontén, K Aase, L Karlsson, A Abramsson, M Uutela, G Bäckström, ... Nature cell biology 2 (5), 302-309, 2000 | 837 | 2000 |
Protein-tyrosine phosphatases and cancer A Östman, C Hellberg, FD Böhmer Nature Reviews Cancer 6 (4), 307-320, 2006 | 828 | 2006 |
PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor E Bergsten, M Uutela, X Li, K Pietras, A Östman, CH Heldin, K Alitalo, ... Nature cell biology 3 (5), 512-516, 2001 | 782 | 2001 |
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall P Lindblom, H Gerhardt, S Liebner, A Abramsson, M Enge, M Hellström, ... Genes & development 17 (15), 1835-1840, 2003 | 759 | 2003 |
Cancer-associated fibroblasts and tumor growth–bystanders turning into key players A Östman, M Augsten Current opinion in genetics & development 19 (1), 67-73, 2009 | 673 | 2009 |
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. CH Heldin, G Bäckström, A Ostman, A Hammacher, L Rönnstrand, ... The EMBO journal 7 (5), 1387-1393, 1988 | 621 | 1988 |
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors K Pietras, A Ostman, M Sjöquist, E Buchdunger, RK Reed, CH Heldin, ... Cancer research 61 (7), 2929-2934, 2001 | 578 | 2001 |
PDGF receptors as cancer drug targets K Pietras, T Sjöblom, K Rubin, CH Heldin, A Östman Cancer cell 3 (5), 439-443, 2003 | 577 | 2003 |
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy K Pietras, K Rubin, T Sjöblom, E Buchdunger, M Sjöquist, CH Heldin, ... Cancer research 62 (19), 5476-5484, 2002 | 560 | 2002 |
Inhibitory DNA ligands to platelet-derived growth factor B-chain LS Green, D Jellinek, R Jenison, A Östman, CH Heldin, N Janjic Biochemistry 35 (45), 14413-14424, 1996 | 555 | 1996 |
Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases A Östman, FD Böhmer Trends in cell biology 11 (6), 258-266, 2001 | 450 | 2001 |
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules L Claesson-Welsh, A Eriksson, A Morén, L Severinsson, B Ek, A Ostman, ... Molecular and cellular biology 8 (8), 3476-3486, 1988 | 427 | 1988 |
PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma A Östman Cytokine & growth factor reviews 15 (4), 275-286, 2004 | 412 | 2004 |
A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain. A Hammacher, U Hellman, A Johnsson, A Ostman, K Gunnarsson, ... Journal of Biological Chemistry 263 (31), 16493-16498, 1988 | 400 | 1988 |
The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to … A Shimizu, KP O’Brien, T Sjöblom, K Pietras, E Buchdunger, VP Collins, ... Cancer research 59 (15), 3719-3723, 1999 | 350 | 1999 |
PDGF and vessel maturation C Hellberg, A Östman, CH Heldin Angiogenesis inhibition, 103-114, 2010 | 344 | 2010 |