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| Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ... Nature genetics 49 (12), 1779-1784, 2017 | 1572 | 2017 |
| Patient-derived xenografts undergo mouse-specific tumor evolution U Ben-David, G Ha, YY Tseng, NF Greenwald, C Oh, J Shih, ... Nature genetics 49 (11), 1567-1575, 2017 | 706 | 2017 |
| Discovering the anticancer potential of non-oncology drugs by systematic viability profiling SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ... Nature cancer 1 (2), 235-248, 2020 | 565 | 2020 |
| Mutational processes shape the landscape of TP53 mutations in human cancer AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ... Nature genetics 50 (10), 1381-1387, 2018 | 406 | 2018 |
| Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ... Nature communications 9 (1), 4610, 2018 | 337 | 2018 |
| WRN helicase is a synthetic lethal target in microsatellite unstable cancers EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ... Nature 568 (7753), 551-556, 2019 | 287 | 2019 |
| Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer S Raghavan, PS Winter, AW Navia, HL Williams, A DenAdel, KE Lowder, ... Cell 184 (25), 6119-6137. e26, 2021 | 271 | 2021 |
| Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity GS Kinker, AC Greenwald, R Tal, Z Orlova, MS Cuoco, JM McFarland, ... Nature genetics 52 (11), 1208-1218, 2020 | 270 | 2020 |
| Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition GS Wong, J Zhou, JB Liu, Z Wu, X Xu, T Li, D Xu, SE Schumacher, ... Nature medicine 24 (7), 968-977, 2018 | 240 | 2018 |
| Integrated cross-study datasets of genetic dependencies in cancer C Pacini, JM Dempster, I Boyle, E Gonçalves, H Najgebauer, E Karakoc, ... Nature communications 12 (1), 1661, 2021 | 193 | 2021 |
| Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects JM Dempster, I Boyle, F Vazquez, DE Root, JS Boehm, WC Hahn, ... Genome biology 22, 1-23, 2021 | 184 | 2021 |
| Inferring nonlinear neuronal computation based on physiologically plausible inputs JM McFarland, Y Cui, DA Butts PLoS computational biology 9 (7), e1003143, 2013 | 173 | 2013 |
| Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition Y Cohen-Sharir, JM McFarland, M Abdusamad, C Marquis, SV Bernhard, ... Nature 590 (7846), 486-491, 2021 | 165 | 2021 |
| Spontaneous persistent activity in entorhinal cortex modulates cortico-hippocampal interaction in vivo TTG Hahn, JM McFarland, S Berberich, B Sakmann, MR Mehta Nature neuroscience 15 (11), 1531-1538, 2012 | 152 | 2012 |
| Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action JM McFarland, BR Paolella, A Warren, K Geiger-Schuller, T Shibue, ... Nature communications 11 (1), 4296, 2020 | 111 | 2020 |
| Speed controls the amplitude and timing of the hippocampal gamma rhythm Z Chen, E Resnik, JM McFarland, B Sakmann, MR Mehta PloS one 6 (6), e21408, 2011 | 110 | 2011 |
| A first-generation pediatric cancer dependency map NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, ... Nature genetics 53 (4), 529-538, 2021 | 99 | 2021 |
| Global computational alignment of tumor and cell line transcriptional profiles A Warren, Y Chen, A Jones, T Shibue, WC Hahn, JS Boehm, F Vazquez, ... Nature communications 12 (1), 22, 2021 | 92 | 2021 |
| Saccadic modulation of stimulus processing in primary visual cortex JM McFarland, AG Bondy, RC Saunders, BG Cumming, DA Butts Nature communications 6 (1), 8110, 2015 | 76 | 2015 |
