A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses JM Steichen, YC Lin, C Havenar-Daughton, S Pecetta, G Ozorowski, ... Science 366 (6470), eaax4380, 2019 | 210 | 2019 |
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization YC Lin, DY Huang, JS Wang, YL Lin, SL Hsieh, KC Huang, WW Lin Journal of Leucocyte Biology 97 (5), 825-835, 2015 | 155 | 2015 |
The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3 YC Lin, DY Huang, CL Chu, YL Lin, WW Lin Science signaling 6 (289), ra71-ra71, 2013 | 109 | 2013 |
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses JMJ Tas, JH Koo, YC Lin, Z Xie, JM Steichen, AM Jackson, BM Hauser, ... Immunity 55 (10), 1856-1871. e6, 2022 | 94 | 2022 |
Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway YC Lin, DY Huang, CL Chu, WW Lin Molecular immunology 47 (7-8), 1569-1578, 2010 | 84 | 2010 |
Syk mediates IL− 17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6 NL Wu, DY Huang, HN Tsou, YC Lin, WW Lin Journal of Investigative Dermatology 135 (2), 490-498, 2015 | 74 | 2015 |
HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation YH Liao, YC Lin, ST Tsao, YC Lin, AJ Yang, CT Huang, KC Huang, ... Journal of leukocyte biology 93 (2), 289-299, 2013 | 57 | 2013 |
Enhanced phosphocholine metabolism is essential for terminal erythropoiesis NJ Huang, YC Lin, CY Lin, N Pishesha, CA Lewis, E Freinkman, ... Blood, The Journal of the American Society of Hematology 131 (26), 2955-2966, 2018 | 50 | 2018 |
Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors X Wang, R Ray, S Kratochvil, E Melzi, YC Lin, S Giguere, L Xu, J Warner, ... The EMBO Journal 40 (2), e105926, 2021 | 39 | 2021 |
One‐step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock‐in mice YC Lin, S Pecetta, JM Steichen, S Kratochvil, E Melzi, J Arnold, ... The EMBO journal 37 (18), e99243, 2018 | 37 | 2018 |
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice E Melzi, JR Willis, KM Ma, YC Lin, S Kratochvil, ZT Berndsen, EA Landais, ... Immunity 55 (11), 2168-2186. e6, 2022 | 29 | 2022 |
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies S Kratochvil, CH Shen, YC Lin, K Xu, U Nair, LDS Pereira, P Tripathi, ... Immunity 54 (12), 2859-2876. e7, 2021 | 26 | 2021 |
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science 366: eaax4380 JM Steichen, YC Lin, C Havenar-Daughton, S Pecetta, G Ozorowski, ... | 14 | 2019 |
Vaccination induces broadly neutralizing antibody precursors to HIV gp41 T Schiffner, I Phung, R Ray, A Irimia, M Tian, O Swanson, JH Lee, ... Nature immunology 25 (6), 1073-1082, 2024 | 12 | 2024 |
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies Z Xie, YC Lin, JM Steichen, G Ozorowski, S Kratochvil, R Ray, JL Torres, ... Science 384 (6697), eadk0582, 2024 | 10 | 2024 |
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors R Ray, T Schiffner, X Wang, Y Yan, K Rantalainen, CCD Lee, S Parikh, ... Nature Immunology, 1-14, 2024 | 3 | 2024 |
Engineering better bnAbs PN Kelly Science 366 (6470), 1209-1211, 2019 | | 2019 |