The role of toxin A and toxin B in Clostridium difficile infection SA Kuehne, ST Cartman, JT Heap, ML Kelly, A Cockayne, NP Minton Nature 467 (7316), 711, 2010 | 953 | 2010 |
The ClosTron: a universal gene knock-out system for the genus Clostridium JT Heap, OJ Pennington, ST Cartman, GP Carter, NP Minton Journal of microbiological methods 70 (3), 452-464, 2007 | 832 | 2007 |
A modular system for Clostridium shuttle plasmids JT Heap, OJ Pennington, ST Cartman, NP Minton Journal of microbiological methods 78 (1), 79-85, 2009 | 551 | 2009 |
The ClosTron: mutagenesis in Clostridium refined and streamlined JT Heap, SA Kuehne, M Ehsaan, ST Cartman, CM Cooksley, JC Scott, ... Journal of microbiological methods 80 (1), 49-55, 2010 | 511 | 2010 |
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production ST Cartman, ML Kelly, D Heeg, JT Heap, NP Minton Applied and environmental microbiology 78 (13), 4683-4690, 2012 | 291 | 2012 |
Review of NAD (P) H-dependent oxidoreductases: Properties, engineering and application L Sellés, CL Kelly, PM Mordaka, JT Heap Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2017 | 281* | 2017 |
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker JT Heap, M Ehsaan, CM Cooksley, YK Ng, ST Cartman, K Winzer, ... Nucleic acids research 40 (8), e59-e59, 2012 | 248 | 2012 |
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum E Steiner, AE Dago, DI Young, JT Heap, NP Minton, JA Hoch, M Young Molecular microbiology 80 (3), 641-654, 2011 | 168 | 2011 |
The emergence of ‘hypervirulence’in Clostridium difficile ST Cartman, JT Heap, SA Kuehne, A Cockayne, NP Minton International Journal of Medical Microbiology 300 (6), 387-395, 2010 | 163 | 2010 |
SleC is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate DA Burns, JT Heap, NP Minton Journal of bacteriology 192 (3), 657-664, 2010 | 162 | 2010 |
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo JT Heap, J Theys, M Ehsaan, AM Kubiak, L Dubois, K Paesmans, ... Oncotarget 5 (7), 1761-1769, 2014 | 89 | 2014 |
The diverse sporulation characteristics of Clostridium difficile clinical isolates are not associated with type DA Burns, JT Heap, NP Minton Anaerobe 16 (6), 618-622, 2010 | 88 | 2010 |
Clostridium difficile spore germination: an update DA Burns, JT Heap, NP Minton Research in microbiology 161 (9), 730-734, 2010 | 78 | 2010 |
Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824 M Ehsaan, W Kuit, Y Zhang, ST Cartman, JT Heap, K Winzer, NP Minton Biotechnology for biofuels 9 (1), 1-20, 2016 | 75 | 2016 |
Synthetic negative feedback circuits using engineered small RNAs CL Kelly, AWK Harris, H Steel, EJ Hancock, JT Heap, ... Nucleic acids research 46 (18), 9875-9889, 2018 | 70 | 2018 |
A rhamnose-inducible system for precise and temporal control of gene expression in cyanobacteria CL Kelly, GM Taylor, A Hitchcock, A Torres-Méndez, JT Heap ACS synthetic biology 7 (4), 1056-1066, 2018 | 68 | 2018 |
ClosTron-targeted mutagenesis JT Heap, ST Cartman, SA Kuehne, C Cooksley, NP Minton Clostridium difficile: Methods and Protocols, 165-182, 2010 | 61 | 2010 |
ClosTron-targeted mutagenesis JT Heap, ST Cartman, SA Kuehne, C Cooksley, NP Minton Clostridium difficile: Methods and Protocols, 165-182, 2010 | 61 | 2010 |
Start-Stop Assembly: a functionally scarless DNA assembly system optimized for metabolic engineering GM Taylor, PM Mordaka, JT Heap Nucleic acids research 47 (3), e17-e17, 2019 | 59 | 2019 |
Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824 K Kovács, BJ Willson, K Schwarz, JT Heap, A Jackson, DN Bolam, ... Biotechnology for biofuels 6, 1-14, 2013 | 56 | 2013 |