| Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease K Midwood, S Sacre, AM Piccinini, J Inglis, A Trebaul, E Chan, S Drexler, ... Nature medicine 15 (7), 774-780, 2009 | 795 | 2009 |
| Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal S Salzano, P Checconi, EM Hanschmann, CH Lillig, LD Bowler, P Chan, ... Proceedings of the National Academy of Sciences 111 (33), 12157-12162, 2014 | 389 | 2014 |
| Distinct pathways of LPS-induced NF-κB activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP E Andreakos, SM Sacre, C Smith, A Lundberg, S Kiriakidis, T Stonehouse, ... Blood 103 (6), 2229-2237, 2004 | 285 | 2004 |
| The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis SM Sacre, E Andreakos, S Kiriakidis, P Amjadi, A Lundberg, G Giddins, ... The American journal of pathology 170 (2), 518-525, 2007 | 238 | 2007 |
| Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll‐like receptors S Sacre, M Medghalchi, B Gregory, F Brennan, R Williams Arthritis & Rheumatism 62 (3), 683-693, 2010 | 208 | 2010 |
| Key differences in TLR3/poly I: C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems AM Lundberg, SK Drexler, C Monaco, LM Williams, SM Sacre, ... Blood, The Journal of the American Society of Hematology 110 (9), 3245-3252, 2007 | 192 | 2007 |
| Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells AK Stannard, DR Riddell, SM Sacre, AD Tagalakis, C Langer, ... Journal of Biological Chemistry 276 (49), 46011-46016, 2001 | 132 | 2001 |
| Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures SM Sacre, A Lo, B Gregory, RE Simmonds, L Williams, M Feldmann, ... The Journal of Immunology 181 (11), 8002-8009, 2008 | 123 | 2008 |
| Is NF-κB a useful therapeutic target in rheumatoid arthritis? M Feldmann, E Andreakos, C Smith, J Bondeson, S Yoshimura, ... Annals of the rheumatic diseases 61 (suppl 2), ii13-ii18, 2002 | 113 | 2002 |
| Advances in Toll-like receptor biology: Modes of activation by diverse stimuli CE Bryant, NJ Gay, S Heymans, S Sacre, L Schaefer, KS Midwood Critical reviews in biochemistry and molecular biology 50 (5), 359-379, 2015 | 109 | 2015 |
| Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells SM Sacre, AK Stannard, JS Owen FEBS letters 540 (1-3), 181-187, 2003 | 96 | 2003 |
| Emerging role of endosomal toll-like receptors in rheumatoid arthritis R Thwaites, G Chamberlain, S Sacre Frontiers in immunology 5, 1, 2014 | 91 | 2014 |
| The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis E Andreakos, S Sacre, BM Foxwell, M Feldmann Front Biosci 10, 2478-2488, 2005 | 82 | 2005 |
| Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease LM Mullen, G Chamberlain, S Sacre Arthritis research & therapy 17, 1-10, 2015 | 69 | 2015 |
| Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance S Alzabin, P Kong, M Medghalchi, A Palfreeman, R Williams, S Sacre Arthritis research & therapy 14, 1-11, 2012 | 62 | 2012 |
| Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-κB activation and cytokine production in primary human cells: TRAM is an adaptor for … SM Sacre, A Lundberg, E Andreakos, C Taylor, M Feldmann, BM Foxwell The Journal of Immunology 178 (4), 2148-2154, 2007 | 50 | 2007 |
| Targeting Toll-like receptors in autoimmunity KS Midwood, AM Piccinini, S Sacre Current drug targets 10 (11), 1139-1155, 2009 | 47 | 2009 |
| A feasibility study exploring the role of pre-operative assessment when examining the mechanism of ‘chemo-brain’in breast cancer patients V Jenkins, R Thwaites, M Cercignani, S Sacre, N Harrison, ... Springerplus 5, 1-11, 2016 | 39 | 2016 |
| Intracellular localization of endothelial cell annexins is differentially regulated by oxidative stress SM Sacre, SE Moss Experimental cell research 274 (2), 254-263, 2002 | 39 | 2002 |
| Precipitation of soluble uric acid is necessary for in vitro activation of the NLRP3 inflammasome in primary human monocytes BM Alberts, JS Barber, SM Sacre, KA Davies, P Ghezzi, LM Mullen The Journal of rheumatology 46 (9), 1141-1150, 2019 | 36 | 2019 |
