Isocombretastatins A versus Combretastatins A: The Forgotten isoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent S Messaoudi, B Tréguier, A Hamze, O Provot, JF Peyrat, JR De Losada, ... Journal of medicinal chemistry 52 (14), 4538-4542, 2009 | 268 | 2009 |
Sulfinate derivatives: dual and versatile partners in organic synthesis J Aziz, S Messaoudi, M Alami, A Hamze Organic & Biomolecular Chemistry 12 (48), 9743-9759, 2014 | 267 | 2014 |
Discovery of isoerianin analogues as promising anticancer agents S Messaoudi, A Hamze, O Provot, B Tréguier, J Rodrigo De Losada, ... ChemMedChem 6 (3), 488-497, 2011 | 142 | 2011 |
Pd-Catalyzed Reaction of Sterically Hindered Hydrazones with Aryl Halides: Synthesis of Tetra-Substituted Olefins Related to iso-Combretastatin A4 E Brachet, A Hamze, JF Peyrat, JD Brion, M Alami Organic Letters 12 (18), 4042-4045, 2010 | 121 | 2010 |
Synthesis and antitumor activity of benzils related to combretastatin A-4 C Mousset, A Giraud, O Provot, A Hamze, J Bignon, JM Liu, S Thoret, ... Bioorganic & Medicinal Chemistry Letters 18 (11), 3266-3271, 2008 | 115 | 2008 |
DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five-or six-membered heterocycles C Mousset, O Provot, A Hamze, J Bignon, JD Brion, M Alami Tetrahedron 64 (19), 4287-4294, 2008 | 110 | 2008 |
p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles M Jacubert, O Provot, JF Peyrat, A Hamze, JD Brion, M Alami Tetrahedron 66 (21), 3775-3787, 2010 | 99 | 2010 |
Expeditious synthesis of 1, 1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates B Tréguier, A Hamze, O Provot, JD Brion, M Alami Tetrahedron Letters 50 (47), 6549-6552, 2009 | 95 | 2009 |
Mono-and bis-thiazolium salts have potent antimalarial activity A Hamzé, E Rubi, P Arnal, M Boisbrun, C Carcel, X Salom-Roig, ... Journal of medicinal chemistry 48 (10), 3639-3643, 2005 | 93 | 2005 |
Synthesis, Biological Evaluation of 1, 1‐Diarylethylenes as a Novel Class of Antimitotic Agents A Hamze, A Giraud, S Messaoudi, O Provot, JF Peyrat, J Bignon, JM Liu, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (11), 1912-1924, 2009 | 92 | 2009 |
Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β3- and α-Amino Acids from Fmoc-Protected Aspartic Acid A Hamze, JF Hernandez, P Fulcrand, J Martinez The Journal of Organic Chemistry 68 (19), 7316-7321, 2003 | 89 | 2003 |
Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines A Hamze, B Tréguier, JD Brion, M Alami Organic & Biomolecular Chemistry 9 (18), 6200-6204, 2011 | 88 | 2011 |
Stereoretentive Palladium‐Catalyzed Arylation, Alkenylation, and Alkynylation of 1‐Thiosugars and Thiols Using Aminobiphenyl Palladacycle Precatalyst at Room Temperature A Bruneau, M Roche, A Hamze, JD Brion, M Alami, S Messaoudi Chemistry–A European Journal 21 (23), 8375-8379, 2015 | 85 | 2015 |
Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy A Maksimenko, M Alami, F Zouhiri, JD Brion, A Pruvost, J Mougin, ... ACS nano 8 (3), 2018-2032, 2014 | 81 | 2014 |
One-pot hydrosilylation–protodesilylation of functionalized diarylalkynes: a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4 A Giraud, O Provot, A Hamzé, JD Brion, M Alami Tetrahedron Letters 49 (7), 1107-1110, 2008 | 81 | 2008 |
Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol A Hamze, O Provot, M Alami, JD Brion Organic Letters 7 (25), 5625-5628, 2005 | 81 | 2005 |
Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors I Khelifi, T Naret, D Renko, A Hamze, G Bernadat, J Bignon, C Lenoir, ... European journal of medicinal chemistry 127, 1025-1034, 2017 | 71 | 2017 |
Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity E Rasolofonjatovo, O Provot, A Hamze, J Rodrigo, J Bignon, ... European journal of medicinal chemistry 52, 22-32, 2012 | 70 | 2012 |
Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes A Hamze, O Provot, M Alami, JD Brion Organic Letters 8 (5), 931-934, 2006 | 70 | 2006 |
Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4 D Lamaa, HP Lin, L Zig, C Bauvais, G Bollot, J Bignon, H Levaique, ... Journal of Medicinal Chemistry 61 (15), 6574-6591, 2018 | 66 | 2018 |