| Searching for new allosteric sites in enzymes JA Hardy, JA Wells Current opinion in structural biology 14 (6), 706-715, 2004 | 367 | 2004 |
| Discovery of an allosteric site in the caspases JA Hardy, J Lam, JT Nguyen, T O'Brien, JA Wells Proceedings of the National Academy of Sciences 101 (34), 12461-12466, 2004 | 296 | 2004 |
| Iron in asbestos chemistry and carcinogenicity JA Hardy, AE Aust Chemical Reviews 95 (1), 97-118, 1995 | 280 | 1995 |
| Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules R Tang, CS Kim, DJ Solfiell, S Rana, R Mout, EM Velázquez-Delgado, ... ACS nano 7 (8), 6667-6673, 2013 | 219 | 2013 |
| Allosteric inhibition of the NS2B-NS3 protease from dengue virus M Yildiz, S Ghosh, JA Bell, W Sherman, JA Hardy ACS chemical biology 8 (12), 2744-2752, 2013 | 137 | 2013 |
| The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks JA Hardy, AE Aust Carcinogenesis 16 (2), 319-325, 1995 | 102 | 1995 |
| Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling LE Araya, IV Soni, JA Hardy, O Julien ACS chemical biology 16 (11), 2280-2296, 2021 | 93 | 2021 |
| Mechanism of zinc‐mediated inhibition of caspase‐9 KL Huber, JA Hardy Protein Science 21 (7), 1056-1065, 2012 | 92 | 2012 |
| Zinc-mediated allosteric inhibition of caspase-6 EM Velázquez-Delgado, JA Hardy Journal of Biological Chemistry 287 (43), 36000-36011, 2012 | 89 | 2012 |
| Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules CS Kim, R Mout, Y Zhao, YC Yeh, R Tang, Y Jeong, B Duncan, JA Hardy, ... Bioconjugate chemistry 26 (5), 950-954, 2015 | 87 | 2015 |
| Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases V Raman, N Van Dessel, CL Hall, VE Wetherby, SA Whitney, EL Kolewe, ... Nature Communications 12 (1), 6116, 2021 | 84 | 2021 |
| Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases-3,-6,-7, and-8 SJ Eron, DJ MacPherson, KB Dagbay, JA Hardy ACS chemical biology 13 (5), 1279-1290, 2018 | 81 | 2018 |
| Mechanism of a genetically encoded dark-to-bright reporter for caspase activity SB Nicholls, J Chu, G Abbruzzese, KD Tremblay, JA Hardy Journal of Biological Chemistry 286 (28), 24977-24986, 2011 | 72 | 2011 |
| The unique cofactor region of Zika virus NS2B–NS3 protease facilitates cleavage of key host proteins ME Hill, A Kumar, JA Wells, TC Hobman, O Julien, JA Hardy ACS chemical biology 13 (9), 2398-2405, 2018 | 65 | 2018 |
| Substrate-induced conformational changes occur in all cleaved forms of caspase-6 S Vaidya, EM Velázquez-Delgado, G Abbruzzese, JA Hardy Journal of molecular biology 406 (1), 75-91, 2011 | 64 | 2011 |
| Asbestiform riebeckite (crocidolite) dissolution in the presence of Fe chelators: implications for mineral-induced disease AJ Werner, MF Hochella, GD Guthrie, JA Hardy, AE Aust, JD Rimstidt American Mineralogist 80 (11-12), 1093-1103, 1995 | 62 | 1995 |
| Dissecting an allosteric switch in caspase-7 using chemical and mutational probes JA Hardy, JA Wells Journal of Biological Chemistry 284 (38), 26063-26069, 2009 | 60 | 2009 |
| The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity MP Cicero, S T. Hubl, CJ Harrison, O Littlefield, JA Hardy, HCM Nelson Nucleic acids research 29 (8), 1715-1723, 2001 | 57 | 2001 |
| L2′ loop is critical for caspase‐7 active site formation WA Witkowski, JA Hardy Protein Science 18 (7), 1459-1468, 2009 | 47 | 2009 |
| Phosphorylation regulates assembly of the caspase-6 substrate-binding groove EM Velázquez-Delgado, JA Hardy Structure 20 (4), 742-751, 2012 | 46 | 2012 |
