| Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes DB Rozema, DL Lewis, DH Wakefield, SC Wong, JJ Klein, PL Roesch, ... Proceedings of the National Academy of Sciences 104 (32), 12982-12987, 2007 | 843 | 2007 |
| Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection CI Wooddell, DB Rozema, M Hossbach, M John, HL Hamilton, Q Chu, ... Molecular Therapy 21 (5), 973-985, 2013 | 366 | 2013 |
| Artificial chaperones: protein refolding via sequential use of detergent and cyclodextrin D Rozema, SH Gellman Journal of the American Chemical Society 117 (8), 2373-2374, 1995 | 288 | 1995 |
| Artificial chaperone-assisted refolding of denatured-reduced lysozyme: modulation of the competition between renaturation and aggregation D Rozema, SH Gellman Biochemistry 35 (49), 15760-15771, 1996 | 279 | 1996 |
| Artificial chaperone-assisted refolding of carbonic anhydrase B D Rozema, SH Gellman Journal of Biological Chemistry 271 (7), 3478-3487, 1996 | 268 | 1996 |
| Breaking the bonds: non-viral vectors become chemically dynamic JA Wolff, DB Rozema Molecular Therapy 16 (1), 8-15, 2008 | 216 | 2008 |
| Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules DB Rozema, K Ekena, DL Lewis, AG Loomis, JA Wolff Bioconjugate chemistry 14 (1), 51-57, 2003 | 214 | 2003 |
| Polyconjugates for in vivo delivery of polynucleotides DB Rozema, JE Hagstrom, J Klein, DL Lewis, SD Monahan, ... US Patent 8,137,695, 2012 | 165 | 2012 |
| Artificial chaperone-assisted refolding of citrate synthase DL Daugherty, D Rozema, PE Hanson, SH Gellman Journal of Biological Chemistry 273 (51), 33961-33971, 1998 | 161 | 1998 |
| Co-Injection of a Targeted, Reversibly Masked Endosomolytic Polymer Dramatically Improves the Efficacy of Cholesterol-Conjugated Small Interfering RNAs In Vivo SC Wong, JJ Klein, HL Hamilton, Q Chu, CL Frey, VS Trubetskoy, ... Nucleic acid therapeutics 22 (6), 380-390, 2012 | 133 | 2012 |
| Polyconjugates for in vivo delivery of polynucleotides DB Rozema, DH Wakefield, DL Lewis, J Klein, S Wong, JA Wolff, ... US Patent 8,658,211, 2014 | 131 | 2014 |
| The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities CE Trueblood, VL Boyartchuk, EA Picologlou, D Rozema, CD Poulter, ... Molecular and cellular biology 20 (12), 4381-4392, 2000 | 124 | 2000 |
| Compositions for targeted delivery of siRNA DB Rozema, DL Lewis, DH Wakefield US Patent 8,313,772, 2012 | 121 | 2012 |
| Peptide-based in vivo siRNA delivery system DB Rozema, DH Wakefield, DL Lewis, JA Wolff, AV Blokhin, JD Benson, ... US Patent 8,501,930, 2013 | 113 | 2013 |
| Compositions and methods for drug delivery using pH sensitive molecules VS Trubetskoy, JE Hagstrom, VG Budker, JA Wolff, DB Rozema, ... US Patent 6,919,091, 2005 | 102 | 2005 |
| Delivery of siRNA to cells using polyampholytes V Trubetskoy, D Rozema, S Monahan, V Budker, J Hagstrom, J Wolff US Patent App. 10/368,139, 2004 | 85 | 2004 |
| Compositions and methods for drug delivery using pH sensitive molecules VS Trubetskoy, JE Hagstrom, VG Budker, JA Wolff, DB Rozema, ... US Patent 7,098,032, 2006 | 82 | 2006 |
| Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA P Hadwiger, T Hoffmann, EA Kitas, P Mohr, I Roehl, L Valis, DB Rozema, ... US Patent 9,249,179, 2016 | 81 | 2016 |
| Intravascular delivery of non-viral nucleic acid J Hagstrom, J Wolff, S Monahan, D Rozema, V Budker, P Slattum, ... US Patent App. 10/609,938, 2004 | 81 | 2004 |
| Endosomolytic Modified Poly (Alcohol) and Poly (Amine) Polymers SD Monahan, L Higgs, DH Wakefield, DB Rozema, JA Wolff, JE Hagstrom US Patent App. 12/140,736, 2008 | 75 | 2008 |
