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Matt Sinclair
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Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter
Q Tang, M Sinclair, HS Hasdemir, RA Stein, E Karakas, E Tajkhorshid, ...
Nature communications 14 (1), 7184, 2023
42023
A Gram-negative-selective antibiotic that spares the gut microbiome
KA Muñoz, RJ Ulrich, AK Vasan, M Sinclair, PC Wen, JR Holmes, HY Lee, ...
Nature, 1-8, 2024
22024
Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model
M Sinclair, RA Stein, JH Sheehan, EM Hawes, RM O’Brien, E Tajkhorshid, ...
PNAS nexus 3 (2), pgae036, 2024
12024
Molecular mechanisms of functional impairment for active site mutations in glucose-6-phosphatase catalytic subunit 1 linked to glycogen storage disease type 1a
M Sinclair, RA Stein, JH Sheehan, EM Hawes, RM O’Brien, E Tajkhorshid, ...
bioRxiv, 2023.03. 13.532485, 2023
12023
WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination
J Zhang, Y Yu, X Zou, Y Du, Q Liang, M Gong, Y He, J Luo, D Wu, X Jiang, ...
Nucleic acids research 52 (9), 4969-4984, 2024
2024
Cholesterol as an allosteric regulator of hepatic glucose-6-phosphatase
M Sinclair, DP Claxton, E Tajkhorshid
Biophysical Journal 123 (3), 482a, 2024
2024
Molecular mechanisms of catalytic inhibition for active site mutations in glucose-6-phosphatase catalytic subunit 1 linked to glycogen storage disease
M Sinclair, RA Stein, JH Sheehan, EM Hawes, RM O’Brien, E Tajkhorshid, ...
bioRxiv, 2023
2023
Simulations reveal the role of glucose-6-phosphatase mutations in glycogen storage disease
M Sinclair, J Sheehan, RA Stein, DP Claxton, E Tajkhorshid
Biophysical journal 122 (3), 185a, 2023
2023
Probing the Impact of Lipid Composition on Structure and Dynamics of E. coli Protein Insertase YidC
M Sinclair, E Tajkhorshid
Biophysical Journal 120 (3), 232a, 2021
2021
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