| Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ... Nature biotechnology 34 (2), 184-191, 2016 | 3902 | 2016 |
| Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ... Nature biotechnology 32 (12), 1262-1267, 2014 | 1776 | 2014 |
| Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities KR Sanson, RE Hanna, M Hegde, KF Donovan, C Strand, ME Sullender, ... Nature communications 9 (1), 5416, 2018 | 686 | 2018 |
| Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens FJ Najm, C Strand, KF Donovan, M Hegde, KR Sanson, EW Vaimberg, ... Nature biotechnology 36 (2), 179-189, 2018 | 277 | 2018 |
| Massively parallel assessment of human variants with base editor screens RE Hanna, M Hegde, CR Fagre, PC DeWeirdt, AK Sangree, Z Szegletes, ... Cell 184 (4), 1064-1080. e20, 2021 | 225 | 2021 |
| Optimization of AsCas12a for combinatorial genetic screens in human cells PC DeWeirdt, KR Sanson, AK Sangree, M Hegde, RE Hanna, MN Feeley, ... Nature biotechnology 39 (1), 94-104, 2021 | 127 | 2021 |
| Genetic screens in isogenic mammalian cell lines without single cell cloning PC DeWeirdt, AK Sangree, RE Hanna, KR Sanson, M Hegde, C Strand, ... Nature communications 11 (1), 752, 2020 | 94 | 2020 |
| Genome-wide in vivo CNS screening identifies genes that modify CNS neuronal survival and mHTT toxicity MH Wertz, MR Mitchem, SS Pineda, LJ Hachigian, H Lee, V Lau, ... Neuron 106 (1), 76-89. e8, 2020 | 74 | 2020 |
| Creation of novel protein variants with CRISPR/Cas9-mediated mutagenesis: turning a screening by-product into a discovery tool KF Donovan, M Hegde, M Sullender, EW Vaimberg, CM Johannessen, ... PloS one 12 (1), e0170445, 2017 | 60 | 2017 |
| Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs A Rebendenne, P Roy, B Bonaventure, AL Chaves Valadão, L Desmarets, ... Nature genetics 54 (8), 1090-1102, 2022 | 56 | 2022 |
| Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities. Nat Commun 9: 5416 KR Sanson, RE Hanna, M Hegde, KF Donovan, C Strand, ME Sullender, ... | 51 | 2018 |
| Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens M Hegde, C Strand, RE Hanna, JG Doench PloS one 13 (5), e0197547, 2018 | 46 | 2018 |
| Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2 AK Sangree, AL Griffith, ZM Szegletes, P Roy, PC DeWeirdt, M Hegde, ... Nature Communications 13 (1), 1318, 2022 | 34 | 2022 |
| Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening PC DeWeirdt, AV McGee, F Zheng, I Nwolah, M Hegde, JG Doench Nature Communications 13 (1), 5255, 2022 | 10 | 2022 |
| Up, down, and out: next generation libraries for genome-wide CRISPRa, CRISPRi, and CRISPR-Cas9 knockout genetic screens KR Sanson, RE Hanna, M Hegde, KF Donovan, C Strand, ME Sullender, ... bioRxiv, 356626, 2018 | 8 | 2018 |
| Optimization of Cas12a for multiplexed genome-scale transcriptional activation AL Griffith, F Zheng, AV McGee, NW Miller, ZM Szegletes, G Reint, ... Cell Genomics 3 (9), 2023 | 5 | 2023 |
| Chromatin complex dependencies reveal targeting opportunities in leukemia FJ Najm, P DeWeirdt, MM Moore, SM Bevill, CA El Farran, KA Macias, ... Nature Communications 14 (1), 448, 2023 | 4 | 2023 |
| Scanning mutagenesis of the voltage-gated sodium channel NaV1. 2 using base editing JLB Pablo, SL Cornett, LA Wang, S Jo, T Brünger, N Budnik, M Hegde, ... Cell reports 42 (6), 2023 | 2 | 2023 |
| Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput PH Kennedy, A Alborzian Deh Sheikh, M Balakar, AC Jones, ME Olive, ... Nature Methods, 1-11, 2024 | | 2024 |
| Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB BL Lampson, AS Ramίrez, M Baro, L He, M Hegde, V Koduri, JL Pfaff, ... Cell 187 (9), 2209-2223. e16, 2024 | | 2024 |
