| Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries P Gharahkhani, E Jorgenson, P Hysi, AP Khawaja, S Pendergrass, X Han, ... Nature communications 12 (1), 1258, 2021 | 234 | 2021 |
| The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins D Mérino, M Giam, PD Hughes, OM Siggs, K Heger, LA O'Reilly, ... Journal Of Cell Biology 186 (3), 355-362, 2009 | 234 | 2009 |
| Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression JE Craig, X Han, A Qassim, M Hassall, JNC Bailey, TG Kinzy, AP Khawaja, ... Nature Genetics, 1-7, 2020 | 232 | 2020 |
| Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity T Souma, SW Tompson, BR Thomson, OM Siggs, K Kizhatil, S Yamaguchi, ... Journal of clinical investigation 126 (7), 2575-2587, 2016 | 195 | 2016 |
| Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma S MacGregor, JS Ong, J An, X Han, T Zhou, OM Siggs, MH Law, ... Nature genetics 50 (8), 1067-1071, 2018 | 171 | 2018 |
| MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands K Brandl, L Sun, C Neppl, OM Siggs, SM Le Gall, W Tomisato, X Li, X Du, ... Proceedings of the National Academy of Sciences 107 (46), 19967-19972, 2010 | 165 | 2010 |
| Unravelling the association of partial T-cell immunodeficiency and immune dysregulation A Liston, A Enders, OM Siggs Nature Reviews Immunology 8 (7), 545-558, 2008 | 155 | 2008 |
| Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions OM Siggs, LA Miosge, AL Yates, EM Kucharska, D Sheahan, T Brdicka, ... Immunity 27 (6), 912-926, 2007 | 148 | 2007 |
| The BTB-ZF transcription factors OM Siggs, B Beutler Cell cycle 11 (18), 3358-3369, 2012 | 136 | 2012 |
| iRhom2 is required for the secretion of mouse TNFα OM Siggs, N Xiao, Y Wang, H Shi, W Tomisato, X Li, Y Xia, B Beutler Blood, The Journal of the American Society of Hematology 119 (24), 5769-5771, 2012 | 105 | 2012 |
| The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow OM Siggs, CN Arnold, C Huber, E Pirie, Y Xia, P Lin, D Nemazee, ... Nature immunology 12 (5), 434-440, 2011 | 105 | 2011 |
| A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity CN Arnold, E Pirie, P Dosenovic, GM McInerney, Y Xia, N Wang, X Li, ... Proceedings of the National Academy of Sciences 109 (31), 12286-12293, 2012 | 103 | 2012 |
| An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence M Berger, P Krebs, K Crozat, X Li, BA Croker, OM Siggs, D Popkin, X Du, ... Nature immunology 11 (4), 335-343, 2010 | 103 | 2010 |
| The why and how of thymocyte negative selection OM Siggs, LE Makaroff, A Liston Current opinion in immunology 18 (2), 175-183, 2006 | 102 | 2006 |
| Angiopoietin-1 is required for Schlemm’s canal development in mice and humans BR Thomson, T Souma, SW Tompson, T Onay, K Kizhatil, OM Siggs, ... Journal of clinical investigation 127 (12), 4421-4436, 2017 | 94 | 2017 |
| Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma MS Awadalla, JH Fingert, BE Roos, S Chen, R Holmes, SL Graham, ... American journal of ophthalmology 159 (1), 124-130, 2015 | 94 | 2015 |
| Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses DE Zak, F Schmitz, ES Gold, AH Diercks, JJ Peschon, JS Valvo, ... Proceedings of the National Academy of Sciences 108 (28), 11536-11541, 2011 | 77 | 2011 |
| X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C OM Siggs, B Schnabl, B Webb, B Beutler Proceedings of the National Academy of Sciences 108 (19), 7890-7895, 2011 | 70 | 2011 |
| Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variants E Souzeau, OM Siggs, T Zhou, A Galanopoulos, T Hodson, D Taranath, ... European Journal of Human Genetics 25 (7), 839-847, 2017 | 58 | 2017 |
| ENU-induced phenovariance in mice: inferences from 587 mutations CN Arnold, MJ Barnes, M Berger, AL Blasius, K Brandl, B Croker, ... BMC research notes 5, 1-14, 2012 | 56 | 2012 |
