| The carbonate radical and related oxidants derived from bicarbonate buffer DB Medinas, G Cerchiaro, DF Trindade, O Augusto IUBMB life 59 (4‐5), 255-262, 2007 | 219 | 2007 |
| IRE1 signaling exacerbates Alzheimer’s disease pathogenesis C Duran-Aniotz, VH Cornejo, S Espinoza, ÁO Ardiles, DB Medinas, ... Acta neuropathologica 134, 489-506, 2017 | 204 | 2017 |
| ER dysfunction and protein folding stress in ALS S Matus, V Valenzuela, DB Medinas, C Hetz International journal of cell biology 2013 (1), 674751, 2013 | 133 | 2013 |
| ALS‐linked protein disulfide isomerase variants cause motor dysfunction U Woehlbier, A Colombo, MJ Saaranen, V Pérez, J Ojeda, FJ Bustos, ... The EMBO journal 35 (8), 845-865, 2016 | 125 | 2016 |
| Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis DB Medinas, P Rozas, F Martínez Traub, U Woehlbier, RH Brown, ... Proceedings of the National Academy of Sciences 115 (32), 8209-8214, 2018 | 112 | 2018 |
| The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator … G Campos, W Schmidt-Heck, A Ghallab, K Rochlitz, L Pütter, DB Medinas, ... Archives of toxicology 88, 1267-1280, 2014 | 78 | 2014 |
| A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity DB Medinas, FC Gozzo, LFA Santos, AH Iglesias, O Augusto Free Radical Biology and Medicine 49 (6), 1046-1053, 2010 | 67 | 2010 |
| The protein-disulfide isomerase ERp57 regulates the steady-state levels of the prion protein M Torres, DB Medinas, JM Matamala, U Woehlbier, VH Cornejo, T Solda, ... Journal of Biological Chemistry 290 (39), 23631-23645, 2015 | 66 | 2015 |
| Proteostasis disturbance in amyotrophic lateral sclerosis DB Medinas, V Valenzuela, C Hetz Human molecular genetics 26 (R2), R91-R104, 2017 | 61 | 2017 |
| Adaptive preconditioning in neurological diseases–therapeutic insights from proteostatic perturbations B Mollereau, NM Rzechorzek, BD Roussel, M Sedru, DM Van den Brink, ... Brain research 1648, 603-616, 2016 | 54 | 2016 |
| Functional role of the disulfide isomerase ERp57 in axonal regeneration V Castillo, M Oñate, U Woehlbier, P Rozas, C Andreu, D Medinas, ... PloS one 10 (9), e0136620, 2015 | 54 | 2015 |
| Common ground: stem cell approaches find shared pathways underlying ALS S Matus, DB Medinas, C Hetz Cell stem cell 14 (6), 697-699, 2014 | 47 | 2014 |
| Peroxymonocarbonate and carbonate radical displace the hydroxyl-like oxidant in the Sod1 peroxidase activity under physiological conditions DB Medinas, JC Toledo, Jr, G Cerchiaro, AT do-Amaral, L de-Rezende, ... Chemical research in toxicology 22 (4), 639-648, 2009 | 46 | 2009 |
| The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability P Rozas, L Bargsted, F Martínez, C Hetz, DB Medinas Neuroscience letters 636, 9-15, 2017 | 45 | 2017 |
| Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein–tyrosine nitration to protein–cysteine nitrosation DC Fernandes, DB Medinas, MJM Alves, O Augusto Free radical biology and medicine 38 (2), 189-200, 2005 | 43 | 2005 |
| Generation of singlet oxygen by the glyoxal–peroxynitrite system J Massari, R Tokikawa, DB Medinas, JPF Angeli, P Di Mascio, ... Journal of the American Chemical Society 133 (51), 20761-20768, 2011 | 39 | 2011 |
| Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis S Beltran, M Nassif, E Vicencio, J Arcos, L Labrador, BI Cortes, C Cortez, ... Molecular Neurodegeneration 14, 1-18, 2019 | 27 | 2019 |
| Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging F Cabral‐Miranda, G Tamburini, G Martinez, AO Ardiles, DB Medinas, ... The EMBO Journal 41 (22), e111952, 2022 | 25 | 2022 |
| Fine-tuning ER stress signal transducers to treat amyotrophic lateral sclerosis DB Medinas, JV González, P Falcon, C Hetz Frontiers in Molecular Neuroscience 10, 216, 2017 | 23 | 2017 |
| The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis C Duran-Aniotz, N Poblete, C Rivera-Krstulovic, ÁO Ardiles, ... Molecular Therapy 31 (7), 2240-2256, 2023 | 22 | 2023 |
