Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter JA Plumb, G Strathdee, J Sludden, SB Kaye, R Brown Cancer research 60 (21), 6039-6044, 2000 | 656 | 2000 |
A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer G Strathdee, MJ MacKean, M Illand, R Brown Oncogene 18 (14), 2335-2341, 1999 | 436 | 1999 |
Induction of epigenetic alterations by dietary and other environmental factors JC Mathers, G Strathdee, CL Relton Advances in genetics 71, 3-39, 2010 | 352 | 2010 |
CpG island methylation of DNA damage response genes in advanced ovarian cancer JM Teodoridis, J Hall, S Marsh, HD Kannall, C Smyth, J Curto, N Siddiqui, ... Cancer research 65 (19), 8961-8967, 2005 | 296 | 2005 |
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors K Appleton, HJ Mackay, I Judson, JA Plumb, C McCormick, G Strathdee, ... Journal of Clinical Oncology 25 (29), 4603-4609, 2007 | 262 | 2007 |
Epigenomics and epigenetic therapy of cancer R Brown, G Strathdee Trends in molecular medicine 8 (4), S43-S48, 2002 | 255 | 2002 |
Epigenetic versus genetic alterations in the inactivation of E-cadherin G Strathdee Seminars in cancer biology 12 (5), 373-379, 2002 | 249 | 2002 |
Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes G Strathdee, K Appleton, M Illand, DWM Millan, J Sargent, J Paul, ... The American journal of pathology 158 (3), 1121-1127, 2001 | 249 | 2001 |
Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers SH Wei, CM Chen, G Strathdee, J Harnsomburana, CR Shyu, ... Clinical Cancer Research 8 (7), 2246-2252, 2002 | 235 | 2002 |
Aberrant DNA methylation in cancer: potential clinical interventions G Strathdee, R Brown Expert reviews in molecular medicine 4 (4), 1-17, 2002 | 177 | 2002 |
Analysis of the CAVEOLIN-1 gene at human chromosome 7q31. 1 in primary tumours and tumour-derived cell lines AFL Hurlstone, G Reid, JR Reeves, J Fraser, G Strathdee, M Rahilly, ... Oncogene 18 (10), 1881-1890, 1999 | 166 | 1999 |
Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis G Strathdee, TL Holyoake, A Sim, A Parker, DG Oscier, JV Melo, S Meyer, ... Clinical Cancer Research 13 (17), 5048-5055, 2007 | 158 | 2007 |
Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker JM Teodoridis, G Strathdee, R Brown Drug Resistance Updates 7 (4-5), 267-278, 2004 | 153 | 2004 |
Analysis of clinical variation seen in patients with 18q terminal deletions G Strathdee, EH Zackai, R Shapiro, J Kamholz, J Overhauser American journal of medical genetics 59 (4), 476-483, 1995 | 101 | 1995 |
Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene G Strathdee, BR Davies, JK Vass, N Siddiqui, R Brown Carcinogenesis 25 (5), 693-701, 2004 | 97 | 2004 |
Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy G Strathdee, JK Vass, KA Oien, N Siddiqui, J Curto-Garcia, R Brown Gynecologic Oncology 97 (3), 898-903, 2005 | 84 | 2005 |
Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma S Smetsers, J Muter, C Bristow, L Patel, K Chandler, D Bonney, RF Wynn, ... Familial cancer 11, 661-665, 2012 | 78 | 2012 |
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours JC Lindsey, ME Lusher, G Strathdee, R Brown, RJ Gilbertson, S Bailey, ... International journal of cancer 118 (2), 346-352, 2006 | 78 | 2006 |
HOXA5 is targeted by cell-type-specific CpG island methylation in normal cells and during the development of acute myeloid leukaemia G Strathdee, A Sim, R Soutar, TL Holyoake, R Brown Carcinogenesis 28 (2), 299-309, 2007 | 69 | 2007 |
Early life trauma, depression and the glucocorticoid receptor gene–an epigenetic perspective C Smart, G Strathdee, S Watson, C Murgatroyd, RH McAllister-Williams Psychological medicine 45 (16), 3393-3410, 2015 | 67 | 2015 |