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James Z Deng
James Z Deng
在 merck.com 的电子邮件经过验证
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引用次数
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年份
Copper-facilitated Suzuki reactions: Application to 2-heterocyclic boronates
JZ Deng, DV Paone, AT Ginnetti, H Kurihara, SD Dreher, SA Weissman, ...
Organic Letters 11 (2), 345-347, 2009
2352009
Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine:  Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2 …
DV Paone, AW Shaw, DN Nguyen, CS Burgey, JZ Deng, SA Kane, ...
Journal of medicinal chemistry 50 (23), 5564-5567, 2007
1642007
Reduction of Aflatoxin B1 Dialdehyde by Rat and Human Aldo-keto Reductases
FP Guengerich, H Cai, M McMahon, JD Hayes, TR Sutter, JD Groopman, ...
Chemical research in toxicology 14 (6), 727-737, 2001
962001
An Intercalated and Thermally Stable FAPY Adduct of Aflatoxin B1 in a DNA Duplex:  Structural Refinement from 1H NMR
H Mao, Z Deng, F Wang, TM Harris, MP Stone
Biochemistry 37 (13), 4374-4387, 1998
851998
Low molecular weight cationic lipids for oligonucleotide delivery
JA Bawiec III, ZJ Deng
US Patent 9,029,604, 2015
822015
Unraveling the aflatoxin− FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1
KL Brown, JZ Deng, RS Iyer, LG Iyer, MW Voehler, MP Stone, CM Harris, ...
Journal of the American Chemical Society 128 (47), 15188-15199, 2006
682006
Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the …
CS Burgey, DV Paone, AW Shaw, JZ Deng, DN Nguyen, CM Potteiger, ...
Organic Letters 10 (15), 3235-3238, 2008
672008
Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
BW Trotter, KK Nanda, CS Burgey, CM Potteiger, JZ Deng, AI Green, ...
Bioorganic & medicinal chemistry letters 21 (8), 2354-2358, 2011
642011
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization
JZ Deng, DR McMasters, PMA Rabbat, PD Williams, CA Coburn, Y Yan, ...
Bioorganic & medicinal chemistry letters 15 (20), 4411-4416, 2005
592005
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine
CS Burgey, CA Stump, DN Nguyen, JZ Deng, AG Quigley, BR Norton, ...
Bioorganic & medicinal chemistry letters 16 (19), 5052-5056, 2006
562006
CGRP receptor antagonists
CS Burgey, ZJ Deng, DN Nguyen, DV Paone, AW Shaw, TM Williams
US Patent 6,953,790, 2005
362005
Expanding the scope of the Cu assisted Suzuki–Miyaura reaction
BM Crowley, CM Potteiger, JZ Deng, CK Prier, DV Paone, CS Burgey
Tetrahedron letters 52 (39), 5055-5059, 2011
322011
CGRP receptor antagonists
CS Burgey, ZJ Deng, DN Nguyen, DV Paone, AW Shaw, TM Williams
US Patent 7,235,545, 2007
302007
CGRP receptor antagonists
CS Burgey, DV Paone, AW Shaw, DN Nguyen, ZJ Deng, TM Williams, ...
US Patent 8,039,460, 2011
272011
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
PG Nantermet, CS Burgey, KA Robinson, JM Pellicore, CL Newton, ...
Bioorganic & medicinal chemistry letters 15 (11), 2771-2775, 2005
272005
The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery
Y Zhang, L Arrington, D Boardman, J Davis, Y Xu, K DiFelice, S Stirdivant, ...
Journal of Controlled Release 174, 7-14, 2014
252014
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines
CS Burgey, CM Potteiger, JZ Deng, SD Mosser, CA Salvatore, S Yu, ...
Bioorganic & medicinal chemistry letters 19 (22), 6368-6372, 2009
242009
CGRP receptor antagonists
CS Burgey, ZJ Deng, DN Nguyen, DV Paone, AW Shaw, TM Williams
US Patent 7,534,784, 2009
212009
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918
DV Paone, DN Nguyen, AW Shaw, CS Burgey, CM Potteiger, JZ Deng, ...
Bioorganic & medicinal chemistry letters 21 (9), 2683-2686, 2011
182011
A novel and efficient synthesis of 2, 5-substituted 1, 2, 4-triazol-3-ones
JZ Deng, CS Burgey
Tetrahedron letters 46 (46), 7993-7996, 2005
182005
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