| Impact of high-throughput screening in biomedical research R Macarron, MN Banks, D Bojanic, DJ Burns, DA Cirovic, T Garyantes, ... Nature reviews Drug discovery 10 (3), 188-195, 2011 | 1590 | 2011 |
| Identification of novel isoform-selective inhibitors within class I histone deacetylases E Hu, E Dul, CM Sung, Z Chen, R Kirkpatrick, GF Zhang, K Johanson, ... Journal of Pharmacology and Experimental Therapeutics 307 (2), 720-728, 2003 | 509 | 2003 |
| Critical review of the role of HTS in drug discovery R Macarron Drug discovery today 11 (7-8), 277-279, 2006 | 321 | 2006 |
| Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase D Dhanak, KJ Duffy, VK Johnston, J Lin-Goerke, M Darcy, AN Shaw, B Gu, ... Journal of Biological Chemistry 277 (41), 38322-38327, 2002 | 256 | 2002 |
| Enhancements of screening collections to address areas of unmet medical need: an industry perspective DH Drewry, R Macarron Current opinion in chemical biology 14 (3), 289-298, 2010 | 167 | 2010 |
| Design and implementation of high throughput screening assays R Macarrón, RP Hertzberg Molecular biotechnology 47, 270-285, 2011 | 117 | 2011 |
| Synergism of Trichoderma reesei cellulases while degrading different celluloses B Nidetzky, M Hayn, R Macarron, W Steiner Biotechnology letters 15, 71-76, 1993 | 92 | 1993 |
| Mode of action of endoglucanase III from Trichoderma reesei R Macarron, C Acebal, MP Castillon, JM Dominguez, I De la Mata, ... Biochemical Journal 289 (3), 867-873, 1993 | 83 | 1993 |
| A standard operating procedure for assessing liquid handler performance in high-throughput screening PB Taylor, S Ashman, SM Baddeley, SL Bartram, CD Battle, BC Bond, ... Journal of biomolecular screening 7 (6), 554-569, 2002 | 75 | 2002 |
| Identification of an essential glutamate residue in the active site of endoglucanase III from Trichoderma reesei R Macarron, J Van Beeumen, B Henrissat, I de la Mata, M Claeyssens FEBS letters 316 (2), 137-140, 1993 | 65 | 1993 |
| Novel antibacterials: a genomics approach to drug discovery PF Chan, R Macarron, DJ Payne, M Zalacain, DJ Holmes Current Drug Targets-Infectious Disorders 2 (4), 291-308, 2002 | 62 | 2002 |
| Nuisance compounds, PAINS filters, and dark chemical matter in the GSK HTS collection SJ Chakravorty, J Chan, MN Greenwood, I Popa-Burke, KS Remlinger, ... SLAS Discovery: Advancing Life Sciences R&D 23 (6), 532-545, 2018 | 61 | 2018 |
| Process validation and screen reproducibility in high-throughput screening I Coma, L Clark, E Diez, G Harper, J Herranz, G Hofmann, M Lennon, ... Journal of biomolecular screening 14 (1), 66-76, 2009 | 56 | 2009 |
| A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology R Macarrón, L Mensah, C Cid, C Carranza, N Benson, AJ Pope, E Dı́ez Analytical biochemistry 284 (2), 183-190, 2000 | 49 | 2000 |
| Design and implementation of high throughput screening assays R Macarrón, RP Hertzberg High throughput screening: methods and protocols, 1-29, 2002 | 48 | 2002 |
| Design and implementation of high-throughput screening assays R Macarrón, RP Hertzberg High Throughput Screening: Methods and Protocols, Second Edition, 1-32, 2009 | 45 | 2009 |
| Mechanisms of thermoinactivation of endoglucanase I from Trichoderma reesei QM 9414 JM Dominguez, C Acebal, J Jimenez, I De La Mata, R Macarron, ... Biochemical journal 287 (2), 583-588, 1992 | 29 | 1992 |
| The effect of triton concentration on the activity of undecaprenyl pyrophosphate synthase inhibitors H Li, J Huang, X Jiang, M Seefeld, M McQueney, R Macarron SLAS Discovery 8 (6), 712-715, 2003 | 25 | 2003 |
| Applications of CRISPR genome editing technology in drug target identification and validation Q Lu, GP Livi, S Modha, K Yusa, R Macarrón, DJ Dow Expert opinion on drug discovery 12 (6), 541-552, 2017 | 24 | 2017 |
| Family A cellulases: two essential tryptophan residues in endoglucanase III from Trichoderma reesei R Macarrón, B Henrissat, M Claeyssens Biochimica et Biophysica Acta (BBA)-General Subjects 1245 (2), 187-190, 1995 | 23 | 1995 |
