Unlocking de novo antibody design with generative artificial intelligence A Shanehsazzadeh, S Bachas, M McPartlon, G Kasun, JM Sutton, ... bioRxiv, 2023.01. 08.523187, 2023 | 46 | 2023 |
Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness S Bachas, G Rakocevic, D Spencer, AV Sastry, R Haile, JM Sutton, ... BioRxiv, 2022.08. 16.504181, 2022 | 46 | 2022 |
Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR S Bachas, C Eginton, D Gunio, H Wade Proceedings of the National Academy of Sciences 108 (27), 11046-11051, 2011 | 45 | 2011 |
Allosteric coupling via distant disorder-to-order transitions C Eginton, WJ Cressman, S Bachas, H Wade, D Beckett Journal of molecular biology 427 (8), 1695-1704, 2015 | 35 | 2015 |
Convergent use of heptacoordination for cation selectivity by RNA and protein metalloregulators ST Bachas, AR Ferré-D'Amaré Cell chemical biology 25 (8), 962-973. e5, 2018 | 26 | 2018 |
Unlocking de novo antibody design with generative artificial intelligence. bioRxiv A Shanehsazzadeh, S Bachas, M McPartlon, G Kasun, JM Sutton, ... Posted online January, 2023 | 13 | 2023 |
Solution binding and structural analyses reveal potential multidrug resistance functions for SAV2435 and CTR107 and other GyrI-like proteins A Moreno, JR Froehlig, S Bachas, D Gunio, T Alexander, A Vanya, ... Biochemistry 55 (34), 4850-4863, 2016 | 11 | 2016 |
In vitro validated antibody design against multiple therapeutic antigens using generative inverse folding A Shanehsazzadeh, J Alverio, G Kasun, S Levine, JA Khan, C Chung, ... bioRxiv, 2023.12. 08.570889, 2023 | 6 | 2023 |
Unlocking de novo antibody design with generative artificial intelligence. bioRxiv (2023) A Shanehsazzadeh, S Bachas, G Kasun, JM Sutton, AK Steiger, R Shuai, ... URL https://www. biorxiv. org/content/early/2023/01/09/2023.01 8, 0 | 5 | |
Charge is Major Determinant of Activation of the Ligand‐Responsive Multidrug Resistance Gene Regulator, BmrR S Bachas, B Kohrs, H Wade ChemMedChem 11 (10), 1038-1041, 2016 | 4 | 2016 |
Unconventional coupling between ligand recognition and allosteric control in the multidrug resistance gene regulator, BmrR S Bachas, B Kohrs, H Wade ChemMedChem 12 (6), 426-430, 2017 | 3 | 2017 |
AIntibody: an experimentally validated in silico antibody discovery design challenge MF Erasmus, L Spector, F Ferrara, R DiNiro, TJ Pohl, K Perea-Schmittle, ... Nature Biotechnology, 1-6, 2024 | 1 | 2024 |
ENGINEERED GYRI-LIKE MUTEIN APTAMERS, AND RELATED METHODS H Cho, ST Bachas US Patent App. 18/733,814, 2024 | | 2024 |
Engineered gyri-like mutein aptamers, and related methods HD Cho, ST Bachas US Patent 12,104,201, 2024 | | 2024 |
Back Cover: Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR (ChemMedChem 6/2017) S Bachas, B Kohrs, H Wade ChemMedChem 12 (6), 475-475, 2017 | | 2017 |
Induced fit in the specific recognition of transition metal ions by a gene-regulatory RNA ST Bachas, AR Ferre-D'Amare ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 73, A37-A37, 2017 | | 2017 |
Cover Picture: Charge is Major Determinant of Activation of the Ligand‐Responsive Multidrug Resistance Gene Regulator, BmrR (ChemMedChem 10/2016) S Bachas, B Kohrs, H Wade ChemMedChem 11 (10), 1022-1022, 2016 | | 2016 |
Multidrug recognition and Multidrug transcription activation by the gene regulator, BmrR ST Bachas Johns Hopkins University, 2014 | | 2014 |
Allosteric Coupling via Communication of Distal Disorder-To-Order Transitions D Beckett, C Eginton, S Bachas, H Wade Biophysical Journal 106 (2), 438a, 2014 | | 2014 |