| Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity RM Hoet, EH Cohen, RB Kent, K Rookey, S Schoonbroodt, S Hogan, ... Nature biotechnology 23 (3), 344-348, 2005 | 459 | 2005 |
| DegS and YaeL participate sequentially in the cleavage of RseA to activate the ςE-dependent extracytoplasmic stress response BM Alba, JA Leeds, C Onufryk, CZ Lu, CA Gross Genes & development 16 (16), 2156-2168, 2002 | 421 | 2002 |
| Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu RP Morris, JA Leeds, HU Naegeli, L Oberer, K Memmert, E Weber, ... Journal of the American Chemical Society 131 (16), 5946-5955, 2009 | 214 | 2009 |
| Diagnosing antimicrobial resistance CAD Burnham, J Leeds, P Nordmann, J O'Grady, J Patel Nature Reviews Microbiology 15 (11), 697-703, 2017 | 202 | 2017 |
| Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection MJ LaMarche, JA Leeds, A Amaral, JT Brewer, SM Bushell, G Deng, ... Journal of medicinal chemistry 55 (5), 2376-2387, 2012 | 142 | 2012 |
| In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin JA Leeds, M Sachdeva, S Mullin, SW Barnes, A Ruzin Journal of Antimicrobial Chemotherapy 69 (1), 41-44, 2014 | 123 | 2014 |
| The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors KL Blake, AJ O'Neill, D Mengin‐Lecreulx, PJF Henderson, JM Bostock, ... Molecular microbiology 72 (2), 335-343, 2009 | 111 | 2009 |
| RfaH enhances elongation of Escherichia coli hlyCABD mRNA JA Leeds, RA Welch Journal of bacteriology 178 (7), 1850-1857, 1996 | 108 | 1996 |
| Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections K Mullane, C Lee, A Bressler, M Buitrago, K Weiss, K Dabovic, ... Antimicrobial agents and chemotherapy 59 (3), 1435-1440, 2015 | 104 | 2015 |
| Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C60-Secondary Ion Mass Spectrometry H Tian, DA Six, T Krucker, JA Leeds, N Winograd Analytical chemistry 89 (9), 5050-5057, 2017 | 102 | 2017 |
| Enhancing transcription through the Escherichia coli hemolysin operon, hlyCABD: RfaH and upstream JUMPStart DNA sequences function together via a postinitiation mechanism JA Leeds, RA Welch Journal of bacteriology 179 (11), 3519-3527, 1997 | 92 | 1997 |
| Battling against host phagocytes: the wherefore of the RTX family of toxins? RA Welch, ME Bauer, AD Kent, JA Leeds, M Moayeri, LB Regassa, ... Infectious Agents and Disease 4 (4), 254-272, 1995 | 89 | 1995 |
| Peptide deformylase as an antibacterial target: a critical assessment JA Leeds, CR Dean Current opinion in pharmacology 6 (5), 445-452, 2006 | 88 | 2006 |
| Efficacy of LFF571 in a hamster model of Clostridium difficile infection A Trzasko, JA Leeds, J Praestgaard, MJ LaMarche, D McKenney Antimicrobial agents and chemotherapy 56 (8), 4459-4462, 2012 | 80 | 2012 |
| Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases Y Yuan, M Sachdeva, JA Leeds, TC Meredith Journal of bacteriology 194 (19), 5171-5184, 2012 | 75 | 2012 |
| Recent developments in antibacterial drug discovery: microbe-derived natural products–from collection to the clinic JA Leeds, EK Schmitt, P Krastel Expert opinion on investigational drugs 15 (3), 211-226, 2006 | 63 | 2006 |
| Pseudomonas aeruginosa Directly Shunts β-Oxidation Degradation Intermediates into De Novo Fatty Acid Biosynthesis Y Yuan, JA Leeds, TC Meredith Journal of bacteriology 194 (19), 5185-5196, 2012 | 61 | 2012 |
| Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571 JA Leeds, M Sachdeva, S Mullin, J Dzink-Fox, MJ LaMarche Antimicrobial agents and chemotherapy 56 (8), 4463-4465, 2012 | 58 | 2012 |
| Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids MJ LaMarche, JA Leeds, K Amaral, JT Brewer, SM Bushell, JM Dewhurst, ... Journal of medicinal chemistry 54 (23), 8099-8109, 2011 | 51 | 2011 |
| 2-Aminotetralones: novel inhibitors of MurA and MurZ CJ Dunsmore, K Miller, KL Blake, SG Patching, PJF Henderson, ... Bioorganic & medicinal chemistry letters 18 (5), 1730-1734, 2008 | 48 | 2008 |
