| Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria SP Mathupala, YH Ko, PL Pedersen Oncogene 25 (34), 4777-4786, 2006 | 908 | 2006 |
| Hexokinase-2 bound to mitochondria: cancer's stygian link to the “Warburg Effect” and a pivotal target for effective therapy SP Mathupala, YH Ko, PL Pedersen Seminars in cancer biology 19 (1), 17-24, 2009 | 644 | 2009 |
| Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions SP Mathupala, A Rempel, PL Pedersen Journal of Biological Chemistry 276 (46), 43407-43412, 2001 | 476 | 2001 |
| Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention PL Pedersen, S Mathupala, A Rempel, JF Geschwind, YH Ko Biochimica et Biophysica Acta (BBA)-Bioenergetics 1555 (1-3), 14-20, 2002 | 447 | 2002 |
| Glucose catabolism in cancer cells: the type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53 SP Mathupala, C Heese, PL Pedersen Journal of Biological Chemistry 272 (36), 22776-22780, 1997 | 307 | 1997 |
| Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role … SP Mathupala, A Rempel, PL Pedersen Journal of bioenergetics and biomembranes 29, 339-343, 1997 | 306 | 1997 |
| Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase A Rempel, SP Mathupala, CA Griffin, AL Hawkins, PL Pedersen Cancer research 56 (11), 2468-2471, 1996 | 260 | 1996 |
| Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study CB Colen, Y Shen, F Ghoddoussi, P Yu, TB Francis, BJ Koch, ... Neoplasia 13 (7), 620-632, 2011 | 235 | 2011 |
| The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies SP Mathupala, YH Ko, PL Pedersen Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (6-7), 1225-1230, 2010 | 213 | 2010 |
| Glucose Catabolism in Cancer Cells.: ISOLATION, SEQUENCE, AND ACTIVITY OF THE PROMOTER FOR TYPE II HEXOKINASE SP Mathupala, A Rempel, PL Pedersen Journal of Biological Chemistry 270 (28), 16918-16925, 1995 | 209 | 1995 |
| Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study SP Mathupala, P Parajuli, AE Sloan Neurosurgery 55 (6), 1410-1419, 2004 | 198 | 2004 |
| Glucose metabolism in cancer: evidence that demethylation events play a role in activating type II hexokinase gene expression A Goel, SP Mathupala, PL Pedersen Journal of Biological Chemistry 278 (17), 15333-15340, 2003 | 192 | 2003 |
| Purification and characterization of a highly thermostable novel pullulanase from Clostridium thermohydrosulfuricum BC Saha, SP Mathupala, JG Zeikus Biochemical Journal 252 (2), 343-348, 1988 | 130 | 1988 |
| Sequencing of the amylopullulanase (apu) gene of Thermoanaerobacter ethanolicus 39E, and identification of the active site by site-directed mutagenesis SP Mathupala, SE Lowe, SM Podkovyrov, JG Zeikus Journal of Biological Chemistry 268 (22), 16332-16344, 1993 | 121 | 1993 |
| Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis SP Mathupala, CB Colen, P Parajuli, AE Sloan Journal of bioenergetics and biomembranes 39, 73-77, 2007 | 111 | 2007 |
| Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study CB Colen, N Seraji-Bozorgzad, B Marples, MP Galloway, AE Sloan, ... Neurosurgery 59 (6), 1313-1324, 2006 | 102 | 2006 |
| Delivery of small-interfering RNA (siRNA) to the brain: WO2008033285; 2008 SP Mathupala Expert opinion on therapeutic patents 19 (2), 137-140, 2009 | 101 | 2009 |
| Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP A Rempel, SP Mathupala, PL Pedersen FEBS letters 385 (3), 233-237, 1996 | 79 | 1996 |
| Characterization of an endo-Acting Amylopullulanase from Thermoanaerobacter Strain B6A BC Saha, R Lamed, CY Lee, SP Mathupala, JG Zeikus Applied and environmental microbiology 56 (4), 881-886, 1990 | 67 | 1990 |
| Substrate competition and specificity at the active site of amylopullulanase from Clostridium thermohydrosulfuricum S Mathupala, BC Saha, JG Zeikus Biochemical and biophysical research communications 166 (1), 126-132, 1990 | 56 | 1990 |
Yimin ShenRadiology, Wayne State University School of Medicine在 wayne.edu 的电子邮件经过验证
