Microtubules, microtubule-interfering agents and apoptosis F Mollinedo, C Gajate Apoptosis 8 (5), 413-450, 2003 | 644 | 2003 |
Lipid rafts as major platforms for signaling regulation in cancer F Mollinedo, C Gajate Advances in biological regulation 57, 130-146, 2015 | 333 | 2015 |
The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells C Gajate, F Mollinedo Blood, The Journal of the American Society of Hematology 98 (13), 3860-3863, 2001 | 324 | 2001 |
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts C Gajate, F Mollinedo Blood 109 (2), 711-719, 2007 | 304 | 2007 |
Selective Induction of Apoptosis in Cancer Cells by the Ether Lipid ET-18-OCH3 (Edelfosine): Molecular Structure Requirements, Cellular Uptake, and Protection by Bcl-2 and … F Mollinedo, JL Fernández-Luna, C Gajate, B Martín-Martín, A Benito, ... Cancer research 57 (7), 1320-1328, 1997 | 285 | 1997 |
Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis C Gajate, E del Canto-Jañez, AU Acuña, F Amat-Guerri, E Geijo, ... The Journal of experimental medicine 200 (3), 353-365, 2004 | 255 | 2004 |
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy C Gajate, F Mollinedo Journal of Biological Chemistry 280 (12), 11641-11647, 2005 | 229 | 2005 |
Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH3 (edelfosine), a proapoptotic agent in tumor cells C Gajate, F Mollinedo Current drug metabolism 3 (5), 491-525, 2002 | 222 | 2002 |
Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy F Mollinedo, C Gajate Drug resistance updates 9 (1-2), 51-73, 2006 | 196 | 2006 |
Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts F Mollinedo, C Gajate Journal of lipid research 61 (5), 611-635, 2020 | 183 | 2020 |
Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium A Macho, MA Calzado, J Muñoz-Blanco, C Gómez-Díaz, C Gajate, ... Cell Death & Differentiation 6 (2), 155-165, 1999 | 177 | 1999 |
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid‐induced apoptosis C Gajate, RI Fonteriz, C Cabaner, G Alvarez‐Noves, Y Alvarez‐Rodriguez, ... International journal of cancer 85 (5), 674-682, 2000 | 175 | 2000 |
Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils F MOLLINEDO, M NAKAJIMA, A LLORENS, E BARBOSA, S CALLEJO, ... Biochemical Journal 327 (3), 917-923, 1997 | 167 | 1997 |
ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor F Mollinedo, C Gajate, S Martín-Santamaría, F Gago Current medicinal chemistry 11 (24), 3163-3184, 2004 | 166 | 2004 |
Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils F Mollinedo, J Calafat, H Janssen, B Martín-Martín, J Canchado, ... The Journal of Immunology 177 (5), 2831-2841, 2006 | 146 | 2006 |
Involvement of mitochondria and caspase‐3 in ET‐18‐OCH3‐induced apoptosis of human leukemic cells C Gajate, AM Santos‐Beneit, A Macho, MC Lazaro, ... International journal of cancer 86 (2), 208-218, 2000 | 146 | 2000 |
Lipid raft-targeted therapy in multiple myeloma F Mollinedo, J De la Iglesia-Vicente, C Gajate, ... Oncogene 29 (26), 3748-3757, 2010 | 141 | 2010 |
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells C Gajate, F Gonzalez-Camacho, F Mollinedo PLoS One 4 (4), e5044, 2009 | 139 | 2009 |
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety ABS Maya, C Pérez-Melero, C Mateo, D Alonso, JL Fernández, C Gajate, ... Journal of medicinal chemistry 48 (2), 556-568, 2005 | 137 | 2005 |
In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts F Mollinedo, J de la Iglesia-Vicente, C Gajate, AEH de Mendoza, ... Clinical Cancer Research 16 (7), 2046-2054, 2010 | 124 | 2010 |