Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity K Hezaveh, RS Shinde, A Klötgen, MJ Halaby, S Lamorte, R Quevedo, ... Immunity 55 (2), 324-340. e8, 2022 | 254 | 2022 |
The aryl hydrocarbon receptor: connecting immunity to the microenvironment R Shinde, TL McGaha Trends in immunology 39 (12), 1005-1020, 2018 | 219 | 2018 |
Tolerance to apoptotic cells is regulated by indoleamine 2, 3-dioxygenase B Ravishankar, H Liu, R Shinde, P Chandler, B Baban, M Tanaka, ... Proceedings of the National Academy of Sciences 109 (10), 3909-3914, 2012 | 209 | 2012 |
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment MD Sharma, R Shinde, TL McGaha, L Huang, RB Holmgaard, ... Science advances 1 (10), e1500845, 2015 | 178 | 2015 |
Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1 C Roux, SM Jafari, R Shinde, G Duncan, DW Cescon, J Silvester, MF Chu, ... Proceedings of the National Academy of Sciences 116 (10), 4326-4335, 2019 | 160 | 2019 |
Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans R Shinde, K Hezaveh, MJ Halaby, A Kloetgen, A Chakravarthy, ... Nature immunology 19 (6), 571-582, 2018 | 158 | 2018 |
The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity B Ravishankar, H Liu, R Shinde, K Chaudhary, W Xiao, J Bradley, ... Proceedings of the National Academy of Sciences 112 (34), 10774-10779, 2015 | 152 | 2015 |
Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance B Ravishankar, R Shinde, H Liu, K Chaudhary, J Bradley, HP Lemos, ... Proceedings of the National Academy of Sciences 111 (11), 4215-4220, 2014 | 118 | 2014 |
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer G Mirji, A Worth, SA Bhat, M El Sayed, T Kannan, AR Goldman, HY Tang, ... Science immunology 7 (75), eabn0704, 2022 | 107 | 2022 |
Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy K Chaudhary, R Shinde, H Liu, JP Gnana-Prakasam, ... The Journal of Immunology 194 (12), 5713-5724, 2015 | 48 | 2015 |
Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, et al. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to … K Hezaveh, RS Shinde, A Klötgen, MJ Halaby, S Lamorte Immunity 55 (2), 324-340, 2022 | 40 | 2022 |
B cell–intrinsic IDO1 regulates humoral immunity to T cell–independent antigens R Shinde, M Shimoda, K Chaudhary, H Liu, E Mohamed, J Bradley, ... The Journal of Immunology 195 (5), 2374-2382, 2015 | 37 | 2015 |
Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model A Bhatta, R Sangani, R Kolhe, HA Toque, M Cain, A Wong, N Howie, ... Molecular and cellular endocrinology 422, 211-220, 2016 | 29 | 2016 |
Ciudad K Hezaveh, RS Shinde, A Klotgen, MJ Halaby, S Lamorte MT, Quevedo 1169, 324-340, 0 | 27 | |
Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function S Lamorte, R Shinde, TL McGaha Molecular aspects of medicine 78, 100942, 2021 | 25 | 2021 |
Selective memory to apoptotic cell–derived self-antigens with implications for systemic lupus erythematosus development A Duhlin, Y Chen, F Wermeling, SK Sedimbi, E Lindh, R Shinde, ... The Journal of Immunology 197 (7), 2618-2626, 2016 | 19 | 2016 |
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer KD Miller, S O’Connor, KA Pniewski, T Kannan, R Acosta, G Mirji, S Papp, ... Nature Cancer 4 (10), 1491-1507, 2023 | 17 | 2023 |
Alterations in bone metabolites with age in C57BL/6 mice model D Patel, TJ Lee, S Kumar, S Vyavahare, A Worth, WD Hill, M Hamrick, ... Biogerontology 23 (5), 629-640, 2022 | 5 | 2022 |
The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells M Sharma, R Shinde, T McGaha, L Huang, R Holmgaard, J Wolchok, ... Journal for immunotherapy of cancer, 2015 | 3 | 2015 |
Indoleamine 2, 3-dioxygenase inhibits B cell immune response to T independent antigens (IRM8P. 710) R Shinde, K Chaudhary, M Shimoda, G Pacholczyk, T McGaha The Journal of Immunology 192 (1_Supplement), 127.11-127.11, 2014 | 3 | 2014 |