Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration T Zorbaz, A Braïki, N Maraković, J Renou, E de La Mora, N Maček Hrvat, ... Chemistry–A European Journal 24 (38), 9675-9691, 2018 | 69 | 2018 |
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase … T Zorbaz, D Malinak, N Maraković, N Maček Hrvat, A Zandona, ... Journal of medicinal chemistry 61 (23), 10753-10766, 2018 | 66 | 2018 |
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes T Zorbaz, D Malinak, K Kuca, K Musilek, Z Kovarik Chemico-biological interactions 307, 16-20, 2019 | 38 | 2019 |
Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations M Katalinić, G Šinko, NM Hrvat, T Zorbaz, A Bosak, Z Kovarik Toxicology 406, 104-113, 2018 | 35 | 2018 |
Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning T Zorbaz, P Mišetić, N Probst, S Žunec, A Zandona, G Mendaš, ... ACS chemical neuroscience 11 (7), 1072-1084, 2020 | 34 | 2020 |
Reversal of Tabun Toxicity Enabled by a Triazole‐Annulated Oxime Library—Reactivators of Acetylcholinesterase Z Kovarik, J Kalisiak, NM Hrvat, M Katalinić, T Zorbaz, S Žunec, C Green, ... Chemistry–A European Journal 25 (16), 4100-4114, 2019 | 33 | 2019 |
The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation NM Hrvat, T Zorbaz, G Šinko, Z Kovarik Toxicology letters 293, 222-228, 2018 | 33 | 2018 |
New cinchona oximes evaluated as reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by organophosphorus compounds M Katalinić, A Zandona, A Ramić, T Zorbaz, I Primožič, Z Kovarik Molecules 22 (7), 1234, 2017 | 33 | 2017 |
Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease D Shulman, S Dubnov, T Zorbaz, N Madrer, I Paldor, DA Bennett, ... Alzheimer's & Dementia 19 (11), 5159-5172, 2023 | 20 | 2023 |
Cholinergic blockade of neuroinflammation: from tissue to RNA regulators T Zorbaz, N Madrer, H Soreq Neuronal signaling 6 (1), NS20210035, 2022 | 18 | 2022 |
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents T Zorbaz, D Malinak, T Hofmanova, N Maraković, S Žunec, NM Hrvat, ... European Journal of Medicinal Chemistry 238, 114377, 2022 | 16 | 2022 |
Neuropharmacology: Oxime antidotes for organophosphate pesticide and nerve agent poisoning T Zorbaz, Z Kovarik Periodicum biologorum, 35-54, 2020 | 16 | 2020 |
Stoichiometry of the heteromeric nicotinic receptors of the Renshaw cell BL d'Incamps, T Zorbaz, D Dingova, E Krejci, P Ascher Journal of Neuroscience 38 (21), 4943-4956, 2018 | 14 | 2018 |
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase Z Kovarik, NM Hrvat, J Kalisiak, M Katalinić, RK Sit, T Zorbaz, Z Radić, ... Toxicology and applied pharmacology 372, 40-46, 2019 | 12 | 2019 |
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons N Yayon, O Amsalem, T Zorbaz, O Yakov, S Dubnov, K Winek, A Dudai, ... The EMBO Journal 42 (1), e110565, 2023 | 8 | 2023 |
Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease M Gok, N Madrer, T Zorbaz, ER Bennett, D Greenberg, DA Bennett, ... Frontiers in Molecular Neuroscience 15, 941467, 2022 | 7 | 2022 |
Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells A Zandona, T Zorbaz, K Miš, S Pirkmajer, M Katalinić Archives of Industrial Hygiene and Toxicology 73 (4), 277-284, 2022 | 2 | 2022 |
Novi pristup analizi oksima dizajniranih za zaštitu središnjeg živčanog sustava pri trovanju organofosfornim spojevima T Zorbaz University of Zagreb. Faculty of Science. Department of Chemistry, 2018 | 2 | 2018 |
CHLORINATED PYRIDINIUM OXIMES ARE POTENT REACTIVATORS OF ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENTS. T Zorbaz, N Maraković, K Musilek, Z Kovarik Military Medical Science Letters/Vojenské zdravotnické Listy 87, 2018 | 1 | 2018 |
The effects of organophosphorus compounds and novel antidotes on human neuronal cells T Zorbaz, M Katalinić, I Ivan Pavičić, A Braïki, J Renou, PY Renard, L Jean, ... Nepoznat skup, 224-225, 2017 | 1 | 2017 |