| Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain L Zhao, D Cao, T Chen, Y Wang, Z Miao, Y Xu, W Chen, X Wang, Y Li, ... Journal of medicinal chemistry 56 (10), 3833-3851, 2013 | 146 | 2013 |
| Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors Z Xu, Z Liu, T Chen, TT Chen, Z Wang, G Tian, J Shi, X Wang, Y Lu, X Yan, ... Journal of medicinal chemistry 54 (15), 5607-5611, 2011 | 136 | 2011 |
| Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Y Xu, M Li, H Greenblatt, W Chen, A Paz, O Dym, Y Peleg, T Chen, ... Acta Crystallographica Section D: Biological Crystallography 68 (1), 13-25, 2012 | 108 | 2012 |
| Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel … N Ye, CH Chen, TT Chen, Z Song, JX He, XJ Huan, SS Song, Q Liu, ... Journal of medicinal chemistry 56 (7), 2885-2903, 2013 | 91 | 2013 |
| Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization L Zhao, Y Wang, D Cao, T Chen, Q Wang, Y Li, Y Xu, N Zhang, X Wang, ... Journal of medicinal chemistry 58 (3), 1281-1297, 2015 | 65 | 2015 |
| Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases Y Liu, W Zhang, L Li, LA Salvador, T Chen, W Chen, KM Felsenstein, ... Journal of medicinal chemistry 55 (23), 10749-10765, 2012 | 56 | 2012 |
| Thermodynamic and structural characterization of halogen bonding in protein–ligand interactions: a case study of PDE5 and its inhibitors J Ren, Y He, W Chen, T Chen, G Wang, Z Wang, Z Xu, X Luo, W Zhu, ... Journal of medicinal chemistry 57 (8), 3588-3593, 2014 | 49 | 2014 |
| Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors H Yuan, Q Liu, L Zhang, S Hu, T Chen, H Li, Y Chen, Y Xu, T Lu European journal of medicinal chemistry 143, 491-502, 2018 | 47 | 2018 |
| Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination H Cai, Q Liu, D Gao, T Wang, T Chen, G Yan, K Chen, Y Xu, H Wang, Y Li, ... European journal of medicinal chemistry 90, 241-250, 2015 | 43 | 2015 |
| Multisubstituted quinoxalines and pyrido [2, 3-d] pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors K Wu, J Ai, Q Liu, TT Chen, A Zhao, X Peng, Y Wang, Y Ji, Q Yao, Y Xu, ... Bioorganic & medicinal chemistry letters 22 (20), 6368-6372, 2012 | 42 | 2012 |
| Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: synthesis, SAR, and cellular activity Z Zhan, J Ai, Q Liu, Y Ji, T Chen, Y Xu, M Geng, W Duan ACS medicinal chemistry letters 5 (6), 673-678, 2014 | 37 | 2014 |
| Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors Y Zou, L Li, W Chen, T Chen, L Ma, X Wang, B Xiong, Y Xu, J Shen Molecules 18 (5), 5706-5722, 2013 | 36 | 2013 |
| Discovery of pyrazole as C-terminus of selective BACE1 inhibitors Y Zou, L Xu, W Chen, Y Zhu, T Chen, Y Fu, L Li, L Ma, B Xiong, X Wang, ... European journal of medicinal chemistry 68, 270-283, 2013 | 32 | 2013 |
| Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5 G Wang, Z Liu, T Chen, Z Wang, H Yang, M Zheng, J Ren, G Tian, X Yang, ... Journal of medicinal chemistry 55 (23), 10540-10550, 2012 | 32 | 2012 |
| Discovery of 6-(difluoro (6-(4-fluorophenyl)-[1, 2, 4] triazolo [4, 3-b][1, 2, 4] triazin-3-yl) methyl) quinoline as a highly potent and selective c-Met inhibitor Z Zhan, X Peng, Q Liu, F Chen, Y Ji, S Yao, Y Xi, Y Lin, T Chen, Y Xu, J Ai, ... European journal of medicinal chemistry 116, 239-251, 2016 | 30 | 2016 |
| NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds J Yu, T Chen, C Zhou, F Lian, X Tang, Y Wen, J Shen, Y Xu, B Xiong, ... Acta Pharmacologica Sinica 37 (7), 984-993, 2016 | 24 | 2016 |
| Microsecond molecular dynamics simulation of Aβ 42 and identification of a novel dual inhibitor of Aβ 42 aggregation and BACE1 activity Y Wang, L Li, T Chen, W Chen, Y Xu Acta Pharmacologica Sinica 34 (9), 1243-1250, 2013 | 20 | 2013 |
| The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch AL Photenhauer, RC Villafuerte-Vega, FM Cerqueira, KM Armbruster, ... Nature structural & molecular biology 31 (2), 255-265, 2024 | 9 | 2024 |
| The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors RD Murphy, T Chen, J Lin, R He, L Wu, CR Pearson, S Sharma, ... Journal of Biological Chemistry 298 (7), 2022 | 8 | 2022 |
| Structure-based discovery of PDEs inhibitors L Li, W Chen, T Chen, J Ren, Y Xu Current topics in medicinal chemistry 16 (9), 917-933, 2016 | 8 | 2016 |
