Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis M Strunz, LM Simon, M Ansari, JJ Kathiriya, I Angelidis, CH Mayr, ... Nature communications 11 (1), 3559, 2020 | 433 | 2020 |
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo M Lehmann, M Korfei, K Mutze, S Klee, W Skronska-Wasek, HN Alsafadi, ... European Respiratory Journal 50 (2), 2017 | 326 | 2017 |
Hyperoxia modulates TGF-β/BMP signaling in a mouse model of bronchopulmonary dysplasia MA Alejandre-Alcázar, G Kwapiszewska, I Reiss, OV Amarie, LM Marsh, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (2 …, 2007 | 303 | 2007 |
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices HN Alsafadi, CA Staab-Weijnitz, M Lehmann, M Lindner, B Peschel, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 312 (6 …, 2017 | 203 | 2017 |
Increased extracellular vesicles mediate WNT5A signaling in idiopathic pulmonary fibrosis A Martin-Medina, M Lehmann, O Burgy, S Hermann, HA Baarsma, ... American journal of respiratory and critical care medicine 198 (12), 1527-1538, 2018 | 159 | 2018 |
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis M Lehmann, L Buhl, HN Alsafadi, S Klee, S Hermann, K Mutze, C Ota, ... Respiratory research 19, 1-12, 2018 | 121 | 2018 |
Inhibition of LTβR signalling activates WNT-induced regeneration in lung TM Conlon, G John-Schuster, D Heide, D Pfister, M Lehmann, Y Hu, ... Nature 588 (7836), 151-156, 2020 | 108 | 2020 |
Reduced frizzled receptor 4 expression prevents WNT/β-catenin–driven alveolar lung repair in chronic obstructive pulmonary disease W Skronska-Wasek, K Mutze, HA Baarsma, KR Bracke, HN Alsafadi, ... American journal of respiratory and critical care medicine 196 (2), 172-185, 2017 | 100 | 2017 |
Poly (ADP-ribose) polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function S Erener, M Hesse, R Kostadinova, MO Hottiger Molecular endocrinology 26 (1), 79-86, 2012 | 90 | 2012 |
Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells M Lehmann, Q Hu, Y Hu, K Hafner, R Costa, A van den Berg, ... Cellular signalling 70, 109588, 2020 | 81 | 2020 |
S100a4 is secreted by alternatively activated alveolar macrophages and promotes activation of lung fibroblasts in pulmonary fibrosis W Zhang, S Ohno, B Steer, S Klee, CA Staab-Weijnitz, D Wagner, ... Frontiers in Immunology 9, 1216, 2018 | 75 | 2018 |
WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts S Klee, M Lehmann, DE Wagner, HA Baarsma, M Königshoff Scientific reports 6 (1), 20547, 2016 | 73 | 2016 |
WNT signaling in lung aging and disease M Lehmann, HA Baarsma, M Königshoff Annals of the American Thoracic Society 13 (Supplement 5), S411-S416, 2016 | 62 | 2016 |
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3 AEG Lindgren, T Karlberg, AG Thorsell, M Hesse, S Spjut, T Ekblad, ... ACS chemical biology 8 (8), 1698-1703, 2013 | 60 | 2013 |
ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high‐fat diet and impairs adipocyte function and differentiation S Erener, A Mirsaidi, M Hesse, AN Tiaden, H Ellingsgaard, R Kostadinova, ... The FASEB Journal 26 (6), 2631-2638, 2012 | 56 | 2012 |
ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange M Lehmann, E Pirinen, A Mirsaidi, FA Kunze, PJ Richards, J Auwerx, ... Nucleic acids research 43 (1), 129-142, 2015 | 54 | 2015 |
Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis C Ota, JP Ng-Blichfeldt, M Korfei, HN Alsafadi, M Lehmann, ... Scientific reports 8 (1), 12983, 2018 | 45 | 2018 |
Pulmonary CCR2+ CD4+ T cells are immune regulatory and attenuate lung fibrosis development K Milger, Y Yu, E Brudy, M Irmler, A Skapenko, M Mayinger, M Lehmann, ... Thorax 72 (11), 1007-1020, 2017 | 32 | 2017 |
Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration M Strunz, LM Simon, M Ansari, LF Mattner, I Angelidis, CH Mayr, ... BioRxiv, 705244, 2019 | 30 | 2019 |
Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis K Heinzelmann, M Lehmann, M Gerckens, N Noskovičová, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 315 (5 …, 2018 | 25 | 2018 |