Optimization of N-aryl-6-methoxy-1, 2, 3, 4-tetrahydroquinolines as tubulin polymerization inhibitors SB Wang, XF Wang, B Qin, E Ohkoshi, KY Hsieh, E Hamel, MT Cui, ... Bioorganic & medicinal chemistry 23 (17), 5740-5747, 2015 | 28 | 2015 |
Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines C Tan, Y Zhao, M Goto, KY Hsieh, X Yang, SL Morris-Natschke, L Liu, ... Bioorganic & medicinal chemistry letters 26 (5), 1495-1497, 2016 | 27 | 2016 |
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl) piperazinyl]-methyl)-camptothecin derivatives GX Zhu, PL Cheng, M Goto, N Zhang, SL Morris-Natschke, KY Hsieh, ... Bioorganic & medicinal chemistry letters 27 (8), 1750-1753, 2017 | 24 | 2017 |
Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells KY Hsieh, JY Tsai, YH Lin, FR Chang, HC Wang, CC Wu Scientific reports 11 (1), 4610, 2021 | 23 | 2021 |
Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues YH Wang, M Goto, LT Wang, KY Hsieh, SL Morris-Natschke, GH Tang, ... Bioorganic & medicinal chemistry letters 24 (20), 4818-4821, 2014 | 23 | 2014 |
YC-1 prevents tumor-associated tissue factor expression and procoagulant activity in hypoxic conditions by inhibiting p38/NF-κB signaling pathway KY Hsieh, CK Wei, CC Wu International journal of molecular sciences 20 (2), 244, 2019 | 15 | 2019 |
Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties CJ Yang, ZL Song, M Goto, YQ Liu, KY Hsieh, SL Morris-Natschke, ... Bioorganic & medicinal chemistry letters 27 (17), 3959-3962, 2017 | 13 | 2017 |
Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid J Li, LC Chang, KY Hsieh, PL Hsu, SJ Capuzzi, YC Zhang, KP Li, ... Bioorganic & Medicinal Chemistry 27 (13), 2871-2882, 2019 | 12 | 2019 |
Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex S Li, KY Hsieh, CI Kuo, SC Su, KF Huang, K Zhang, CI Chang Science Advances 7 (46), eabj9537, 2021 | 11 | 2021 |
Complete three-dimensional structures of the Lon protease translocating a protein substrate S Li, KY Hsieh, CI Kuo, SH Lee, GD Pintilie, K Zhang, CI Chang Science advances 7 (42), eabj7835, 2021 | 11 | 2021 |
Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease S Li, KY Hsieh, SC Su, GD Pintilie, K Zhang, CI Chang Journal of Biological Chemistry 297 (4), 2021 | 11 | 2021 |
Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum WH Yuan, M Goto, KY Hsieh, B Yuan, Y Zhao, SL Morris-Natschke, ... Journal of Asian natural products research 17 (12), 1239-1244, 2015 | 11 | 2015 |
Design, synthesis and structure–activity relationships of (±)-isochaihulactone derivatives Y Zhao, PY Liu, KY Hsieh, PL Hsu, M Goto, SL Morris-Natschke, HJ Harn, ... Medchemcomm 8 (11), 2040-2049, 2017 | 5 | 2017 |
A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine S Li, KY Hsieh, CI Kuo, TC Lin, SH Lee, YR Chen, CH Wang, MR Ho, ... Nature Communications 14 (1), 7340, 2023 | 2 | 2023 |
Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis M Li, H Liu, KY Hsieh, S Zhang, Y Gao, Q Gong, K Zhang, CI Chang, S Li Fundamental Research, 2024 | | 2024 |
Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan HJ Wang, VM Hernández-Rocamora, CI Kuo, KY Hsieh, SH Lee, MR Ho, ... Mbio 14 (5), e01379-23, 2023 | | 2023 |
Structural Basis for the Peptidoglycan-Editing Activity of YfiH MS Lee, KY Hsieh, CI Kuo, SH Lee, S Garde, M Reddy, CI Chang Mbio 13 (1), e03646-21, 2022 | | 2022 |