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Kan-Yen Hsieh
Kan-Yen Hsieh
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University
在 kmu.edu.tw 的电子邮件经过验证
标题
引用次数
引用次数
年份
Optimization of N-aryl-6-methoxy-1, 2, 3, 4-tetrahydroquinolines as tubulin polymerization inhibitors
SB Wang, XF Wang, B Qin, E Ohkoshi, KY Hsieh, E Hamel, MT Cui, ...
Bioorganic & medicinal chemistry 23 (17), 5740-5747, 2015
282015
Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines
C Tan, Y Zhao, M Goto, KY Hsieh, X Yang, SL Morris-Natschke, L Liu, ...
Bioorganic & medicinal chemistry letters 26 (5), 1495-1497, 2016
272016
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl) piperazinyl]-methyl)-camptothecin derivatives
GX Zhu, PL Cheng, M Goto, N Zhang, SL Morris-Natschke, KY Hsieh, ...
Bioorganic & medicinal chemistry letters 27 (8), 1750-1753, 2017
242017
Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells
KY Hsieh, JY Tsai, YH Lin, FR Chang, HC Wang, CC Wu
Scientific reports 11 (1), 4610, 2021
232021
Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues
YH Wang, M Goto, LT Wang, KY Hsieh, SL Morris-Natschke, GH Tang, ...
Bioorganic & medicinal chemistry letters 24 (20), 4818-4821, 2014
232014
YC-1 prevents tumor-associated tissue factor expression and procoagulant activity in hypoxic conditions by inhibiting p38/NF-κB signaling pathway
KY Hsieh, CK Wei, CC Wu
International journal of molecular sciences 20 (2), 244, 2019
152019
Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties
CJ Yang, ZL Song, M Goto, YQ Liu, KY Hsieh, SL Morris-Natschke, ...
Bioorganic & medicinal chemistry letters 27 (17), 3959-3962, 2017
132017
Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid
J Li, LC Chang, KY Hsieh, PL Hsu, SJ Capuzzi, YC Zhang, KP Li, ...
Bioorganic & Medicinal Chemistry 27 (13), 2871-2882, 2019
122019
Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex
S Li, KY Hsieh, CI Kuo, SC Su, KF Huang, K Zhang, CI Chang
Science Advances 7 (46), eabj9537, 2021
112021
Complete three-dimensional structures of the Lon protease translocating a protein substrate
S Li, KY Hsieh, CI Kuo, SH Lee, GD Pintilie, K Zhang, CI Chang
Science advances 7 (42), eabj7835, 2021
112021
Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease
S Li, KY Hsieh, SC Su, GD Pintilie, K Zhang, CI Chang
Journal of Biological Chemistry 297 (4), 2021
112021
Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum
WH Yuan, M Goto, KY Hsieh, B Yuan, Y Zhao, SL Morris-Natschke, ...
Journal of Asian natural products research 17 (12), 1239-1244, 2015
112015
Design, synthesis and structure–activity relationships of (±)-isochaihulactone derivatives
Y Zhao, PY Liu, KY Hsieh, PL Hsu, M Goto, SL Morris-Natschke, HJ Harn, ...
Medchemcomm 8 (11), 2040-2049, 2017
52017
A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine
S Li, KY Hsieh, CI Kuo, TC Lin, SH Lee, YR Chen, CH Wang, MR Ho, ...
Nature Communications 14 (1), 7340, 2023
22023
Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
M Li, H Liu, KY Hsieh, S Zhang, Y Gao, Q Gong, K Zhang, CI Chang, S Li
Fundamental Research, 2024
2024
Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan
HJ Wang, VM Hernández-Rocamora, CI Kuo, KY Hsieh, SH Lee, MR Ho, ...
Mbio 14 (5), e01379-23, 2023
2023
Structural Basis for the Peptidoglycan-Editing Activity of YfiH
MS Lee, KY Hsieh, CI Kuo, SH Lee, S Garde, M Reddy, CI Chang
Mbio 13 (1), e03646-21, 2022
2022
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