| Characteristic physical properties and structural fragments of marketed oral drugs M Vieth, MG Siegel, RE Higgs, IA Watson, DH Robertson, KA Savin, ... Journal of medicinal chemistry 47 (1), 224-232, 2004 | 435 | 2004 |
| Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries SW Kaldor, MG Siegel, JE Fritz, BA Dressman, PJ Hahn Tetrahedron letters 37 (40), 7193-7196, 1996 | 318 | 1996 |
| Rapid purification of small molecule libraries by ion exchange chromatography MG Siegel, PJ Hahn, BA Dressman, JE Fritz, JR Grunwell, SW Kaldor Tetrahedron letters 38 (19), 3357-3360, 1997 | 181 | 1997 |
| Combinatorial chemistry using polymer-supported reagents SW Kaldor, MG Siegel Current Opinion in Chemical Biology 1 (1), 101-106, 1997 | 144 | 1997 |
| Drugs in other drugs: a new look at drugs as fragments MG Siegel, M Vieth Drug discovery today 12 (1-2), 71-79, 2007 | 89 | 2007 |
| The application of high-throughput synthesis and purification to the preparation of ethanolamines AJ Shuker, MG Siegel, DP Matthews, LO Weigel Tetrahedron letters 38 (35), 6149-6152, 1997 | 65 | 1997 |
| A highly stereoselective approach to the synthesis of the manzamine alkaloids via the intramolecular vinylogous amide photocycloaddition JD Winkler, MG Siegel, JE Stelmach Tetrahedron letters 34 (41), 6509-6512, 1993 | 65 | 1993 |
| Diphenylether amide derivatives as opioid receptor antagonists CH Mitch, SJ Quimby, MG Siegel US Patent 7,378,448, 2008 | 63 | 2008 |
| Diaryl ethers as opioid receptor antagonist MJ Blanco-Pillado, MG De La Torre, ND Buezo, WG Holloway, JE Matt, ... US Patent 7,381,719, 2008 | 46 | 2008 |
| Prioritization of molecular targets for antimalarial drug discovery B Forte, S Ottilie, A Plater, B Campo, KJ Dechering, FJ Gamo, ... ACS infectious diseases 7 (10), 2764-2776, 2021 | 43 | 2021 |
| The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents MG Siegel, AJ Shuker, CA Droste, PJ Hahn, CD Jesudason, ... Molecular diversity 3, 113-116, 1997 | 34 | 1997 |
| Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines MG Organ, D Mayhew, JT Cooper, CE Dixon, DJ Lavorato, SW Kaldor, ... Journal of Combinatorial Chemistry 3 (1), 64-67, 2001 | 23 | 2001 |
| Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists MG Siegel, MO Chaney, RF Bruns, MP Clay, DA Schober, ... Tetrahedron 55 (39), 11619-11639, 1999 | 23 | 1999 |
| An Approach to the Synthesis of the Manzamine Alkaloids Via the Vinylogous Amide PHotocycloAddition/Retro‐Mannich Fragmentation/Mannich Closure … JD Winkler, JE Stelmach, MG Siegel, N Haddad, J Axten, WP Dailey III Israel journal of chemistry 37 (1), 47-67, 1997 | 22 | 1997 |
| Ten-membered ring templates for stereoselective radical cyclizations JD Winkler, V Sridar, MG Siegel Tetrahedron letters 30 (37), 4943-4946, 1989 | 19 | 1989 |
| Generation of penems, carbapenems and aza analogs of cephems by the addition of heterocycles and other building blocks to azetinones HH Wasserman, M Xia, AJ Carr, WT Han, MG Siegel Tetrahedron 56 (31), 5621-5629, 2000 | 18 | 2000 |
| Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2 K Takeuchi, WG Holloway, CH Mitch, SJ Quimby, JH McKinzie, TM Suter, ... Bioorganic & medicinal chemistry letters 17 (24), 6841-6846, 2007 | 17 | 2007 |
| SAR and biological evaluation of novel trans-3, 4-dimethyl-4-arylpiperidine derivatives as opioid antagonists N Díaz, M Benvenga, P Emmerson, R Favors, M Mangold, J McKinzie, ... Bioorganic & medicinal chemistry letters 15 (17), 3844-3848, 2005 | 16 | 2005 |
| β3 adrenergic agonists B Evers, CD Jesudason, RE Karanjawala, DM Remick, DJ Sall, ... US Patent 6,730,792, 2004 | 16 | 2004 |
| Synthesis of chlorinated arenes and hetarenes by one-pot cyclizations of 1, 3-bis-silyl enol ethers Z Hassan, P Langer Synlett 30 (06), 665-673, 2019 | 12 | 2019 |
